Exosomal miR-655-3p inhibits growth, and invasion and macrophage M2 polarization through targeting CXCR4  in papillary thyroid carcinoma

Qiao, Lei; Chen, Dong; Jia, Wenlei; Ma, Binlin

doi:10.18388/abp.2020_6027

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…Other pathways involved in macrophage recruitment include CXCL12-CXCR4 and angiopoietin 2 (ANG2)–TIE2 axis ( 57 – 59 ). Therefore, depletion of TEM could cause vascular destruction, neutralization of ANG2 can improve the response to vascular VEGFA blockade, and inhibition of TEM recruitment can inhibit tumor growth ( 60 ).…”

Section: Targeting Macrophages In the Tumor Microenvironmentmentioning

confidence: 99%

New insights into the role of macrophages in cancer immunotherapy

Zhou,

Zhao,

Zhang

et al. 2024

Front. Immunol.

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Macrophages are the main component of the tumor microenvironment, which are differentiated from monocytes in the blood and play an important role in cancer development. Tumor-associated macrophages (TAMs) can promote tumor growth, invasion, metastasis, and resistance to anti–programmed death receptor 1 therapy by regulating programmed cell death ligand 1 expression and interacting with other immune cells in the tumor microenvironment. However, when activated properly, macrophages can also play an anti-tumor role by enhancing the phagocytosis and cytotoxicity of tumor cells. TAM is associated with poor prognosis and drug resistance in patients treated with immunotherapy, indicating that macrophages are attractive targets for combined therapy in cancer treatment. Combination of targeting TAMs and immunotherapy overcomes the drug resistance and achieved excellent results in some cancers, which may be a promising strategy for cancer treatment in the future. Herein, we review the recent findings on the role of macrophages in tumor development, metastasis, and immunotherapy. We focus mainly on macrophage≥centered therapy, including strategies to deplete and reprogram TAMs, which represent the potential targets for improving tumor immunotherapy efficacy.

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Section: Targeting Macrophages In the Tumor Microenvironmentmentioning

confidence: 99%

New insights into the role of macrophages in cancer immunotherapy

Zhou,

Zhao,

Zhang

et al. 2024

Front. Immunol.

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“…Exosomes miR-655-3p inhibits growth, invasion, and macrophage M2 polarization in papillary thyroid carcinoma by targeting CXCR4. The results indicated that the regulation of exosomes miR-655-3p/CXCR4 may be a potential therapeutic strategy for PTC ( 162 ). Some scholars have also conducted corresponding research on the relationship between extracellular miRNAs and drug resistance.…”

Section: Therapeutic Role Of Macrophage Polarization Induced By Mirna...mentioning

confidence: 97%

“…Papillary thyroid cancer (PTC) is an endocrine malignancy, and the role and molecular mechanism of miR-655-3p in PTC are currently unclear. A study conducted by Qiao et al ( 162 ) revealed that overexpression of miR-655-3p with mimics significantly reduced tumor cell viability, chemotaxis and invasiveness. Exosomes miR-655-3p inhibits growth, invasion, and macrophage M2 polarization in papillary thyroid carcinoma by targeting CXCR4.…”

Section: Therapeutic Role Of Macrophage Polarization Induced By Mirna...mentioning

confidence: 99%

The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review)

Wang,

Zhang

et al. 2023

Oncol Rep

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The characteristics of monocyte/macrophage lineage are diversity and plasticity, mainly manifested by M1 and M2 subtypes in the body tissues, and playing different roles in the immunity. In the polarization process of macrophages, the classic molecular mechanism is related to sequential transcription factors. Whether in tumor or inflammatory local microenvironment, the pathological factors of the local microenvironment often affect the polarization of M1 and M2 macrophages, and participate in the occurrence and development of these pathological processes. In recent years, a growing number of research results demonstrated that non-coding RNA (ncRNA) also participates in the polarization process of macrophages, in addition to traditional cytokines and transcriptional regulation signal pathway molecules. Among numerous ncRNAs, microRNAs (miRNAs) have attracted more attention from scholars both domestically and internationally, and significant progress has been made in basic and clinical research. Therefore, for improved understanding of the molecular mechanism of miRNAs in macrophage polarization and analysis of the potential value of this regulatory pathway in tumor and inflammatory intervention therapy, a comprehensive review of the progress of relevant literature research was conducted and some viewpoints and perspectives were proposed.

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