Experimental Development of New Surgical Suturing Materials with Complex Biological Activities

Mokhov, Evgeny Mikhailovich; Homullo, G. V.; Сергеев, А.Н.; Alexandrov, Ilya

doi:10.1007/s10517-012-1728-2

Cited by 3 publications

(4 citation statements)

References 3 publications

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“…По результатам приведенных исследований можно предложить следующий режим прививки МАК к ПКА [16,17]: концентрация мономера 15%, температура 60 °C; продолжительность обработки 60 мин; pH раствора -4,5; концентрация Fe 2+ -0,05%; концентрация Н 2 О 2 -0,1%; МВ -100. В данных условиях СОЕ нити достигает значений 2,1-2,3 ммоль/г.…”

Section: результаты и обсуждениеunclassified

“…С этой целью привитую сополимеризацию МАК к ПКА нитям инициировали пероксидными и гидропероксидными группами, которые предварительно вводили в полимер окислением системой Fe 3+ +Н 2 О 2 (рисунок 2). Преимуществом данного метода, с одной стороны, является существенное уменьшение вероятности образования гомополимера, а с другой -сохранение физико-механических свойств нитей [13,16]. Рисунок 2.…”

Section: результаты и обсуждениеunclassified

“…достаточно быстро колонизируются микрофлорой, образующей на поверхности изделия биопленку, защищающую их от воздействия как факторов иммунной защиты организма, так и антимикробных препаратов. С учетом этой ситуации целесообразно воздействие на микроорганизмы изнутри, т. е. непосредственно с поверхности имплантата, содержащего соответствующие лекарственные препараты, что позволяет снизить их концентрацию в организме и локализовать воздействие [1][2][3][4][5][6][7][8].…”

Section: Introductionunclassified

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Imparting ion-exchange properties to fibrous polycaproamide materials by chemically initiated graft copolymerization

Zhukovskiy

Khokhlova

Filipenko

et al. 2022

Vestn. Voronež. gos. univ. inž. tehnol.

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The study of the types and properties of surgical threads, as well as the experience in the production of suture surgical material and its use shows that the most promising for surgical practice are threads with antimicrobial properties. Of the methods for fixing medicinal compounds with chemical bonds for suture materials, the most expedient is their attachment by the reaction of ion-exchange interaction. Since polycaproamide (PCA) practically does not contain functional groups, a preliminary modification stage is required to impart ion-exchange properties to PCA fibrous materials. One of these stages of modification is the process of graft polymerization of methacrylic acid (MAA) in order to create active groups on the fiber, for example, peroxide or hydroperoxide. Modification of chemical fibers by graft copolymerization with inogenic monomers is one of the widespread methods of obtaining fibrous ion exchangers. Principles, new approaches and technologies for imparting ion-exchange properties to fibrous polycaproamide materials by chemically initiated graft copolymerization have been developed. Regularities in the production of fibrous PCA of sorption active materials by chemical initiation by a redox system (Fe2++H2O2) located in a modifying bath, as well as by pre-oxidation of fiber PCA in order to create peroxide and hydroperoxide groups on the fiber, are revealed.

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Section: результаты и обсуждениеunclassified

Section: Introductionunclassified

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Imparting ion-exchange properties to fibrous polycaproamide materials by chemically initiated graft copolymerization

Zhukovskiy

Khokhlova

Filipenko

et al. 2022

Vestn. Voronež. gos. univ. inž. tehnol.

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“…Процент развития послеоперационных раневых осложнений остается высоким [7,8,9,10,11,12,13]. Одним из таких последствий является несостоятельность шва, зависящая, в том числе и от материала, использованного при наложении [13].…”

Section: обзор литературыunclassified

The Opportunities for developing a new biologically active suture material in surgery (literature review)

Морозов

Михайлович²,

Mokhov

et al. 2019

VECS

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The main method of joining the wound edges in surgery remains suturing with the help of threads. Unfortunately, suture materials used in surgery have a number of disadvantages. The percentage of postoperative wound complications remains high. One of these consequences is the failure of the seam, depending also on the material used in the operation. Suture material, as a genetically alien object, that is a foreign body, with a long stay in the tissues can lead to the development of complications: causes suppuration of wounds, formation of abscesses, peritonitis. Materials and methods: The analysis of modern Russian-language and foreign literature, also Internet sources devoted to the issue of issues and modern developments of antiseptic suture material. As a result, the choice and development of an ideal suture material that meets all the requirements, remains an unsolved and socially significant problem in surgery. Despite the variety of variations already offered, there is currently no suture material with antimicrobial activity on the market that would fully reduce the risk of developing infections in the surgical area. But the achievements of modern chemical production make it possible to develop biologically active suture materials that have the ability to resist the development of infectious complications in a wound and improve tissue regeneration without adversely affecting the body. In addition, the analysis showed an increased interest of developers to chitosan, due to its exceptional biocompatibility, bioresorbability, non-toxicity, antibacterial properties and hemostaticity.

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Methods of local antimicrobic prophylaxis of surgical site infection

et al. 2020

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Recently, to prevent of surgical site infection, new methods of local antimicrobic prophylaxis have been developed and successfully introduced, which allow to creating high concentrations of antimicrobial drugs in operated tissues and preventing the migration of bacterial flora into the wound. The review describes the main methods used for local impact on microflora and aimed at prophylaxis of surgical site infection. The latter include pre-, intra- and postoperative measures. Optimizing of preoperational methods could be achieved by improving the methods of processing of operating field. Reviews considerable attention is paid to intraoperative measures: the use of surgical gloves with antimicrobial properties, reticulated to implants with antimicrobial properties for tension-free hernioplasty, stage-by-stage surgical wound irrigation with antibacterial drugs during suturing as well as the prospects for the use of bacteriophages in abdominal surgery. To increase the biological tightness of the intestinal suture, some authors propose the use of a biodegradable antibiotic-impregnated implant. The review reflects the possibilities of using biologically active (antimicrobial) sutures, the use of which was very effective at all stages of the operation: from the application of intestinal anastomosis to the skin suture. A wide range of antimicrobial surgical sutures containing antibacterial preparations and made by threads with different biodegradation abilities make, allow us to recommend a differentiated approach to the choice of suture material depending on the stage of surgery and regenerative properties of the sutured tissues. The main measures recommended in the early postoperative period are to cover the wound with special wound coatings preventing the possible contamination and to improve irrigation-aspiration drainage techniques of postoperative wounds.

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Experimental Development of New Surgical Suturing Materials with Complex Biological Activities

Cited by 3 publications

References 3 publications

Imparting ion-exchange properties to fibrous polycaproamide materials by chemically initiated graft copolymerization

Imparting ion-exchange properties to fibrous polycaproamide materials by chemically initiated graft copolymerization

The Opportunities for developing a new biologically active suture material in surgery (literature review)

Methods of local antimicrobic prophylaxis of surgical site infection

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