Experimental Functional Analysis of Self-Expanding Stents Using a New Developed Ex Vivo Model

Grenacher, Lars; Gänger, Ellen; Lubienski, Andreas; Düx, Markus; Kauffmann, G. W.; Richter, G. M.

doi:10.1097/01.rli.0000123315.19579.af

Cited by 7 publications

(3 citation statements)

References 32 publications

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“…Up to now, in vitro models, including mathematical and cadaveric ones, have been designed to evaluate endovascular devices. [4][5][6][7] However, these models lack the vessel viscoelastic properties and biological responses and cannot be used to evaluate the host biological response to implantation of endovascular devices. In vivo models have also been made, 1 and these models are invaluable for assessing new materials or devices before considering a human application, because, compared with ex vivo ones, they own some unique characteristics of pulsatile blood flow and vascular responses, including vasospasm, endothelial injury and neo-intimal formation.…”

Section: Discussionmentioning

confidence: 99%

Construction of an in vivo carotid siphon model for testing endovascular devices for neuro-interventions

et al. 2017

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Objective The aim of this study was to construct an in vivo carotid siphon model for testing neurovascular devices for endovascular interventions. Methods A model of a human carotid siphon was pre-shaped using a glass tube from a human cadaver and used to confine a segment of one side of the common carotid artery (CCA) in canines. This segment of CCA with the glass carotid siphon on was interposed end-to-end onto the contralateral CCA so as to simulate a human carotid artery siphon in vivo. Two weeks later, the siphon model was evaluated using computed tomography angiography and digital subtraction angiography, and the covered stent specially designed for intracranial vasculature was navigated through the siphon model for a longitudinal flexibility test. Results All dogs tolerated the procedures well, and the artificial siphon model in vivo provided realistic conditions for device testing. Two weeks later, the in vivo carotid siphon model remained patent with no thrombosis. Five covered stents were navigated to pass through five siphon models successfully, with vasospasm occurring in two siphons. Conclusion Construction of an in vivo siphon model in dogs with a glass tube is feasible and useful for the test of endovascular devices for treating neurovascular diseases.

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Section: Discussionmentioning

confidence: 99%

Construction of an in vivo carotid siphon model for testing endovascular devices for neuro-interventions

et al. 2017

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“…In vitro, cadaveric, and in vivo models have been used to evaluate endovascular devices. 3,7,10,14,15,18 In vitro models are easy to handle and are highly reproducible. They permit testing at reduced cost and without ethical considerations.…”

Section: Discussionmentioning

confidence: 99%

“…3,14,15 Cadaveric models are also suitable for testing of endovascular device, but they, too, lack the physiological responses, such as vasospasm, thrombus, and embolic complications. 7,8 In vivo models are invaluable for evaluating new materials and devices. Elements unique to in vivo models include pulsatile blood flow and vascular responses.…”

Section: Discussionmentioning

confidence: 99%

Surgical construction of a novel simulated carotid siphon in dogs

Tan¹,

Li²,

Zhang³

et al. 2008

JNS

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In Vitro Comparison of Self-Expanding Versus Balloon-Expandable Stents in a Human Ex Vivo Model

Grenacher

Rohde

Gänger

et al. 2005

Cardiovasc Intervent Radiol

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The objective was to compare the radial strength and expansile precision of self-expanding stents and balloon-expandable stents in a human cadaver bifurcation model. Seven different self-expanding (LUMINEXX, JOSTENT SelfX, JOSTENT SelfX hrf, Sinus-Repo, Sinus SuperFlex, Easy Wallstent, SMART) and four different balloon-expandable stent models (Palmaz, Sinus Stent, SAXX Medium, JOSTENT peripheral), each type 10 stents (total n = 110 stents) were implanted into the common iliac arteries of human cadaver corpses. The maximum stent diameter was 10 mm for all models. After stent implantation, the specimens were filled with silicone caoutchouc. After 24 h, the vascular walls including the stents were removed from the hardened casts. Diameters were taken and the weight of the cast cylinders was measured in air and in purified water to calculate the volume of the bodies (according to Archimedes Law) as a relative but precise degree for the radial strength of the implanted stents. The cylindrical casts of the self-expanding stents showed lower mean diameters (8.2 +/- 1.0 mm) and mean volumes (0.60 +/- 0.14 ml/cm) than in the balloon-expandable stent group (10.1 +/- 0.3 mm and 0.71 +/- 0.04 ml/cm, respectively; p < 0.01). The nominal maximum diameter of 10 mm was not achieved in any of the self-expanding stents, but this was achieved in more than 70% (29/40) of the balloon-expandable stent specimens (p < 0.05). The variation between achieved volumes was significantly larger in self-expanding (range: 0.23-0.78 ml/cm) than in balloon-expandable stents (range: 0.66-0.81 ml/cm; p < 0.05). Self-expanding stents presented considerably lower radial expansion force and lower degree of precision than balloon-expandable stents.

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Experimental Functional Analysis of Self-Expanding Stents Using a New Developed Ex Vivo Model

Cited by 7 publications

References 32 publications

Construction of an in vivo carotid siphon model for testing endovascular devices for neuro-interventions

Construction of an in vivo carotid siphon model for testing endovascular devices for neuro-interventions

Surgical construction of a novel simulated carotid siphon in dogs

In Vitro Comparison of Self-Expanding Versus Balloon-Expandable Stents in a Human Ex Vivo Model

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