Experimental Evaluation of Cellulose Acetate NF and Ethylene-Vinyl Alcohol Copolymer for Selective Arterial Embolization

Wright, Kenneth C.; Greff, R. J.; Price, Roger E.

doi:10.1016/s1051-0443(99)70221-6

Cited by 25 publications

(15 citation statements)

References 13 publications

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“…Cellulose derivatives have been explored previously as liquid embolics and in the creation of embolic microspheres in part due to their high degree of biocompatibility and biodegradability [158–161]. Whereas previous cellulose based liquid embolics involved the precipitation of cellulose acetate from DMSO similar to Onyx ® , the Golzarian group combined oxidized carboxymethyl cellulose (OCMC) and carboxymethyl chitosan (CCN) to form a chemically crosslinking injectable hydrogel [115,162].…”

Section: Research and Development Of Advanced Materialsmentioning

confidence: 99%

Polymeric materials for embolic and chemoembolic applications

Poursaid

Jensen

Huo

et al. 2016

Journal of Controlled Release

117

103

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Percutaneous transcatheter embolization procedures involve the selective occlusion of blood vessels. Occlusive agents, referred to as embolics, vary in material characteristics including chemical composition, mechanical properties, and the ability to concurrently deliver drugs. Commercially available polymeric embolics range from gelatin foam to synthetic polymers such as poly(vinyl alcohol). Current systems under investigation include tunable, bioresorbable microspheres composed of chitosan or poly(ethylene glycol) derivatives, in situ gelling liquid embolics with improved safety profiles, and radiopaque embolics that are trackable in vivo. This article reviews commercially available materials used for embolization as well as polymeric materials that are under investigation.

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Section: Research and Development Of Advanced Materialsmentioning

confidence: 99%

Polymeric materials for embolic and chemoembolic applications

Poursaid

Jensen

Huo

et al. 2016

Journal of Controlled Release

117

103

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“…Current endovascular embolizations use materials such as cyanoacrylate, polyvinyl alcohol (PVA), hyaluronic acid gels, and cellulose acetate to treat vascular defects such as AVMs and aneurysms. [1][2][3][4] Some endovascular polymer "glues" adhere to the vessel by damaging and infiltrating the vessel wall, increasing the likelihood of hemorrhage. 5 Other polymer glues are difficult to control during endovascular injection.…”

Section: Introductionmentioning

confidence: 99%

Calcium alginate gel: A biocompatible and mechanically stable polymer for endovascular embolization

Becker

Kipke

Brandon

2000

J. Biomed. Mater. Res.

212

148

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The development and optimization of calcium alginate for potential use in endovascular occlusion was investigated by testing its in vitro and in vivo mechanical stability and biocompatibility. The compressive resistance, rheology, and polymer yield of reacted alginate, and the polymer viscosity of unreacted alginate, were assessed. Biocompatibility was tested by injecting calcium alginate into the kidney capsule of rats. The reactivity of alginates with various structures and levels of purity were compared visually and histologically. Results suggest that calcium alginate is a biocompatible and mechanically stable gel for endovascular applications. Purified alginates exhibited compressive strength of 22 kPa and above at 40% compression, with no significant loss in elasticity. Purified alginate strength was significantly higher than that of crude alginates (p < 0.08). Purified alginates also exhibited significantly lower tissue reaction than crude alginates (p < 0.05). Of the alginates tested, purified high guluronic acid alginates (PHG) exhibited optimal strength and polymer yield, increased biocompatibility, and decreased viscosity. Clinical embolization treatments may be improved with the development of stable and biocompatible polymers such as calcium alginate. Possible uses of improved endovascular polymers include treating arteriovenous malformations (AVMs), aneurysms, blood flow to tumors, and vascular hemorrhaging.

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“…Somado a isto, as partí-culas de PVA-flocular são suscetíveis à degradação ao longo do tempo (biodegradabilidade), facilitando a futura recanalização do leito vascular tratado 1,4,[7][8][9] . Com intuito de se contornar as características indesejáveis inerentes às partículas de PVA comercialmente disponíveis, formas diferentes de uso têm sido experimentadas e várias novas substâncias têm sido criadas e testadas 1,4,[8][9][10][11][12][13][14][15] . Derdeyn et al 8 realizaram um estudo com objetivo de avaliar as características da partícula de PVA-flocular e determinar se ela muda de tamanho quando suspensa em meio de contraste não iônico ou quando suspensa em uma solução alternativa de contraste não iônico e álcool absoluto, e concluíram que a partícula de PVA-flocular aumentou significativamente de tamanho nas duas diferentes soluções, uma vez que o PVAflocular é uma espuma de polivinil que se comporta como esponja.…”

Section: Mendes Et Alunclassified

Estudo comparativo da reação inflamatória renal entre álcool de polivinil - flocular e álcool de polivinil + acetato de polivinil - esférico: estudo experimental

Mendes¹,

Chagas

Pinto

et al. 2005

Rev. Col. Bras. Cir.

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; Gaudencio Espinosa,TCBC-RJ 5 RESUMO: Objetivo: Avaliar as características e os efeitos de um agente embólico, disponível comercialmente, consistindo de Polivinil Álcool (PVA) de morfologia flocular, e comparar com um agente esférico, de tecnologia nacional, consistindo de Polivinil Álcool e Polivinil Acetato (PVA + PVAc). Método: Foram utilizadas fêmeas de coelho albino "New Zealand", submetidas à embolização arterial renal. PVA-flocular foi usado em 24 animais, assim como PVA+PVAc-esférico. Seis animais foram utilizados como controle. Todos foram mantidos em cativeiro até a morte, por períodos pós-operatórios de 48 horas, cinco dias, 10 dias e 30 dias. Resultados: Ambos os agentes promoveram oclusão do vaso e infarto do órgão. O estudo microscópico inicial das artérias embolizadas com PVA-flocular, mostra oclusão com trombo e PVA. Os vasos embolizados com PVA+PVAc-esférico, mostram os agentes ocupando praticamente todo o lúmen. No estudo de 30 dias, observa-se absorção do trombo e retração dos agentes de PVAflocular, criando espaços. E com PVA+PVAc-esférico, pode-se observar os agentes circundados por intensa fibrose. Conclusões: Ambas as partículas foram efetivas para causar isquemia tecidual. A reação inflamatória foi mais intensa com PVA+PVAc-esférico que também apresentou grau de penetração maior no sistema vascular (Rev. Col. Bras. Cir. 2005; 32(3): 120-126).

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Experimental Evaluation of Cellulose Acetate NF and Ethylene-Vinyl Alcohol Copolymer for Selective Arterial Embolization

Cited by 25 publications

References 13 publications

Polymeric materials for embolic and chemoembolic applications

Polymeric materials for embolic and chemoembolic applications

Calcium alginate gel: A biocompatible and mechanically stable polymer for endovascular embolization

Estudo comparativo da reação inflamatória renal entre álcool de polivinil - flocular e álcool de polivinil + acetato de polivinil - esférico: estudo experimental

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