As an economic, social, and cultural activity, tourism shapes the relationship between visitors and local communities in tourist destinations. While tourism generates economic growth and employment opportunities for residents, its benefits come with a social cost. This article highlights the results of an online survey that was carried out at the beginning of 2021 in the seven major Galician cities along the Route of Santiago de Compostela (the Way of St. James) in Spain, which is a historical, natural, and cultural tourist attraction that is inscribed in the UNESCO’s World Heritage List in the category of cultural assets. The goal of the research work was to get to know first-hand the opinion of local communities about the positive and negative effects of tourism in their cities, on the Route of Santiago, and in the region of Galicia as a whole. Research work shows that residents’ perception of tourism leans toward the positive side, although it also reveals the need for tourism planners to involve host communities in tourism development. This research study about a World Heritage site should prove useful for political decision makers, tourism planners, and experts, both in Galicia and elsewhere.