Exhaled nitric oxide level decreases after cardiopulmonary bypass in adult patients

Abstract

Measurement of exhaled NO as VNO, which was associated with lung dysfunction, may be an indicator of lung injury in adult patients after cardiopulmonary bypass.

Plasma cytokines do not reflect expression of pro‐ and anti‐inflammatory cytokine mRNA at organ level after cardiopulmonary bypass in neonatal pigs*

“…Moreover, there was also an equal decrease in expiratory NO in the two groups that terminated 0.5 h post-CPB. This decrease in exhaled NO after CPB is in accordance with human studies (16).…”

Comparison of Pulmonary Gas Exchange in OPCAB Versus Conventional CABG

“…The increase in V NO was consistent with the physiological recovery of pulmonary functions. 16 As exhaled nitric oxide levels decrease with worsening oxygenation, such a measurement has the potential of a near patient test, which can alert the clinicians to developing acute lung injury. 17 Despite all the theoretical reasons for more severe lung injury in conventional CABG, no difference has been found so far between conventional and OPCAB surgery in regards to pulmonary gas exchange abnormalities.…”

Hemodynamic effects of inhaled nitric oxide and phosphodiesterase inhibitor (dipyridamole) on secondary pulmonary hypertension following heart valve surgery in adults

“…Among different possible acting mechanisms, it was also considered that an initial exogenous dose of iNO might compensate for the demonstrated diminished expression of endothelial NO activity of pulmonary vessels in patients with PH [2], as also shown by the decreased level of exhaled NO particularly after cardiopulmonary bypass [24]. With increasing knowledge on the biological chemistry of NO derived from animal models and monitored clinical applications, it became soon evident that the potential benefits of iNO were limited to its continuous administration and rapidly disappeared after discontinuation, often with catastrophic rebound effects [25][26][27].…”