Exendin-4 partly ameliorates - hyperglycemia-mediated tissue damage in lungs of streptozotocin-induced diabetic mice

Öztay, Füsun; Sancar-Bas, Serap; Gezginci‐Oktayoglu, Selda; Ercin, Merve; Bolkent, Şehnaz

doi:10.1016/j.peptides.2017.12.007

Cited by 19 publications

(12 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In cells receiving apoptosis signal, caspase-3 activate CAD (caspase-activated deoxyribonuclease), and this enzyme rapidly breaks the DNA into nucleosomal fragments. The apoptosis pathway is regulated by caspases, and caspase-3 activation is induced by high glucose in the lungs of diabetic rats 19 . In our study, caspase-3 expression was relatively low in the control rats.…”

Section: Discussionmentioning

confidence: 99%

Streptozotosin kaynaklı diyabette akciğer hasarı: deneysel bir çalışma

Bolat

ÜLGER

Baran

et al. 2022

Cukurova Medical Journal

View full text Add to dashboard Cite

The aim of the study explores the impact and potential mechanisms on the STZ (Streptozotocin)induced diabetes model histopathologically and immunohistochemically on diabetic lung fibrosis. Materials and Methods: In this study, 14 adult female Wistar albino rats were divided into groups of seven random animals: the control and STZ induced diabetic groups. In the study, a blood glucose level above 200 mg/dl was accepted as diabetes. Nine days after the experiment, the rats were sacrificed under anesthesia and lung samples were taken from each. The histopathological appearance of the samples was evaluated and histopathologic damage score was performed. Apoptosis and inflammation in tissues were evaluated with caspase-3 and IL-1β immunohistochemically. Results: In the histopathological examination, the STZ group had a higher histopathologic damage score than the control group, and there were findings such as vascular congestion, thickened alveolar wall, and inflammatory cell infiltration. In the caspase-3 immunohistochemistry, staining of the lung tissues of the STZ group was higher than the control group. This difference was also significant in terms of IL-1β immunoreactivity intensity. Conclusion:This study determined that lung complications and damage due to diabetes-induced by STZ occurred. Amaç: Bu çalışmanın amacı, diyabetik akciğer fibrozisi üzerine histopatolojik ve immünohistokimyasal olarak STZ (Streptozotosin) kaynaklı diyabet modeli üzerindeki etki ve potansiyel mekanizmaları araştırmaktır. Gereç ve Yöntem: Bu çalışmada, 14 yetişkin dişi Wistar albino sıçan, 7 rastgele hayvandan oluşan gruplara ayrıldı: kontrol ve STZ ile indüklenen diyabet grupları. Çalışmada kan şekerinin 200 mg/dl'nin üzerinde olması diyabet olarak kabul edildi. Deneyden dokuz gün sonra sıçanlar anestezi altında sakrifiye edildi ve her birinin akciğer örnekleri alındı. Örneklerin histopatolojik görünümleri değerlendirildi ve histopatolojik hasar skoru yapıldı. Dokulardaki apoptoz ve inflamasyon, immünohistokimyasal olarak kaspaz-3 ve IL-1β ile değerlendirildi. Bulgular: Histopatolojik incelemede STZ grubunun histopatolojik hasar skoru kontrol grubuna göre daha yüksekti ve damar tıkanıklığı, alveol duvarında kalınlaşma, inflamatuar hücre infiltrasyonu gibi bulgular vardı. Kaspaz-3 immünohistokimyasında, STZ grubunda akciğer dokularının boyanması kontrol grubuna göre daha yüksekti. Bu fark, IL-1β immünreaktivite yoğunluğu açısından da anlamlıydı. Sonuç: Bu çalışmada STZ'ye bağlı olarak pulmoner komplikasyonların ve diyabete bağlı hasarın oluştuğu belirlendi.

show abstract

Section: Discussionmentioning

confidence: 99%

Streptozotosin kaynaklı diyabette akciğer hasarı: deneysel bir çalışma

Bolat

ÜLGER

Baran

et al. 2022

Cukurova Medical Journal

View full text Add to dashboard Cite

show abstract

“…However, there is one study reporting beneficial modulations of markers of immunity with liraglutide therapy in T2DM patients with stable COPD [69]. In diabetic mice, exenatide treatment improved pulmonary oedema, oxidative stress, and apoptosis, but disrupted insulin signalling and increased interstitial collagen accumulation in the lungs [70].…”

Section: Effects Of Antidiabetic Drugs On Copdmentioning

confidence: 99%

Diabetes Mellitus and Chronic Obstructive Pulmonary Disease: An Overview

Katsiki

Steiropoulos

Παπάνας

et al. 2019

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is a common disease with an increasing prevalence, characterised by persistent respiratory symptoms and airflow limitation. Apart from cigarette smoking, certain occupational and environmental exposures, low socioeconomic status and genetic factors may contribute to the pathogenesis of COPD. Comorbidities, e. g. diabetes mellitus (DM), can negatively affect quality of life, COPD outcomes and cardiovascular risk. The present narrative review considers the potential links between COPD and DM, such as systemic inflammation, oxidative stress, hypoxaemia and hyperglycaemia. The effects of antidiabetic drugs on lung function and COPD outcomes, as well as the possibility of common therapeutic modalities are also briefly considered. Further research is needed in this field to elucidate these relationships as well as their potential clinical implications in daily practice.

show abstract

“…Therefore, GLP-1 RAs downregulate inflammatory mediators and the autoimmune response that causes the destruction of pancreatic islets cells. The use of GLP-1 RAs reduces the macrophages that are recruited to the adipose tissue and reduces the production of TNF-alpha, MCP-1, and IL-6 in the surrounding adipose tissue [ 4 ]. This is done via the inhibition of NF-Kb activation and phosphorylation of ERK1/2 and c-Jun N-terminal kinases.…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Asthma: A Literature Review

Kanwar¹,

Sunku²,

Alruwaili³

et al. 2022

Cureus

View full text Add to dashboard Cite

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are approved to treat type 2 diabetes mellitus. The anti-inflammatory and anti-obesity properties of GLP-1 RAs as well as their moderating effects on multiple pathobiological pathways in asthma pathogenesis may decrease asthma exacerbations, improve quality of life, and decrease premature death among patients with asthma and co-morbid diabetes or obesity.The aim of this literature review is to discuss evidence from basic science, human studies, and clinical trials to support the preferential use of GLP-1 RAs in asthma patients with co-occurring diabetes and obesity.The preliminary data on the effect of GLP-1 RAs on asthma in patients with diabetes are promising and merit further trials and research studies.

show abstract

Exendin-4 partly ameliorates - hyperglycemia-mediated tissue damage in lungs of streptozotocin-induced diabetic mice

Cited by 19 publications

References 43 publications

Streptozotosin kaynaklı diyabette akciğer hasarı: deneysel bir çalışma

Streptozotosin kaynaklı diyabette akciğer hasarı: deneysel bir çalışma

Diabetes Mellitus and Chronic Obstructive Pulmonary Disease: An Overview

Beneficial Effects of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Asthma: A Literature Review

Contact Info

Product

Resources

About