Exfoliative dermatitis. A clinicopathologic study of 135 cases

Nicolis, G.; Helwig, Elson B.

doi:10.1001/archderm.108.6.788

Cited by 81 publications

(77 citation statements)

References 19 publications

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“…Except that eosinophilia was found in 66% of drug induced erythroderma cases, the use of laboratory evaluation to differentiate the various causes of erythroderma has generally not been helpful in this study as in various other series. 8,9,12,13 In this study, 84% (30/36) of the patients had pre-existing dermatoses, 42% constituted by psoriasis and 42% by eczemas. Among these, 90% (27/30) had aggravation of their disease prior to exfoliation.…”

mentioning

confidence: 51%

Clinical profile, etiology and histopathology of patients with erythroderma in South India

Snigdha¹,

George²,

Binitha³

et al. 2017

Int J Res Dermatol

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Background: Erythroderma is a generalised inflammatory disorder of skin manifesting with erythema and scaling affecting more than 90% of the skin surface. Several studies have highlighted the importance of biopsy in the diagnosis and management of erythroderma, while some others have found it to be of limited use.Methods: Thirty-six patients with erythroderma were enrolled in the study and a detailed history, clinical examination and relevant investigations including skin biopsy was done to find out the etiology.Results: Pre-existing dermatoses were the predominant cause (84%) contributed equally by psoriasis (42%) and eczemas (42%) and clinicopathologic correlation could be obtained in 30.55% of cases.Conclusions: Our study showed that skin biopsy remains a valuable tool in the diagnosis of erythroderma.

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mentioning

confidence: 51%

Clinical profile, etiology and histopathology of patients with erythroderma in South India

Snigdha¹,

George²,

Binitha³

et al. 2017

Int J Res Dermatol

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“…This extensive inflammatory skin disorder may be associated with an underlying malignancy in 1% to 11% of patients. [3][4][5][6][7][8][9][10] The most common malignancy in this setting is cutaneous T-cell lymphoma comprising mycosis fungoides and Sezary syndrome. Although case reports of erythroderma in association with carcinoma of liver, prostate, colon, breast and thyroid have been infrequently described, its occurrence as a presenting feature of solid tumors of the lung is extremely rare.…”

Section: Discussionmentioning

confidence: 99%

“…Although case reports of erythroderma in association with carcinoma of liver, prostate, colon, breast and thyroid have been infrequently described, its occurrence as a presenting feature of solid tumors of the lung is extremely rare. [6][7][8][9][10][11][12] Gupta et al reported a case of erythroderma secondary to carcinoma lung with presenting features of pain in lower extremities with thickening and desquamation of skin in palms. 13 Paraneoplastic dermatoses usually become apparent at the same time as the tumor and run a parallel course.…”

Section: Discussionmentioning

confidence: 99%

Erythroderma: a marker for visceral malignancy: rare case report

et al. 2017

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Skin can provide a vital clue to diagnosis of internal disease. Exfoliative dermatitis (erythroderma) is an uncommon potentially serious inflammatory skin disorder characterized by an intense, widespread erythema and variable scaling. It results from aggravation of pre-existing skin disease, or may be caused by drugs or neoplasms. Although various paraneoplastic dermatoses may occur in association with carcinoma lung, erythroderma as the sole presenting feature is infrequently reported in literature. Herein we describe an elderly male in whom recalcitrant erythroderma led to the diagnosis of squamous cell carcinoma lung with fatal outcome.

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“…[15] The skin biopsy has been reported to be of varying usefulness in making a diagnosis. [15] [16] As stated earlier the biopsy site will depend on the type of elementary lession, but in general, incisional biopsy is preferred and will be at the center of the tumor and inflammatory lesions, in the annular rim of annular lesions and shall include center and border in ulcers areas. In the case of pigmented lesions excisional biopsy is preferred.…”

Section: Introductionmentioning

confidence: 99%