Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia

Poynter, Jenny N.; Fonstad, Rachel; Blair, Cindy K.; Roesler, Michelle A.; Cerhan, James R.; Hirsch, Betsy A.; Nguyen, Phuong L.; Ross, Julie A.

doi:10.1038/bjc.2013.507

Cited by 7 publications

(7 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to our findings for MPN, Poynter, et al (17) found no association between the use of HT and risk of myeloid leukemia (AML or CML). Similarly, in the IWHS cohort, Ross, et al (18) found no associations between ever use of HT and risk of AML.…”

Section: Discussioncontrasting

confidence: 99%

“…We are not aware of other studies in myeloid malignancies that have specifically analyzed quartiles of ovulatory years; other investigators have reported associations of age at menarche, parity, and OC use with mixed results. Poynter, et al (17) found no association between age at menarche, parity, OC use or menopausal status with risk of CML, however, they found a reduced risk of AML among those that were premenopausal at diagnosis and OC use for >5 years (OR=0.55; 95% CI 0.32–0.96). Conversely, Traversa, et al (29) reported a non-significant increased risk of acute leukemia among their cohort of women who had filled at least one OC prescription.…”

Section: Discussionmentioning

confidence: 99%

“…Reproductive factors, including age at menarche (7, 9, 10, 16), age at menopause (5, 8, 16), age at first live birth (7, 9, 10, 16) and nulliparity (9, 16), have largely shown no association with NHL risk, which was also found in an InterLymph pooled analysis (14). Although fewer in number, studies of acute myeloid leukemia (AML) have shown no association with use of HT (17, 18), age at menarche (17) or parity (17, 19), while one study showed a weak inverse association between OC use and risk of AML (17). One study showed a weak inverse association between parity and age at first birth in chronic myelogenous leukemia (CML) (19).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hormonal and Reproductive Factors and Risk of Myeloproliferative Neoplasms in Postmenopausal Women

Leal

Thompson

Wang

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background Hormonal and reproductive history has been associated with risk of some hematologic malignancies, but their role in myeloproliferative neoplasms (MPN) is largely unknown. Methods Using a population-based cohort study, we evaluated the association of these factors with risk of MPN overall, and for essential thrombocythemia (ET) and polycythemia vera (PV) specifically. Incident MPN cases from 1993–2004 were identified via linkage to Medicare. Relative risks (RR) and 95% confidence intervals (CI) were estimated utilizing Cox proportional hazard regression. Results After >250,000 person-years of follow-up, 257 cases of MPN were identified (172 ET, 64 PV). Ever use of hormone therapy (HT) was associated with an increased risk of ET (RR=1.63; 95%CI 1.19–2.23) but a decreased risk of PV (RR=0.58; 95%CI 0.34–0.98). There were no statistically significant associations of oral contraceptives or reproductive factors with MPN risk overall, or by MPN subtype. Bilateral oophorectomy was associated with increased risk of ET (RR=1.58; 95%CI 1.11–2.25) and decreased risk of PV (RR=0.32; 95%CI 0.12–0.88). There was no association of ovulatory years with ET risk, however there was increased risk of PV (RR=1.68 for >36.8 compared to ≤27.6 years; p-trend=0.045). Adjustment for potential confounding factors did not alter these associations. Conclusions HT use and bilateral oophorectomy had opposite associations for ET and PV. Except for ovulatory years and PV risk, reproductive history did not appear to play a role in the etiology of MPN.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hormonal and Reproductive Factors and Risk of Myeloproliferative Neoplasms in Postmenopausal Women

Leal

Thompson

Wang

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…In addition, the role of estrogen in hematopoietic diseases has long been controversial. Traversa G et al [ 24 ] have found that oral contraceptives are a potential risk factor for AML, but Poynter et al [ 25 ] have analyzed the clinical data and found that the risk of postmenopausal AML declines in people who take oral contraceptives for more than five years. The reasons for these inconsistent research results may be associated with the region and age distribution of the population.…”

Section: Discussionmentioning

confidence: 99%

Estrogens revert neutrophil hyperplasia by inhibiting Hif1α-cMyb pathway in zebrafish myelodysplastic syndromes models

Wang

Qin

et al. 2022

Cell Death Discov.

