Experimental Caries and Gingival Pathologic Changes in the Gnotobiotic Rat

Fitzgerald, Robert J.; Jordan, H.V.; Stanley, Harold R.; Poole, W.L.; Bowler, Ann E.

doi:10.1177/00220345600390052701

Cited by 219 publications

(69 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In recent years, this organism has become the subject of considerable investigation since its caries-inducing potential was demonstrated in animal models (FITZGERALD, JORDAN and STANLEY, 1960;FITZGERALD and KEYES, 1960). Studies which are concerned with elucidating the aetiologic role of Strep.…”

Section: Introductionmentioning

confidence: 99%

A selective medium for Streptococcus mutans

Gold¹,

Jordan²,

Houte³

1973

Archives of Oral Biology

Self Cite

873

497

View full text Add to dashboard Cite

Summary-A selective medium was developed for the isolation of Streptococcus mutans from human dental plaque. Mitis-salivarius agar was modified by adding 0.2 units/ml bacitracin and by increasing the sucrose concentration to 20 per cent. At these concentrations, the selective agents allowed the undiminished recovery of Strep. mutans with maximum inhibition of the balance of the streptococcal flora normally encountered on this medium. Enterococci or yeasts were sometimes observed upon direct culturing of plaque samples from children with advanced dentinal lesions.

show abstract

Section: Introductionmentioning

confidence: 99%

A selective medium for Streptococcus mutans

Gold¹,

Jordan²,

Houte³

1973

Archives of Oral Biology

Self Cite

873

497

View full text Add to dashboard Cite

show abstract

“…There exists a strong association between the accumulation of dental plaque, a dense adhesive mass of microbial cells, and the occurrence of dental caries and gingivitis/periodontitis (5,10,11,21,22,(26)(27)(28)(29). It is possible to prevent dental plaques associated with gingivitis and caries by repeated local applications of antimicrobial agents (15,32,33).…”

mentioning

confidence: 99%

Structural Requirements of Guanide, Biguanide, and Bisbiguanide Agents for Antiplaque Activity

Tanzer

Slee

Kamay

1977

Antimicrob Agents Chemother

View full text Add to dashboard Cite

The bactericidal efficacy of 16 guanide, biguanide, and bisbiguanide agents was studied in vitro against intact preformed plaques of four oral (plaqueforming) microorganisms: Streptococcus mutans, S. sanguis, Actinomyces viscosus, and A. naeslundii. The activities of these agents were examined in relation to their molecular configurations. These studies indicated that the bisand biguanide configurations are important for efficacy, as is the length of the alkyl side chain. No structural moiety determined efficacy by itself. Furthermore, the activities of these agents were studied to determine the minimal conditions (concentration, duration, and frequency) of treatment required for likely clinical efficacy. At least six agents were judged to have equal or greater efficacy than the reference agent, chlorhexidine digluconate. A plaque bactericidal index was derived for the most potent agents, and comparison to the bactericidal properties of chlorhexidine was expressed as a chlorhexidine coefficient.

show abstract

“…Dental plaque, the dense adhesive microbial mass that colonizes the teeth, is strongly implicated in both experimental animals and humans as the key etiological factor in dental caries (6,10,11,19,20,28,38) and periodontal disease (17,25,30,41). Notable among those microorganisms associated with dental plaque accumulation are strains ofActinomyces viscosus, Actinomyces naeslundii (2, 12,21,22,26,40), Streptococcus mutans (13,14,42), and Streptococcus sanguis (4,6).…”

mentioning

confidence: 99%

In Vitro Evaluation of Three Iodine-Containing Compounds as Antiplaque Agents

Tanzer

Slee

Kamay

et al. 1977

Antimicrob Agents Chemother

View full text Add to dashboard Cite

The antibacterial activity of three iodine-containing compounds was determined for strains of four dental plaque-forming microorganisms, using an in vitro preclinical plaque model system. Solutions of inorganic iodine, povidone-iodine, and Wescodyne were tested for antiplaque activity against preformed plaques of a number of strains of Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus , and Actinomyces naeslundii . Solutions of inorganic iodine were more effective as antiplaque agents, with respect to minimal bactericidal concentration and time and frequency of treatments, than solutions of Wescodyne and povidone-iodine. Inorganic iodine appeared to be particularly effective against the most cariogenic ( S. mutans ) and periodontopathic ( A. viscosus ) organisms while allowing survival of the least orally pathogenic plaque-forming microorganism ( S. sanguis ). It is suggested that topical application of solutions of inorganic iodine may be useful in controlling dental caries and actinomyces-associated periodontal disease.

show abstract

Experimental Caries and Gingival Pathologic Changes in the Gnotobiotic Rat

Cited by 219 publications

References 5 publications

A selective medium for Streptococcus mutans

A selective medium for Streptococcus mutans

Structural Requirements of Guanide, Biguanide, and Bisbiguanide Agents for Antiplaque Activity

In Vitro Evaluation of Three Iodine-Containing Compounds as Antiplaque Agents

Contact Info

Product

Resources

About