Exosomes and Nano-SDF Scaffold as a Cell-Free-Based Treatment Strategy Improve Traumatic Brain Injury Mechanisms by Decreasing Oxidative Stress, Neuroinflammation, and Increasing Neurogenesis

Hajinejad, Mehrdad; Ebrahimzadeh, Mohammad H.; Ebrahimzadeh‐Bideskan, Alireza; Rajabian, Arezoo; Gorji, Ali; Negah, Sajad Sahab

doi:10.1007/s12015-022-10483-0

Cited by 14 publications

(6 citation statements)

References 60 publications

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“…The comprehensive review of exosome-based therapy research underscores its efficacy in promoting neurorepair and neurogenesis. Notably, the intriguing prospect of augmenting these effects through the combination of exosomes with 3D scaffolds represents a promising avenue for further research and holds significant potential for advancing therapeutic approaches in the field of neurological regenerative medicine [ 440 ].…”

Section: Exosomes In Regenerative Medicine: Tissue-specific Applicationsmentioning

confidence: 99%

Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade

Moghassemi,

Dadashzadeh,

Sousa

et al. 2024

Bioactive Materials

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Section: Exosomes In Regenerative Medicine: Tissue-specific Applicationsmentioning

confidence: 99%

Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade

Moghassemi,

Dadashzadeh,

Sousa

et al. 2024

Bioactive Materials

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“…[81] Finally, Hajinejad et al used a 3D nano-scaffold containing a biomotif of stromal cell-derived factor (SDF)−1𝛼 for the local delivery of NSC-derived sEVs in a TBI animal model. [82] This smart system attenuated oxidative stress through the TLR4/NF-𝜅B/IL-1𝛽 pathway, decreased reactive gliosis-related neuroinflammation, and increased neurogenesis through a bio-bridge mechanism.…”

Section: Traumatic Brain Injurymentioning

confidence: 99%

Biomaterial‐Facilitated Local Delivery of Stem Cell‐Derived Small Extracellular Vesicles: Perspectives in Surgical Therapy

Tan,

Xu,

et al. 2024

Advanced Therapeutics

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Stem cell‐derived small extracellular vesicles that are either naturally produced or pharmacogenetically engineered have shown tremendous potential in regenerative medicine in recent years. These sEVs exert multiple therapeutic effects comparable or superior to their parental stem cells while avoiding the limitations of stem cell‐based therapy, such as infusion toxicity, immunogenicity, tumorigenic potential, and ethical issues. The two routine modalities of sEV administration are systemic injection and local delivery, each presenting distinct benefits and drawbacks. Various biomaterials have been developed to assist their local delivery to improve the targeting of organs, minimize non‐specific accumulation in vital organs, and ensure the protection and release of sEVs. Based on a thorough search and meticulous dissection of relevant literature from the past five years, we present this comprehensive, up‐to‐date, specialty‐specific, disease‐oriented, and preclinical review to expound on the surgical application and potential of stem cell‐derived sEVs. The local delivery of stem cell‐derived sEVs, which possess similar indications as systemic transfer, could treat numerous diseases encountered in orthopedic surgery, neurosurgery, plastic surgery, cardiothoracic surgery, general surgery, urology, otorhinolaryngology, ophthalmology, obstetrics and gynecology, and dental surgery. In addition, the biomaterials utilized encompass a wide range of sources (e.g., natural, synthetic, and hybrid polymers), format (e.g., scaffold, patch, spray, microneedle), and responsiveness (e.g., temperature, pH, and protein), which enables customized sEV therapy tailored to specific diseases. This review demonstrates biomaterial‐facilitated local delivery of stem cell‐derived sEVs as a viable alternative or even a superior option to systemic sEV therapy. Future collaboration among surgeons, biomaterial scientists, and stem cell researchers is essential to advance this research area.This article is protected by copyright. All rights reserved

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“…These biomarkers, along with indicators of neuroinflammation, may shed light on the factors contributing to TBI's progression to AD and the biological response to therapeutic interventions. Growing experimental evidence suggests that EVs are potentially useful in therapeutic interventions [189][190][191].…”

Section: Cns Injuriesmentioning

confidence: 99%

Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

Choi,

Chen,

Goldston

et al. 2024

Nano Convergence

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Central Nervous System (CNS) disorders represent a profound public health challenge that affects millions of people around the world. Diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and traumatic brain injury (TBI) exemplify the complexities and diversities that complicate their early detection and the development of effective treatments. Amid these challenges, the emergence of nanotechnology and extracellular vesicles (EVs) signals a new dawn for treating and diagnosing CNS ailments. EVs are cellularly derived lipid bilayer nanosized particles that are pivotal in intercellular communication within the CNS and have the potential to revolutionize targeted therapeutic delivery and the identification of novel biomarkers. Integrating EVs with nanotechnology amplifies their diagnostic and therapeutic capabilities, opening new avenues for managing CNS diseases. This review focuses on examining the fascinating interplay between EVs and nanotechnology in CNS theranostics. Through highlighting the remarkable advancements and unique methodologies, we aim to offer valuable perspectives on how these approaches can bring about a revolutionary change in disease management. The objective is to harness the distinctive attributes of EVs and nanotechnology to forge personalized, efficient interventions for CNS disorders, thereby providing a beacon of hope for affected individuals. In short, the confluence of EVs and nanotechnology heralds a promising frontier for targeted and impactful treatments against CNS diseases, which continue to pose significant public health challenges. By focusing on personalized and powerful diagnostic and therapeutic methods, we might improve the quality of patients.

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Exosomes and Nano-SDF Scaffold as a Cell-Free-Based Treatment Strategy Improve Traumatic Brain Injury Mechanisms by Decreasing Oxidative Stress, Neuroinflammation, and Increasing Neurogenesis

Cited by 14 publications

References 60 publications

Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade

Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade

Biomaterial‐Facilitated Local Delivery of Stem Cell‐Derived Small Extracellular Vesicles: Perspectives in Surgical Therapy

Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

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