Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice

Téglás, Tímea; Ábrahám, Dóra; Jókai, Mátyás; Kondo, Shu; Mohammadi, Rezieh; Fehér, János; Szabó, Dóra; Wilhelm, Márta; Radák, Zsolt

doi:10.1007/s10522-020-09895-7

Cited by 28 publications

(12 citation statements)

References 63 publications

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“…It has been reported that probiotic interventions can effectively prevent cognitive impairment and improve cognition in both humans and other animals [24,28]. Additionally, several studies have described the beneficial effects of exercise and probiotic treatment on cognition in mouse models of AD [29][30][31]. However, these studies have mainly evaluated the effects of such interventions on specific memory domains.…”

Section: Discussionmentioning

confidence: 99%

Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

Zhu¹,

Guo²,

Zhao³

et al. 2024

Food Science and Human Wellness

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The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease (AD), a neurodegenerative disease characterised by behavioural and cognitive impairment. However, most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive improvements. Here, we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment (EE) training. In this study, we found that compared with EE or B. breve treatment alone, B. breve intervention combined with EE amplified its neuroprotective effects on AD mice, as reflected by improved cognition, inhibited neuroinflammation and enhanced synaptic function. Moreover, using microbiome and metabolome profiling, we found that the combination of B. breve and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite changes. Finally, by integrating behavioural and neurological data with metabolomic profiles, we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain interactions. Collectively, combined B. breve intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut microbiome. Our findings provide a promising multidomain intervention strategy, with a combination of dietary microbiome-based and lifestyle-targeted interventions, to promote brain function and delay the progression of AD.

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Section: Discussionmentioning

confidence: 99%

Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

Zhu¹,

Guo²,

Zhao³

et al. 2024

Food Science and Human Wellness

View full text Add to dashboard Cite

show abstract

“…On the contrary, Abraham and co-workers (2019) [ 90 ] and Teglas and co-workers (2020) [ 91 ] expose AD-injected mice with probiotic supplementation together with interval treadmill running. Interestingly, they discover that these combination resulted in the increase of Lactobacillus reuteri in gut, NRF-2 in the liver, and 8-oxodG level in hippocampus in addition to other outcome as witnessed by other researchers [ 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

Probiotics for Alzheimer’s Disease: A Systematic Review

et al. 2021

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Alzheimer’s disease (AD) is the most common form of neurodegenerative disorders affecting mostly the elderly. It is characterized by the presence of Aβ and neurofibrillary tangles (NFT), resulting in cognitive and memory impairment. Research shows that alteration in gut microbial diversity and defects in gut brain axis are linked to AD. Probiotics are known to be one of the best preventative measures against cognitive decline in AD. Numerous in vivo trials and recent clinical trials have proven the effectiveness of selected bacterial strains in slowing down the progression of AD. It is proven that probiotics modulate the inflammatory process, counteract with oxidative stress, and modify gut microbiota. Thus, this review summarizes the current evidence, diversity of bacterial strains, defects of gut brain axis in AD, harmful bacterial for AD, and the mechanism of action of probiotics in preventing AD. A literature search on selected databases such as PubMed, Semantic Scholar, Nature, and Springer link have identified potentially relevant articles to this topic. However, upon consideration of inclusion criteria and the limitation of publication year, only 22 articles have been selected to be further reviewed. The search query includes few sets of keywords as follows. (1) Probiotics OR gut microbiome OR microbes AND (2) Alzheimer OR cognitive OR aging OR dementia AND (3) clinical trial OR in vivo OR animal study. The results evidenced in this study help to clearly illustrate the relationship between probiotic supplementation and AD. Thus, this systematic review will help identify novel therapeutic strategies in the future as probiotics are free from triggering any adverse effects in human body.

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“…Prebiotic inulin and dietary inulin may suppress inflammation and modulate gut macrobiotics during T2DM progression ( 81 ). In AD patients, cognitive function was improved after treatment with probiotics containing Lactobacillus and Bifidobacterium ( 82 , 83 ).…”

Section: Nutritional Intervention Improves Dm Accompanied With Admentioning

confidence: 99%

Nutritional intervention for diabetes mellitus with Alzheimer's disease

Xiao

et al. 2022

Front. Nutr.

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The combined disease burden of diabetes mellitus (DM) and Alzheimer's disease (AD) is increasing, and the two diseases share some common pathological changes. However, the pharmacotherapeutic approach to this clinical complexity is limited to symptomatic rather than disease-arresting, with the possible exception of metformin. Whether nutritional intervention might extend or synergize with these effects of metformin is of interest. In particular, dietary patterns with an emphasis on dietary diversity shown to affect cognitive function are of growing interest in a range of food cultural settings. This paper presents the association between diabetes and AD. In addition, the cross-cultural nutritional intervention programs with the potential to mitigate both insulin resistance (IR) and hyperglycemia, together with cognitive impairment are also reviewed. Both dietary patterns and nutritional supplementation showed the effects of improving glycemic control and reducing cognitive decline in diabetes associated with AD, but the intervention specificity remained controversial. Multi-nutrient supplements combined with diverse diets may have preventive and therapeutic potential for DM combined with AD, at least as related to the B vitamin group and folate-dependent homocysteine (Hcy). The nutritional intervention has promise in the prevention and management of DM and AD comorbidities, and more clinical studies would be of nutritional scientific merit.

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Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice

Cited by 28 publications

References 63 publications

Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

Probiotics for Alzheimer’s Disease: A Systematic Review

Nutritional intervention for diabetes mellitus with Alzheimer's disease

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