Exercise and Uric Acid: Implication in Cardiovascular Disease

Francis, Kennon; Hamrick, Maynard E.

doi:10.2519/jospt.1984.6.1.34

Cited by 16 publications

(8 citation statements)

References 24 publications

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“…48 However, although acute exercise lasting between one-half and 3 h appears to elevate serum uric acid in proportion to the intensity of exercise, chronic exercise appears to lower serum uric acid levels. 49 In our study, participating in leisure-time physical activity (exercise and sports) was not associated with hyperuricemia, but we found a dose-response association between physical activity related to daily living and hyperuricemia. Most middleaged and elderly Chinese men in Shanghai participate in a high level of nonexercise-related physical activity, but have relatively low participation in leisure-time physical activity.…”

Section: Resultscontrasting

confidence: 50%

Prevalence and Determinants of Hyperuricemia in Middle-Aged, Urban Chinese Men

Villegas

Xiang

Cai

et al. 2010

Metabolic Syndrome and Related Disorders

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Background: Hyperuricemia is associated with metabolic syndrome and has emerged as a marker for both type 2 diabetes and cardiovascular disease. We estimated the prevalence and lifestyle risk factors of hyperuricemia in middle-aged, urban Chinese men. Methods: The study included 3,978 urban Chinese men 40-74 years of age from a population-based cohort study, the Shanghai Men's Health Study, who were free of type 2 diabetes at baseline and had provided fasting blood samples. Uric acid concentrations were measured by the uricase method. Hyperuricemia was defi ned as >7.0 mg/dL. Anthropometric measurements and information on lifestyle factors and disease history were collected by in-person interviews. Results: One quarter of the study subjects had hyperuricemia. Participants with metabolic syndrome had a higher prevalence of hyperuricemia. Body mass index (BMI), waist-to-hip ratio (WHR), waist circumference, and weight gain (since age 20) were positively associated with the prevalence of hyperuricemia. Physical activity was inversely related to the prevalence of hyperuricemia. The odds ratios for hyperuricemia for quintiles of nonoccupational physical activity were 1.00, 0.80, 0.73, 0.75, and 0.57 ( P trend <0.001). Participants with hyperuricemia were less likely to be current smokers, but were more likely to drink alcohol regularly. Beer consumption was associated with higher risk of hyperuricemia compared with consumption of wine or liquor. Conclusions: In this representative sample of middle-aged, urban Chinese men, hyperuricemia is highly prevalent. Obesity, weight gain in adulthood, and alcohol intake were associated with a higher prevalence of hyperuricemia, whereas daily physical activity and smoking were inversely related to the prevalence of hyperuricemia.

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Section: Resultscontrasting

confidence: 50%

Prevalence and Determinants of Hyperuricemia in Middle-Aged, Urban Chinese Men

Villegas

Xiang

Cai

et al. 2010

Metabolic Syndrome and Related Disorders

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“…All these biomarkers were risk factors for CMD (Supplementary Table S7 ), and they showed a positive association with participating in regular exercise, although albumin and ALP were not significant (Supplementary Table S5 ). Elevating these biomarkers after exercise has been observed in previous studies and is probably due to adverse effects from exercise, such as damage to muscle cells or hepatic or renal stress 15 , 34 – 39 . However, the magnitude of the indirect effects via these mediators and their proportion were much less than those of the other mediators, which showed beneficial mediated effects.…”

Section: Discussionsupporting

confidence: 58%

Network of biomarkers and their mediation effects on the associations between regular exercise and the incidence of cardiovascular & metabolic diseases

Park

Choi

Kim

et al. 2021

Sci Rep

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This study aimed to understand the biological process related to the prevention of cardiovascular & metabolic diseases (CMD), including diabetes, hypertension, and dyslipidemia via regular exercise. This study included 17,053 subjects aged 40–69 years in the Health Examinees Study from 2004 to 2012. Participation in regular exercise was investigated by questionnaires. Data on 42 biomarkers were collected from anthropometric measures and laboratory tests. We examined the associations between regular exercise and biomarkers using general linear models, between biomarkers and the risk of CMD using cox proportional hazard models, and the mediation effect of biomarkers using mediation analyses. Biomarker networks were constructed based on the significant differential correlations (p < 0.05) between the exercise and non-exercise groups in men and women, respectively. We observed significant mediators in 14 and 16 of the biomarkers in men and women, respectively. Triglyceride level was a noteworthy mediator in decreasing the risk of CMD with exercise, explaining 23.79% in men and 58.20% in women. The biomarker network showed comprehensive relationships and associations among exercise, biomarkers, and CMD. Body composition-related biomarkers were likely to play major roles in men, while obesity-related biomarkers seemed to be key factors in women.

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“…Regular long-term aerobic training reduced the level of SUA. Francis and Hamrick 6 have confirmed that the low-to-medium aerobic training program of 8 weeks decreased the level of SUA. Furthermore, Lamina and Okoye concluded that moderate-intensity aerobic exercise showed a decrease in the level of SUA.…”

Section: Analysing the Results And Discussionmentioning

confidence: 87%

Dr Effect of a Healthy-psychological Course in Levels of Serum Uric Acid and the Psychology of Pessimism and Depression in the Elderly

Jallu

Abdulridha

Hasan

2021

JPTCP

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The aim of this research is to prepare a healthy psychological course and study its impact on the levels of serum uric acid (SUA) and pessimism and depression. The research sample was limited to teaching staff of the Iraqi State Universities in Baghdad, who were retired at 63-65 years of age. Data were collected by independent group experimental approach via pre-and posttest measurements. The study sample consisted of 21 people with cases of pessimism and depression. The sample was randomly chosen based on their consent to do pre-and posttests and to be subjected to healthy psychological approach. After collecting the data obtained from the samples and processing them statistically, the results showed that the healthy psychological course had a positive effect on the levels of SUA, pessimism, and depression of the research sample.

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Exercise and Uric Acid: Implication in Cardiovascular Disease

Cited by 16 publications

References 24 publications

Prevalence and Determinants of Hyperuricemia in Middle-Aged, Urban Chinese Men

Prevalence and Determinants of Hyperuricemia in Middle-Aged, Urban Chinese Men

Network of biomarkers and their mediation effects on the associations between regular exercise and the incidence of cardiovascular & metabolic diseases

Dr Effect of a Healthy-psychological Course in Levels of Serum Uric Acid and the Psychology of Pessimism and Depression in the Elderly

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