Exercise as an Intervention for Frailty

Liu, Christine K.; Fielding, Roger A.

doi:10.1016/j.cger.2010.08.001

Cited by 176 publications

(111 citation statements)

References 51 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…Although we did not find differences in sirtuin 1 expression in the skeletal muscle that correlate with the gene expression increase detected in fP8WR mice, we did find a significant increase in PGC-1α and in the sirtuin 1 activator AMPK in these mice. Interestingly, the activation of the sirtuin 1-AMPK-PGC-1α pathway is involved in mitochondrial biogenesis (Chen et al 2008;Liu et al 2012) and has been previously proposed as a possible target of molecular changes induced by exercise (Liu and Fielding 2011;Canto and Auwerx 2009). Indeed, evidence suggests that moderate levels of regular physical activity increase a larger number of mitochondrial biogenesis-related gene expression in aged subjects, though to a lesser extent than in younger individuals (Bori et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Long-term wheel running changes on sensorimotor activity and skeletal muscle in male and female mice of accelerated senescence

Sanchez‐Roige

Lalanza

Álvarez-López

et al. 2014

AGE

View full text Add to dashboard Cite

The senescence-accelerated mouse prone 8 (SAMP8) is considered a useful non-transgenic model for studying aspects of aging. Using SAM resistant 1 (SAMR1) as controls, the long-term effects of wheel running on skeletal muscle adaptations and behavioral traits were evaluated in senescent (P8) and resistant (R1) male and female mice. Longterm wheel running (WR) led to increases in locomotor activity, benefits in sensorimotor function, and changes in body weight in a gender-dependent manner. WR increased body weight and baseline levels of locomotor activity in female mice and improved balance and strength in male mice, compared to sedentary-control mice. WR resulted in key metabolic adaptations in skeletal muscle, associated with an increased activity of the sirtuin 1-AMP-activated protein kinase (AMPK)-PGC-1 alpha axis and changes in vascular endothelial growth factor A (Vegfa), glucose transporter type 4 (Glut4), and Cluster of Differentiation 36 (Cd36) gene expression. Overall, our data indicate that activity, balance, and strength decrease with age and that long-term WR may significantly improve the motor function in a mouse model of senescence in a gender-dependent manner.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-term wheel running changes on sensorimotor activity and skeletal muscle in male and female mice of accelerated senescence

Sanchez‐Roige

Lalanza

Álvarez-López

et al. 2014

AGE

View full text Add to dashboard Cite

show abstract

“…Less than 2 times would likely not improve fitness, while greater than 3 times per week may cause some individuals to become over trained and lose interest. Clinicians should aim to progress exercise frequency toward the upper end of the recommended range to facilitate positive behaviour modification (longer term exercise adherence) and promote exercise progression (Liu and Fielding 2011).…”

Section: Frequencymentioning

confidence: 99%

Exercise prescription to reverse frailty

Bray

Smart

Jakobi

et al. 2016

Appl. Physiol. Nutr. Metab.

152

103

View full text Add to dashboard Cite

Abstract:Frailty is a clinical geriatric syndrome caused by physiological deficits across multiple systems. These deficits make it challenging to sustain homeostasis required for the demands of everyday life. Exercise is likely the best therapy to reverse frailty status. Literature to date suggests that pre-frail older adults, those with 1-2 deficits on the Cardiovascular Health Study-Frailty Phenotype (CHS-frailty phenotype), should exercise 2-3 times a week, for 45-60 min. Aerobic, resistance, flexibility, and balance training components should be incorporated but resistance and balance activities should be emphasized. On the other hand, frail (CHS-frailty phenotype ≥ 3 physical deficits) older adults should exercise 3 times per week, for 30-45 min for each session with an emphasis on aerobic training. During aerobic, balance, and flexibility training, both frail and pre-frail older adults should work at an intensity equivalent to a rating of perceived exertion of 3-4 ("somewhat hard") on the Borg CR10 scale. Resistance-training intensity should be based on a percentage of 1-repetition estimated maximum (1RM). Program onset should occur at 55% of 1RM (endurance) and progress to higher intensities of 80% of 1RM (strength) to maximize functional gains. Exercise is the medicine to reverse or mitigate frailty, preserve quality of life, and restore independent functioning in older adults at risk of frailty.Key words: aging, frailty, exercise prescription, exercise training, resistance exercise, exercise recommendations.Résumé : La fragilité est un syndrome gériatrique clinique qui résulte de déficits physiologiques de plusieurs systèmes. Ces déficits constituent un défi pour le maintien de l'homéostasie exigée dans la vie de tous les jours. L'exercice physique est vraisemblablement le meilleur traitement pour contrer l'état de la fragilité. D'après la documentation existante, les personnes âgées au seuil de la fragilité, soient celles présentant 1 ou 2 déficits selon le phénotype de fragilité dans l'Étude sur la santé cardiovasculaire (« CHS »-phénotype de fragilité), devraient effectuer des exercices 2 à 3 fois par semaine à raison de 45 à 60 minutes par séance. Les séances devraient comprendre des exercices aérobies, contre résistance, de flexibilité et d'équilibre, mais devraient surtout mettre l'accent sur la résistance et la flexibilité. D'autre part, les personnes âgées présentant 3 déficits ou plus selon le CHS-phénotype de fragilité devraient effectuer des exercices physiques 3 fois par semaine à raison de 30 à 45 minutes par séance et mettre l'accent sur l'entraînement aérobie. Au cours des séances d'entraînement aérobie, d'équilibre et de flexibilité, les personnes âgées frêles et au seuil de fragilité devraient effectuer des efforts de niveau 3-4 (« assez difficile ») sur l'échelle CR10 de Borg. On devrait effectuer les exercices contre résistance à un pourcentage du maximum estimé (« 1RM »). Les programmes devraient démarrer à 55 % 1RM (endurance) et progresser vers des intensités plus élevées, soit 80 ...

show abstract

“…The importance of participation for the elderly population in an aerobic type of exercise program is enhanced by the need of confronting the decline of aerobic capacity that is observed with aging 27,28 . That state will influence the performance of daily activities of living and consequently the independency of the individual.…”

Section: Effects Of Aerobic/resistance Exercises On Frail and Sarcopementioning

confidence: 99%

“…According to studies that took place in the recent years, resistance type of exercise is an important appliance in the improvement/increase of muscle mass and therefore the muscle strength in both younger and older adults 27,28 . It is commonly accepted that the strength presented by a muscle structure is facing deterioration as a natural aftereffect of the ageing process 27,38,39 . Being well-documented, the associated decrease of muscle strength is up to 12-15% per decade after the age of 50 for both genders and is taking its peak after the age of 70 years old 38,39 .…”

Section: Effects Of Resistance Exercises On Frail and Sarcopenic Patimentioning

confidence: 99%

“…Encouraging the patient to attend an aerobic/endurance type physical activity program will improve the aerobic capacity and thus counter the associated decline being the result of aging and physical inactivity 27,35 . Studies that was performed in a large group of elders for a period of 9 months and included strength training and walking exercises, improved individual's endurance, resistance against fatigue and muscle's oxidative capacity.…”

mentioning

confidence: 99%

See 1 more Smart Citation