Experience with Creutzfeldt-Jakob disease in a single referral center in Mexico. Case series

Cárdenas-Saenz, Omar; Quiñones-Pesqueira, Gerardo; Marcín-Sierra, Mariana; Cervantes-Arriaga, Amin; Rodríguez-Violante, Mayela; Kerik-Rotenberg, Nora E.; Díaz-Meneses, Iván E.; Perez‐Lohman, Christian; Bazán-Rodríguez, Lisette

doi:10.24875/gmm.m22000719

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the countries of Middle and South America, some such as Argentina, Chile, Mexico, Brazil, and Peru have reported their data of PrD surveillance or studies. For example, in Argentina, 211 cases have been reported from 1996 to 2007; in Chile, 230 cases from 2001 to 2007 ( 45 ); in Mexico, 29 cases from seven individual studies from 1990 to 2020 ( 46 ) and 24 cases in a referral center during 2014–2019 ( 47 ); in Brazil, 35 cases during the period 2005–2007 ( 48 ), 408 sCJD cases, and several gCJD cases during the period 2005–2020 ( 48 ); and in Peru, 11 and six sCJD cases and several gCJD cases from various literatures ( 49 , 50 ). It is apparent that the PrD or CJD case numbers globally are markedly undervalued, which may pose a potential biosafety risk.…”

Section: Discussionmentioning

confidence: 99%

Updated global epidemiology atlas of human prion diseases

Gao,

Tian,

Xiao

et al. 2024

Front. Public Health

View full text Add to dashboard Cite

IntroductionHuman prion disease (PrD), a group of fatal and transmissible neurodegenerative diseases, consists of Creutzfeldt–Jakob disease (CJD), kuru, fatal familial insomnia (FFI), Gerstmann-Sträussler-Scheinker disease (GSS), and variably protease-sensitive prionopathy (VPSPr). The emergence of bovine spongiform encephalopathy (BSE) in cattle and variant CJD (vCJD) has greatly threatened public health, both in humans and animals. Since the 1990's, dozens of countries and territories have conducted PrD surveillance programs.MethodsIn this study, the case numbers and alternative trends of different types of PrD globally and in various countries or territories from 1993 to 2020 were collected and analyzed based on the data from the websites of the international and national PrD surveillance programs, as well as from relevant publications.ResultsThe total numbers of the reported PrD and sporadic CJD (sCJD) cases in 34 countries with accessible annual case numbers were 27,872 and 24,623, respectively. The top seven countries in PrD cases were the USA (n = 5,156), France (n = 3,276), Germany (n = 3,212), Italy (n = 2,995), China (n = 2,662), the UK (n = 2,521), Spain (n = 1,657), and Canada (n = 1,311). The annual PrD case numbers and mortalities, either globally or in the countries, showed an increased trend in the past 27 years. Genetic PrD cases accounted for 10.83% of all reported PrD cases; however, the trend varied largely among the different countries and territories. There have been 485 iatrogenic CJD (iCJD) cases and 232 vCJD cases reported worldwide.DiscussionThe majority of the countries with PrD surveillance programs were high- and upper-middle-income countries. However, most low- and lower-middle-income countries in the world did not conduct PrD surveillance or even report PrD cases, indicating that the number of human PrD cases worldwide is markedly undervalued. Active international PrD surveillance for both humans and animals is still vital to eliminate the threat of prion disease from a public health perspective.

show abstract