Experimental and Clinical Studies of Mechanisms of the Antiaging Effects of Chemical Compounds in Astragalus membranaceus (Review)

Berezutsky, M. A.; Дурнова, Н. А.; Vlasova, I A

doi:10.1134/s2079057020020046

Cited by 14 publications

(3 citation statements)

References 43 publications

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“…Nevertheless, a recent animal study indicated that physical exercise can increase POT1 While telomerase enzymes protect against telomere shortening, and cells with more telomerases have longer telomeres, the short-term use of cooked brassica leafy vegetables could increase telomerase activity in CD8+ lymphocytes in humans [103]. Moreover, there is evidence that the chemical compounds of Astragalus membranaceus activate telomerase, inhibit senescence, and have neuroprotective effects [104]. Eucalyptus camaldulensis bark extract increases telomerase expression, exhibiting anti-aging, anti-apoptosis, and anti-senescence effects as well [105].…”

Section: Telomere Attrition and Aging And The Effects Of Phytochemicalsmentioning

confidence: 99%

Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic Strategies Using Phytochemicals

Abdolmaleky

Zhou

2023

Nutrients

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During aging, several tissues and biological systems undergo a progressive decline in function, leading to age-associated diseases such as neurodegenerative, inflammatory, metabolic, and cardiovascular diseases and cancer. In this review, we focus on the molecular underpinning of senescence and neurodegeneration related to age-associated brain diseases, in particular, Alzheimer’s and Parkinson’s diseases, along with introducing nutrients or phytochemicals that modulate age-associated molecular dysfunctions, potentially offering preventive or therapeutic benefits. Based on current knowledge, the dysregulation of microglia genes and neuroinflammation, telomere attrition, neuronal stem cell degradation, vascular system dysfunction, reactive oxygen species, loss of chromosome X inactivation in females, and gut microbiome dysbiosis have been seen to play pivotal roles in neurodegeneration in an interactive manner. There are several phytochemicals (e.g., curcumin, EGCG, fucoidan, galangin, astin C, apigenin, resveratrol, phytic acid, acacetin, daucosterol, silibinin, sulforaphane, withaferin A, and betulinic acid) that modulate the dysfunction of one or several key genes (e.g., TREM2, C3, C3aR1, TNFA, NF-kb, TGFB1&2, SIRT1&6, HMGB1, and STING) affected in the aged brain. Although phytochemicals have shown promise in slowing down the progression of age-related brain diseases, more studies to identify their efficacy, alone or in combinations, in preclinical systems can help to design novel nutritional strategies for the management of neurodegenerative diseases in humans.

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Section: Telomere Attrition and Aging And The Effects Of Phytochemicalsmentioning

confidence: 99%

Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic Strategies Using Phytochemicals

Abdolmaleky

Zhou

2023

Nutrients

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“…The evaluation of phytochemical composition can be considered as the first step for the determination of the beneficial health properties of a plant, as it permits a preliminary approach on the assessment of chemical compound structure-related activities (Souto et al 2019). Figure 7 shows the potential beneficial effects of this plant, e.g., neuroprotection (Chan et al 2009), renoprotection (Yin et al 2004;Wen et al 2020), hepatoprotection (Ali et al 2018), hypoglycemic (Kai et al 2015), anti-osteoporosis (Koo et al 2013), anti-fatigue (Berezutsky et al 2019), antiinflammatory (He et al 2012), immune system boosting (Lee et al 2003), anti-cancer , antioxidant (Lee et al 2011), and cardioprotection (Zhang et al 2006).…”

Section: In Vitro and In Vivo Therapeutic Potentials Of Astragalus (Astragalus Membranaceus): An Update Shotmentioning

confidence: 99%

Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role

Durazzo

Nazhand

Lucarini

et al. 2021

Rend. Fis. Acc. Lincei

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Medicinal plants always are part of folk medicine and are nowadays receiving worldwide attention for prophylaxis, management, and treatment of several diseases, as an alternative to chemical drugs. The current work provided a comprehensive overview and analysis of the Astragalus and health relationship in literature. The analysis of their therapeutic potential is thus instrumental to understand their bioactivity. Among these, the flowering medicinal plant Astragalus membranaceus has raised interest due to several beneficial health effects. This perspective review discussed the botanical, geographical, historical, and the therapeutic properties of A. membranaceus, with a special focus on its health improving effects and medicinal applications both in vitro and in vivo. Graphic abstract

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“…Astragali Radix (AR), a common traditional Chinese herbal medicine used in China for over 2,000 years, is also extensively used in numerous countries and has been included in the pharmacopeias of the United States, Japan, and South Korea ( 15 ). Medical research shows that AR exhibits various therapeutic activities, including anti-tumor ( 16 – 19 ), anti-aging ( 20 ), immune regulatory ( 21 ), anti-fibrosis ( 22 ), antibacterial ( 23 ), antiviral ( 24 , 25 ), and anti-radiation ( 26 ) effects. Astragalus polysaccharide (APS), a major active component of AR ( 27 – 30 ), is extensively used in medicine as it demonstrates beneficial activities and low toxicity ( 31 ).…”

Section: Introductionmentioning

confidence: 99%

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

Yang,

Meng,

Zhang

et al. 2024

Front. Oncol.

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The dry root of the soybean plant Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao or A. membranaceus (Fisch) Bge, Astragali Radix (AR) has a long medicinal history. Astragalus polysaccharide (APS), the natural macromolecule that exhibits immune regulatory, anti-inflammatory, anti-tumor, and other pharmacological activities, is an important active ingredient extracted from AR. Recently, APS has been increasingly used in cancer therapy owing to its anti-tumor ability as it prevents the progression of prostate, liver, cervical, ovarian, and non-small-cell lung cancer by suppressing tumor cell growth and invasion and enhancing apoptosis. In addition, APS enhances the sensitivity of tumors to antineoplastic agents and improves the body’s immunity. This macromolecule has prospects for broad application in tumor therapy through various pathways. In this article, we present the latest progress in the research on the anti-tumor effects of APS and its underlying mechanisms, aiming to provide novel theoretical support and reference for its use in cancer therapy.

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Experimental and Clinical Studies of Mechanisms of the Antiaging Effects of Chemical Compounds in Astragalus membranaceus (Review)

Cited by 14 publications

References 43 publications

Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic Strategies Using Phytochemicals

Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic Strategies Using Phytochemicals

Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

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