2022
DOI: 10.3390/jof8020198
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Experimental Evolution of Multidrug Resistance in Neurospora crassa under Antifungal Azole Stress

Abstract: Multidrug resistance, defined as the resistance to multiple drugs in different categories, has been an increasing serious problem. Limited antifungal drugs and the rapid emergence of antifungal resistance prompt a thorough understanding of how the occurrence of multidrug resistance develops and which mechanisms are involved. In this study, experimental evolution was performed under single-azole-drug stress with the model filamentous fungus Neurospora crassa. By about 30 weeks of continuous growth on agar plate… Show more

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