Experimental Comparison of Photothermal Conversion Efficiency of Gold Nanotriangle and Nanorod in Laser Induced Thermal Therapy

Abstract

An experimental comparison of the photothermal conversion efficiency (PCE) for gold nanotriangles (GNTs) and nanorods (GNRs) was carried out in the present work. The discrete dipole approximation method was applied to identify the spectral characteristic of GNTs and GNRs with different aspect ratios. On this basis, the PCE of GNTs and GNRs in photothermal therapy were compared theoretically. Afterwards, an in vitro experiment was adopted to investigate the thermal effect of porcine muscle induced by laser irradiation, with and without injected GNTs and GNRs. The influences of laser total power, nanoparticle concentration, and nanoparticle type were investigated. It was found that for the commonly-used wavelengths for photothermal therapy, the PCE of GNTs is higher than that of the GNRs. Furthermore, for GNRs loaded in tissue in vitro, high laser power and high concentration of nanoparticles leads to the degeneration and even carbonization of tissue. However, for the GNTs with the same situation (laser power, nanoparticle volume concentration, and heating time), it could lead to the tissue’s evaporation instead of carbonization.

Ag@TiO2 Nanoprisms with Highly Efficient Near‐Infrared Photothermal Conversion for Melanoma Therapy

“…For example,t he temperatures are 57.3, 62.1 and 65.5 8Cfor the concentration of Ag@TiO 2 of 50, 100 and 150 mgmL À1 .The temperature of the Ag@TiO 2 NPs solution with 200 mgmL À1 changes from 21.0 to 67.7 8Cu nder irradiation for 360 s. Excessive body temperature, that is, heating of whole or local body tissues, has been used to kill cancer cellsd irectly at temperatures above 42 degrees Celsius. [23] The photothermal conversion efficiency (h)o fA g@TiO 2 NPs was calculatedb yf ollows equation…”

Ablation of Red Stable Transfected Prostate Cancer Cell Lines by C-CPE Gold-Nanoparticle Mediated Laser Intervention

“…In recent years, laser therapy using gold nanoparticles (AuNPs) has rapidly evolved as a non-invasive thermotherapy for cancer as it enables hyperthermia of tumor tissues [27][28][29][30][31]. During laser treatment, AuNPs are delivered into tumors and are irradiated with laser light.…”

Synthesis and Stabilization of Support-Free Mesoporous Gold Nanoparticles

“…Porous noble metal nanoparticles and thin layers are highly attractive for applications in catalysis, sensing, plasmonics, biochemistry, medical diagnosis, and therapy owing to their unique chemical and optical characteristics. [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Not only the high surface/volume ratios but also the advantageous optical properties of the porous gold nanoparticles (PGNs) are attractive and interesting.…”

“…Support-free porous noble metal nanoparticles can conveniently be administered and tracked in biological systems. These properties together with their porosities and optical characteristics form the basis of their biomedical applications, such as drug delivery [ 18 , 19 ], drug-screening [ 20 ], drug encapsulation [ 21 , 22 ], gene delivery [ 23 , 24 , 25 ], photothermal therapy [ 6 , 7 , 8 , 9 , 10 ], diagnostic imaging [ 26 ] and ophthalmological applications [ 27 ]. Furthermore, the biocompatibility of gold nanoparticles has also been confirmed by numerous cytotoxicity studies [ 28 , 29 ].…”