Exosomes Protect Against Acute Myocardial Infarction in Rats by Regulating the Renin-Angiotensin System

Xiao, Mengyuan; Zeng, Weikai; Wang, Junxian; Feng, Yao; Peng, Zijian; Liu, Guangyan; Yu, Liqin; Wei, Wenyan; Zhou, Shengfeng; Li, Kaize; Wu, Luyao; Zhu, Kunpeng; Guan, Yuejie; Chen, Huanyu; Liu, Zhenjun; Chen, Jianying

doi:10.1089/scd.2020.0132

Cited by 16 publications

(12 citation statements)

References 32 publications

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“…Renin-angiotensin system plays an important role in the mediation of AMI [ 29 ]. Exosomes prevent AMI in rats by modulating the renin-angiotensin system [ 30 ]. Therefore, we speculate that ANPEP may play an important role in the ongoing case mechanism of AMI by regulating metabolic pathways, glutathione metabolism, hematopoietic cell lineage, and renin-angiotensin system with other mRNAs.…”

Section: Discussionmentioning

confidence: 99%

Uncovering potential diagnostic biomarkers of acute myocardial infarction based on machine learning and analyzing its relationship with immune cells

Kang

Zhao

Jiang

et al. 2023

BMC Cardiovasc Disord

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Background Acute myocardial infarction (AMI) is a common cardiovascular disease. This study aimed to mine biomarkers associated with AMI to aid in clinical diagnosis and management. Methods All mRNA and miRNA data were downloaded from public database. Differentially expressed mRNAs (DEmRNAs) and differentially expressed miRNAs (DEmiRNAs) were identified using the metaMA and limma packages, respectively. Functional analysis of the DEmRNAs was performed. In order to explore the relationship between miRNA and mRNA, we construct miRNA-mRNA negative regulatory network. Potential biomarkers were identified based on machine learning. Subsequently, ROC and immune correlation analysis were performed on the identified key DEmRNA biomarkers. Results According to the false discovery rate < 0.05, 92 DEmRNAs and 272 DEmiRNAs were identified. GSEA analysis found that kegg_peroxisome was up-regulated in AMI and kegg_steroid_hormone_biosynthesis was down-regulated in AMI compared to normal controls. 5 key DEmRNA biomarkers were identified based on machine learning, and classification diagnostic models were constructed. The random forests (RF) model has the highest accuracy. This indicates that RF model has high diagnostic value and may contribute to the early diagnosis of AMI. ROC analysis found that the area under curve of 5 key DEmRNA biomarkers were all greater than 0.7. Pearson correlation analysis showed that 5 key DEmRNA biomarkers were correlated with most of the differential infiltrating immune cells. Conclusion The identification of new molecular biomarkers provides potential research directions for exploring the molecular mechanism of AMI. Furthermore, it is important to explore new diagnostic genetic biomarkers for the diagnosis and treatment of AMI.

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Section: Discussionmentioning

confidence: 99%

Uncovering potential diagnostic biomarkers of acute myocardial infarction based on machine learning and analyzing its relationship with immune cells

Kang

Zhao

Jiang

et al. 2023

BMC Cardiovasc Disord

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“…Recently, bone marrow mesenchymal stem cell-derived exosomes (BMSC-EX) was found to form sustained myocardial protection against acute MI partly through accelerating the conversion of AngII to Ang-(1-7) [ 53 ]. Olmesartan [ 30 ] has also been reported to attenuate myocardial remodeling via activating ACE2-Ang-(1-7)-MasR axis [ 54 ], suggesting new strategy utilizing ACE2-Ang-(1-7)-MasR axis as a promising pharmacological target in MI.…”

Section: Discussionmentioning

confidence: 99%

Alamandine alleviated heart failure and fibrosis in myocardial infarction mice

Zhao

Mao

et al. 2022

Biol Direct

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Alamandine (Ala) is the newest identified peptide of the renin-angiotensin system and has protective effect on myocyte hypertrophy. However, it is still unclear whether Ala can alleviate heart failure (HF). The aim of this study was to explore the effects of Ala on HF and the related cardiac fibrosis, and to probe the mechanism. HF model was induced by myocardial infarction (MI) in mice. Four weeks after MI, Ala was administrated by intraperitoneal injection for two weeks. Ala injection significantly improved cardiac dysfunction of MI mice in vivo. The cardiac fibrosis and the related biomarkers were attenuated after Ala administration in HF mice in vivo. The increases of collagen I, alpha-smooth muscle actin and transforming growth factor-beta induced by oxygen–glucose deprivation (OGD) in neonatal rat cardiac fibroblasts (NRCFs) were inhibited by Ala treatment in vitro. The biomarkers of apoptosis were elevated in NRCFs induced by OGD, which were attenuated after treating with Ala in vitro. The enhancement of oxidative stress in the heart of MI mice or in the NRCFs treated with OGD was suppressed by treating with Ala in vivo and in vitro. These effects of Ala were reversed by tBHP, an exogenous inducer of oxidative stress in vitro. These results demonstrated that Ala could alleviate cardiac dysfunction and attenuate cardiac fibrosis via inhibition of oxidative stress.

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“…The characteristics and molecular mechanisms of all the related studies mentioned above are shown in Table 1 (Ref. [31][32][33][34][35][36][40][41][42][43][44][45][46][47]54,55,61,64,71,72]).…”

Section: Msc-exo Participates In Cardiac Remodeling By Mediating Fibr...mentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosomes in Cardioprotection: A Novel Application to Prevent Myocardial Injury

Yang¹,

Li²,

Tang³

et al. 2022

Rev. Cardiovasc. Med.

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Perioperative myocardial injury is a common complication caused by major surgery. Many pharmacological and nonpharmacological studies have investigated perioperative cardioprotection. However, the methods are insufficient to meet the increasing clinical needs for cardioprotection. The application of Mesenchymal Stem Cell-Derived Exosomes (MSC-Exos) is a novel cell-free therapeutic strategy and has significantly benefitted patients suffering from various diseases. In this review, we comprehensively analyzed the application of MSC-Exos to prevent myocardial infarction/injury by regulating inflammatory reactions, inhibiting cardiomyocyte apoptosis and autophagy, promoting angiogenesis, and mediating cardiac remodeling. Finally, we assessed the therapeutic effects and the challenges associated with the application of MSC-Exos from a clinical perspective.

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Exosomes Protect Against Acute Myocardial Infarction in Rats by Regulating the Renin-Angiotensin System

Cited by 16 publications

References 32 publications

Uncovering potential diagnostic biomarkers of acute myocardial infarction based on machine learning and analyzing its relationship with immune cells

Uncovering potential diagnostic biomarkers of acute myocardial infarction based on machine learning and analyzing its relationship with immune cells

Alamandine alleviated heart failure and fibrosis in myocardial infarction mice

Mesenchymal Stem Cell-Derived Exosomes in Cardioprotection: A Novel Application to Prevent Myocardial Injury

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