Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity

Hanssen, Henner; Nickel, Thomas; Drexel, Verena; Hertel, G.; Emslander, I.; Sisic, Zeljka; Lorang, D.; Schuster, Tibor; Kotliar, Konstantin; Preßler, Axel; Schmidt‐Trucksäss, Arno; Weis, Michael; Halle, Martin

doi:10.1016/j.atherosclerosis.2011.02.009

Cited by 89 publications

(105 citation statements)

References 32 publications

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“…In agreement with the present study, exercise-induced decreases in systemic ADMA concentration have been previously reported in different populations [19,21,[24][25][26][27]. Moderate-intensity, supervised exercise has shown to decrease plasma ADMA concentration in individuals with elevated cardiovascular risk [19], including peripheral arterial disease [26], chronic heart failure [27], obesity [25], and type 1 diabetes [21].…”

Section: Discussionsupporting

confidence: 79%

“…These improvements were accompanied by significant decreases in both systolic and diastolic blood pressure (BP) following twelve weeks of exercise. The exercise-induced reductions in ADMA plasma concentration has been reported elsewhere [19,21,[24][25][26][27], the mechanisms behind this process are not clear. ADMA's cardiovascular effects include vasoconstriction and increased blood pressure [30,31] BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA 1c , glycated hemoglobin; TE, time to exhaustion; VO 2 peak, peak oxygen uptake; HR, heart rate; V E , ventilation; VO 2 T ge , oxygen uptake at gas-exchange threshold; RER, respiratory exchange ratio.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, decreased ADMA concentration following exercise training has been shown to be accompanied by enhanced DDAH-1 mRNA gene-expression [25]. Upregulation of DDAH-1 and subsequent decreased ADMA concentration through regular exercise may be influenced by antioxidant status.…”

Section: Discussionmentioning

confidence: 99%

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Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

Serre

Simmonds²,

Sabapathy³

et al. 2012

Endocrinol Metabol Syndrome

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Aims/hypothesis: Basal plasma concentration of asymmetric dimethylarginine (ADMA), an endogenous, competitive inhibitor of nitric oxide synthase, is elevated in patients with type 2 diabetes. ADMA may contribute to the endothelial dysfunction and associated vascular complications observed in individuals with type 2 diabetes. The present study investigated the effect of 12 weeks of supervised walking exercise on plasma ADMA concentration in women aged 65-74 years with type 2 diabetes. Materials and methods:Fourteen women (aged 69 ± 3 yrs) with uncomplicated type 2 diabetes, completed 12 weeks of supervised, moderate-intensity walking at an intensity equivalent to their individual gas-exchange threshold. Blood was sampled for ADMA concentration before and after a 6-week intervention-free control period, and again after 6 and 12 weeks of exercise training.Results: Plasma ADMA concentration was found to be significantly lower after 12-weeks of exercise training when compared with baseline (0 wk) measurements. These results were accompanied by significant increases in time to exhaustion, relative and absolute peak oxygen uptake, and oxygen uptake at gas-exchange threshold. Conclusion/interpretation:Regular, moderate-intensity exercise decreases circulating ADMA concentrations in older women with type 2 diabetes. These results suggest that ADMA may play a role in the training-induced reduction in cardiovascular disease risk seen with exercise training in individuals with type 2 Diabetes.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

Serre

Simmonds²,

Sabapathy³

et al. 2012

Endocrinol Metabol Syndrome

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“…In large population-based cross-sectional studies, lower levels of physical activity are associated with wider retinal venules (Tikellis et al 2010; Anuradha et al 2011). In the only available chronic exercise intervention study, we have previously shown that higher physical fitness levels are associated with higher retinal AVR and that regular endurance exercise induces arteriolar dilatation and venular constriction in middle-aged lean and obese individuals (Hanssen et al 2011). …”

Section: Introductionmentioning

confidence: 99%

Effects of acute bouts of endurance exercise on retinal vessel diameters are age and intensity dependent

Nussbaumer

Donath

Fischer

et al. 2014

AGE

Self Cite

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Alterations of retinal vessel diameters are associated with increased cardiovascular risk. We aimed to investigate changes in retinal vessel diameters in response to acute dynamic exercise of different intensities and whether these changes are age dependent. Seventeen healthy seniors (median (IQR) age 68 (65, 69) years) and 15 healthy young adults (median (IQR) age 26 (25, 28) years) first performed a maximal treadmill test (MTT) followed by a submaximal treadmill test (SMTT) and a resting control condition in randomised order. Central retinal arteriolar (CRAE) and central retinal venular (CRVE) diameter equivalents were measured before as well as 5 (t5) and 40 (t40) minutes after exercise cessation using a static retinal vessel analyser. Both exercise intensities induced a significant dilatation in CRAE and CRVE at t5 compared to the control condition (P < 0.001). At t40, the mean increase in CRAE and CRVE was greater for MTT compared to that for SMTT (CRAE 1.7 μm (95 % confidence interval (CI) −0.1, 3.6; P = 0.061); CRVE 2.2 μm (95 % CI 0.4, 4.1; P = 0.019)). However, the estimated difference at t5 between seniors and young adults in their response to MTT compared to SMTT was 5.3 μm (95 % CI 2.0, 8.5; P = 0.002) for CRAE and 4.1 μm (95 % CI −0.4, 8.6; P = 0.076) for CRVE. Wider arteries and veins after maximal versus submaximal exercise for seniors compared to young adults suggest that myogenic vasoconstriction in response to exhaustive exercise may be reduced in seniors. Age-related loss of vascular reactivity has clinical implications since the arteriolar vasoconstriction protects the retinal capillary bed from intraluminal pressure peaks.Electronic supplementary materialThe online version of this article (doi:10.1007/s11357-014-9650-3) contains supplementary material, which is available to authorized users.

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“…Auch an den retinalen Gefäßen konnte bei adipösen Personen mit erhöhtem Bauchumfang (106  5 cm) eine Normalisierung der arterio-venösen Ratio, einem Risikoindikator für kardiovaskuläre Ereignisse, nach 10-wöchigem Ausdauertraining erzielt werden. Das deutet zusammen mit der Reduzierung von asymmetrischen Dimethylarginin (ADMA), einem endogenen Inhibitor der NO-Synthase, auf eine verbesserte Endothelfunktion hin [10].…”

Section: Einfluss Von Körperlicher Aktivitätunclassified

Vaskuläres Altern, Hypertonie und körperliche Aktivität

Schmidt‐Trucksäss

Weisser

2011

Dtsch med Wochenschr

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The present review delineates the significance of intima-media-thickness, arterial stiffness and endothelial function for vascular aging. There is profound evidence for an increase in intima-media-thickness and vascular stiffness not only during healthy aging but induced also by cardiovascular risk factors. There is a central role of arterial hypertension for this progression in both structural factors. In addition, both parameters are strongly associated with cardiovascular risk. Endothelial function measured as postischemic flow-mediated vasodilatation is a functional parameter which is decreased both in healthy aging and by cardiovascular risk factors. Physical activity modifies the influence of aging and risk factors on endothelial function. A positive influence of endurance exercise on vascular stiffness and endothelial function has been demonstrated in numerous studies. In long-term studies, regular physical activity has been shown to reduce the progression of intima-media-thickness. Thus, arterial hypertension accelerates vascular aging, while physical activity has a positive influence on a variety of vascular parameters associated with vascular aging.

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Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity

Cited by 89 publications

References 32 publications

Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

Effects of acute bouts of endurance exercise on retinal vessel diameters are age and intensity dependent

Vaskuläres Altern, Hypertonie und körperliche Aktivität

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