Exercise training ameliorates the effects of rosiglitazone on traditional and novel cardiovascular risk factors in patients with type 2 diabetes mellitus

Kadoglou, Nikolaos P.E.; Iliadis, Fotios; Sailer, Nikolaos; Athanasiadou, Zoi; Vitta, Ioulia; Kapelouzou, Alkistis; Karayannacos, Panayotis E.; Liapis, Christos D.; Alevizos, Miltiadis; Angelopoulou, Nickoletta; Vrabas, Ioannis S.

doi:10.1016/j.metabol.2009.09.002

Cited by 48 publications

(41 citation statements)

References 47 publications

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“…As shown in ESM Table 1, across 20 interventions of aerobic exercise training, [8,9,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] the mean exercise frequency was three sessions per week, mean session duration was 48 min (not including warm-up and cool down), and mean exercise intensity was 74% of the HR max . In six trials (33%), exercise intensity was transformed from submaximal rates of V : O 2peak to the corresponding percentages of HR max .…”

Section: Resultsmentioning

confidence: 99%

“…Across the ten trials of combined exercise training [6,8,9,23,26,32,[41][42][43][44], the mean exercise frequency was three sessions per week (minimum-maximum: two to four sessions), mean session duration was 59 min (minimum-maximum: 45-90 min), mean aerobic exercise intensity was 73% of the HR max (minimum-maximum: 60-85%), whereas resistance exercise intensity in each set ranged from 40% to 85% of the 1-RM. We were unable to extract or derive exercise intensity in eight interventions of aerobic training [22][23][24][25][26][27][28][29] and three interventions of combined training [23,26,41]. These studies were included in the systematic review, but their data were not entered in the analyses assessing exercise intensity as a covariate.…”

Section: Resultsmentioning

confidence: 99%

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Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis

et al. 2012

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Aims/hypothesis Supervised exercise programmes improve glycaemic control in type 2 diabetes, but training characteristics associated with reduction in HbA 1c remain unclear. We conducted a systematic review with meta-regression analysis of randomised clinical trials (RCTs) assessing the association between intensity and volume of exercise training (aerobic, resistance or combined) and HbA 1c changes in patients with type 2 diabetes. Methods Five electronic databases were searched to retrieve RCTs of at least 12 weeks' duration, consisting of supervised exercise training vs no intervention, that reported HbA 1c changes and exercise characteristics. Two independent reviewers conducted study selection and data extraction.Results Twenty-six RCTs (2,253 patients) met the inclusion criteria. In multivariate analysis, baseline HbA 1c and exercise frequency explained nearly 58% of between-study variance. Baseline HbA 1c was inversely correlated with HbA 1c reductions after the three types of exercise training. In aerobic training, exercise volume (represented by frequency of sessions) was associated with changes in HbA 1c (weighted r0−0.64), while no variables were correlated with glycaemic control induced by resistance training. In combined training, weekly volume of resistance exercise explained heterogeneity in multivariate analysis and was associated with changes in HbA 1c levels (weighted r0−0.70). Conclusions/interpretation Reduction in HbA 1c is associated with exercise frequency in supervised aerobic training, and with weekly volume of resistance exercise in supervised combined training. Therefore, exercise volume is a major determinant of glycaemic control in patients with type 2 diabetes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis

et al. 2012

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“…According to the results of previous clinical studies, weight loss mediated by calorie-restricted diet interventions [43], Mediterranean-like diets, and omega-3 fatty acid supplementation [44], or combined interventions with diet and exercise [45,46], were reported to decrease IL-18 levels [40]. Aerobic exercise has been reported to reduce circulating levels of IL-18 in patients with type 2 diabetes [18,19] and IL-18 expression in adipose tissue in obese subjects [47]. …”

Section: Resultsmentioning

confidence: 99%

“…IL-18 is secreted constitutively in many different cell types in the adipose tissue, including macrophages, vascular endothelial cells, vascular smooth muscle cells, and adipocytes [16,17]. On the other hand, aerobic exercise has been reported to reduce levels of CRP and IL-18 in subjects with type 2 diabetes [18,19]. …”

Section: Introductionmentioning

confidence: 99%

Circulating interleukin-18: A specific biomarker for atherosclerosis-prone patients with metabolic syndrome

et al. 2011

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BackgroundMetabolic syndrome (MetS) is associated with an increased risk of the development of atherosclerotic cardiovascular disease (CVD). Interleukin-18 (IL-18), which is a pleiotropic proinflammatory cytokine with important regulatory functions in the innate immune response system, plays a crucial role in vascular pathologies. IL-18 is also a predictor of cardiovascular death in patients with CVD and is involved in atherosclerotic plaque destabilization.ResultsIn order to determine if circulating levels of IL-18 can serve as a specific biomarker for distinguishing MetS patients from pre-MetS subjects, we studied 78 patients with visceral fat deposition and 14 age-matched control subjects. Increased levels of IL-18 were observed more frequently in patients with MetS than in pre-MetS subjects and were positively associated with waist circumference. Serum levels of IL-18 were significantly reduced by a change in weight caused by lifestyle modifications. There was a significant interaction between waist circumference and serum IL-18 concentration. Weight loss of at least 5% of the body weight caused by lifestyle modification decreased IL-18 circulating levels relative to the reduction in waist circumference and blood pressure, suggesting that this degree of weight loss benefits the cardiovascular system.ConclusionIL-18 may be a useful biomarker of the clinical manifestations of MetS and for the management of the risk factors of CVD.

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“…Aerobic exercise has been reported to reduce levels of CRP and IL-18 in subjects with type 2 diabetes [95,96]. In another study, aerobic exercise, but not strength training, reduced circulating levels of CRP, IL-6 and IL-18 in older subjects [97].…”

Section: Introductionmentioning

confidence: 99%

The role of interleukin-18 in the metabolic syndrome

Trøseid

Seljeflot

Arnesen

2010

Cardiovasc Diabetol

136

108

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The metabolic syndrome is thought to be associated with a chronic low-grade inflammation, and a growing body of evidence suggests that interleukin-18 (IL-18) might be closely related to the metabolic syndrome and its consequences. Circulating levels of IL-18 have been reported to be elevated in subjects with the metabolic syndrome, to be closely associated with the components of the syndrome, to predict cardiovascular events and mortality in populations with the metabolic syndrome and to precede the development of type 2 diabetes. IL-18 is found in the unstable atherosclerotic plaque, in adipose tissue and in muscle tissue, and is subject to several regulatory steps including cleavage by caspase-1, inactivation by IL-18 binding protein and the influence of other cytokines in modulating its interaction with the IL-18 receptor. The purpose of this review is to outline the role of IL-18 in the metabolic syndrome, with particular emphasis on cardiovascular risk and the potential effect of life style interventions.

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Exercise training ameliorates the effects of rosiglitazone on traditional and novel cardiovascular risk factors in patients with type 2 diabetes mellitus

Cited by 48 publications

References 47 publications

Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis

Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis

Circulating interleukin-18: A specific biomarker for atherosclerosis-prone patients with metabolic syndrome

The role of interleukin-18 in the metabolic syndrome

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