View full text Add to dashboard Cite

Myelodysplastic syndromes (MDS) are characterized by daunting genetic heterogeneity and a high risk of leukemic transformation, which presents great challenges for clinical treatment. To identify new chemicals for MDS, we screened a panel of FDA-approved drugs and verified the neutrophil hyperplasia inhibiting role of 17β-estradiol (E2, a natural estrogen) in several zebrafish MDS models (pu.1G242D/G242D, irf8Δ57Δ/57 and c-mybhyper). However, the protective mechanism of estrogen in the development of hematological malignancies remains to be explored. Here, analyzing the role of E2 in the development of each hematopoietic lineage, we found that E2 exhibited a specific neutrophil inhibiting function. This neutrophil inhibitory function of E2 is attributed to its down-regulation of c-myb, which leads to accelerated apoptosis and decreased proliferation of neutrophils. We further showed that knockdown of hif1α could mimic the neutrophil inhibiting role of E2, and hif1α overexpression could reverse the protective function of E2. Collectively, our findings highlight the protective role of E2 on MDS by inhibiting hif1α-c-myb pathway, suggesting that E2 is a promising and effective drug for hematopoietic tumors associated with abnormal neutrophil hyperplasia.

show abstract

“…Although the findings were based on only a few rat carcinogens this result may indicate a potentially important mechanism for cancer development in this organ, possibly also for humans. Although there are articles reporting on potential links between hormonally active substances and cancer of the hematopoietic system in humans ( Traversa et al, 1998 ; Poynter et al, 2013 ; Leal et al, 2016 ), the aetiologies of this cancer type are still unclear ( Laurier et al, 2014 ). More research is required to support these findings and it would, e.g., be of interest to evaluate the structures of the chemicals in more details and investigate potential links with hormonal receptors.…”

Section: Discussionmentioning

confidence: 99%

Combining QSAR Modeling and Text-Mining Techniques to Link Chemical Structures and Carcinogenic Modes of Action

Papamokos

Silins

2016

Front. Pharmacol.

View full text Add to dashboard Cite

There is an increasing need for new reliable non-animal based methods to predict and test toxicity of chemicals. Quantitative structure-activity relationship (QSAR), a computer-based method linking chemical structures with biological activities, is used in predictive toxicology. In this study, we tested the approach to combine QSAR data with literature profiles of carcinogenic modes of action automatically generated by a text-mining tool. The aim was to generate data patterns to identify associations between chemical structures and biological mechanisms related to carcinogenesis. Using these two methods, individually and combined, we evaluated 96 rat carcinogens of the hematopoietic system, liver, lung, and skin. We found that skin and lung rat carcinogens were mainly mutagenic, while the group of carcinogens affecting the hematopoietic system and the liver also included a large proportion of non-mutagens. The automatic literature analysis showed that mutagenicity was a frequently reported endpoint in the literature of these carcinogens, however, less common endpoints such as immunosuppression and hormonal receptor-mediated effects were also found in connection with some of the carcinogens, results of potential importance for certain target organs. The combined approach, using QSAR and text-mining techniques, could be useful for identifying more detailed information on biological mechanisms and the relation with chemical structures. The method can be particularly useful in increasing the understanding of structure and activity relationships for non-mutagens.

show abstract

Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia

Cited by 7 publications

References 17 publications

Hormonal and Reproductive Factors and Risk of Myeloproliferative Neoplasms in Postmenopausal Women

Hormonal and Reproductive Factors and Risk of Myeloproliferative Neoplasms in Postmenopausal Women

Estrogens revert neutrophil hyperplasia by inhibiting Hif1α-cMyb pathway in zebrafish myelodysplastic syndromes models

Combining QSAR Modeling and Text-Mining Techniques to Link Chemical Structures and Carcinogenic Modes of Action

Contact Info

Product

Resources

About