Exosomes derived from exhausted CD8+ T cells impaired the anticancer function of normal CD8+ T cells

Wang, X; Shen, Haiyuan; He, Qifeng; Tian, Wen‐de; Xia, Anliang; Lu, Xiao‐Jie

doi:10.1136/jmedgenet-2018-105439

Cited by 65 publications

(56 citation statements)

References 10 publications

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“…Meanwhile, the exhausted CD8 + T cells, which express TIM-3 and PD-1 during the antitumor immune responses, exhibit reduced proliferation and impaired anticancer activities. The regular CD8 + T cells uptake exosomes containing lncRNAs secreted by the exhausted CD8 + T cells, which leads to CD8 + T cell dysfunction (41). Furthermore, some lncRNAs expressed in the tumor cells are affected by immune cells.…”

Section: Features and Functional Modules Of Lncrnas In Tumor Immune Rmentioning

confidence: 99%

Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment

Luo

Yang

et al. 2020

Front. Oncol.

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Section: Features and Functional Modules Of Lncrnas In Tumor Immune Rmentioning

confidence: 99%

Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment

Luo

Yang

et al. 2020

Front. Oncol.

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“…TEx from head and neck cancers induce a CD27 ‐ /CD28 ‐ suppressive phenotype in CD8 T cells . Interestingly, other suppressive CD8 T cell populations are induced by hepatocellular carcinomas and prostate tumours, including exhausted (PD1 + /TIM3 + ) and inhibitory (CTLA4 + ) cells which contribute to the suppressive tumour microenvironment by exosome/IL‐35 production . Thus, atypical suppressive CD8 T cell populations contribute to tumour immune escape by secretion of immunoregulatory exosomes.…”

Section: Exosomes In Tumour Immune Evasionmentioning

confidence: 99%

Role of exosomes in tumour and transplant immune regulation

Lema

Burlingham

2019

Scand J Immunol

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Exosomes are a potent means for intercellular communication. However, exosomes have received intensive research focus in immunobiology only relatively recently.Because they transport proteins, lipids and genetic material between cells, they are especially suited to amplify their parental cell's message and overcome the physical constraints of cell-to-cell contact, that is exosome release gives cells the ability to alter distant, non-contiguous cells. As progress is made in this field, it has become increasingly obvious that exosomes are involved in most biological processes. In the immune system, exosomes are fundamental tools used by every immune cell type to fulfil its function and promote inflammation or tolerance. In this review, we first summarize key aspects of immune cell-specific exosomes and their functions. Then, we describe how exosomes have been shown to be indispensable orchestrators of the immune response in two immunological scenarios, namely transplant rejection or tolerance, and tumour evasion or initiation of anti-tumour immune responses.

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“…IFN-γ and IL-2, and thus attenuating the anticancer effect of normal CD8 + T cells (Fig. 7 b) [ 172 ]. Importantly, they identified 257 candidate lncRNAs with different expression in exosomes of both.…”

Section: Introductionmentioning

confidence: 99%

“…Importantly, they identified 257 candidate lncRNAs with different expression in exosomes of both. These lncRNAs actively implicated in tuning various biological processes of CD8 + T cell activity [ 172 ].…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA: a dazzling dancer in tumor immune microenvironment

Zhang

Liu

Liao

2020

J Exp Clin Cancer Res

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Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. Emerging evidence indicates that lncRNAs participate in crosstalk between tumor and stroma, and reprogramming of tumor immune microenvironment (TIME). TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. However, hitherto, a comprehensive review aiming at relationship between lncRNAs and TIME is missing. In this review, we focus on the functional roles and molecular mechanisms of lncRNAs within the TIME. Furthermore, we discussed the potential immunotherapeutic strategies based on lncRNAs and their limitations.

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Exosomes derived from exhausted CD8+ T cells impaired the anticancer function of normal CD8+ T cells

Cited by 65 publications

References 10 publications

Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment

Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment

Role of exosomes in tumour and transplant immune regulation

Long noncoding RNA: a dazzling dancer in tumor immune microenvironment

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