Experimental osteogenesis in periapical areas with decalcified allogeneic bone matrix

Narang, Ramesh; Wells, Herbert

doi:10.1016/0030-4220(73)90108-4

Cited by 28 publications

(9 citation statements)

References 9 publications

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“…In 1889 Senn [6] showed healing of experimental canine calvarial defects and of human tibial and femoral defects with decalcified ovine bone. Others have shown bone formation in periapical areas in dogs and monkeys [7] and in skull defects in rats [8] after implantation of demineralized bone; we have recently demonstrated the usefulness of demineralized implants for bone repair and construction in the craniofacial region in rats [9].In this study, we quantitated osteogenesis induced by demineralized bone powder and evaluated the fate of demineralized and mineralized implants of comparable particle size and similar processing. Host cellular responses to the two types of implants were also examined.…”

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confidence: 99%

Fate of mineralized and demineralized osseous implants in cranial defects

1981

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We have evaluated the fate of mineralized osseous implants placed into cranial defects in rats. By 2 weeks, 100% of the defects that had been filled with demineralized bone powder (DBP, 75-250 micrometer) showed bony repair as judged by histomorphometric analysis and incorporation of 45Ca. The DBP was not appreciably resorbed but rather was amalgamated within the new bone. Histomorphometric evaluation of osteo-genesis induced by equal masses of demineralized bone powders of various particle sizes (less than 75, 75-250, 250-450 micrometer) revealed that the smaller particles induced more bone per field than did the larger particles. In contrast, mineralized bone powder (BP) was completely resorbed by 3 weeks, without bony repair of the cranial defect. These specimens contained large multinucleated cells within 7 days and completely resorbed by 3 weeks. It is concluded that (a) demineralized bone powder predictably induces a osteogenic healing of cranial defects, (b) demineralized bone powder is not appreciably resorbed prior to bone induction, (c) the extent of bone induction is a function of the surface area of the demineralized bone implant, and (d) mineralized bone powder undergoes obligatory resorption.

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confidence: 99%

Fate of mineralized and demineralized osseous implants in cranial defects

1981

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“…It was observed that both the materials were well tolerated by the patients as far as post-operative healing was concerned and did not show any allergic manifestation. According to Narang et al .,[9] the DABM's replacement with new bone was seen within 8 weeks, and the areas were completely free of any remnant of DABM graft at the end of 12 weeks. Similar is the situation with autogenous grafts.…”

Section: Resultsmentioning

confidence: 99%

“…It was concluded by the authors that demineralization and the treatment with a virucidal agent inactivates HIV in spiked and infected bone. [4] According to Narang et al .,[9] the DABM grafts do not cause any immunologic response.…”

Section: Methodsmentioning

confidence: 99%

The comparative efficacy of decalcified allogenic bone matrix and intra-oral free osseous autografts in the treatment of periodontal intrabony defects

Jindal

Gill²,

Kapoor³

et al. 2013

J Indian Soc Periodontol

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Background and Objectives:The primary goal of periodontal treatment is the maintenance of the natural dentition in health and comfortable function. The shift in therapeutic concepts from resection to regeneration has significantly impacted the practice of periodontology. The objective of the present study is to compare the relative efficacy of intra-oral autogenous graft and decalcified allogenic bone matrix (DABM) in the treatment of periodontal intrabony defects.Materials and Methods:In the present study, 30 patients in the age group of 30-50 years with two almost identical intrabony defects, on either side of the mouth/upper and lower jaw, based upon the radiographic observations were selected from amongst the patients visiting the Department of Periodontology and Oral Medicine, Punjab Government Dental College and Hospital, Amritsar. One of the defect was selected randomly and filled with autogenous cancellous graft and the other with DABM. Post-operative assessment was done by taking radiographs, 12 weeks and 24 weeks post-operatively.Results:Definite bone fill was achieved both with intra-oral free osseous autograft and with DABM at 12 weeks observation, which further increased significantly at 24 weeks observation. The bone fill obtained with intra-oral free osseous autograft was found to be significantly higher than that with DABM both at 12 weeks and 24 weeks post-operative observation.Conclusion:Within the limitations of this study, it establishes the superiority of the intra-oral free osseous autograft over that of DABM graft in correcting the intrabony defects.

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“…Various biocompatible materials have been tried as apical matrix in the past. These include: tricalcium phosphate (2), collagen calcium phosphate (3), osteogenic protein-1, bone growth factor and oxidized cellulose (4), proplast, (a polytetrafluor-ethylene and carbon felt-like porous material) (5), barium hydroxide (6), true bovine bone ceramics, and dentin chips (7). “Modified matrix concept” for repair of perforation utilized resorbable collagen as a matrix followed by condensation of MTA (8).…”

Section: Introductionmentioning

confidence: 99%

Endodontic management of open apex using MTA and platelet - rich fibrin membrane barrier: A newer matrix concept

Khetarpal¹,

Chaudhry²,

Talwar³

et al. 2013

J Clin Exp Dent

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Objectives: Endodontic management of open apex using MTA and platelet – rich fibrin membrane as an apical matrix barrier. Study design: An immature tooth with pulpal necrosis and periapical pathology imposes a great difficulty to the endodontist. Endodontic treatment options for such teeth consist of conventional apexification procedure with and without apical barriers. This article demonstrates the use of an apical matrix barrier in form of a platelet rich fibrin membrane for stabilization of MTA in root end apexification procedure. PRF is an autologous fibrin matrix containing a large quantity of platelet and leukocyte cytokines, which enhance healing by release of growth factors. These case reports present apexification and successful healing with combined use of MTA and PRF membrane as an apical barrier Results: PRF membrane can serve as an efficient apical matrix for condensation of MTA. Combination of PRF membrane and MTA is an effective method for management of difficult cases of open apex. PRF is a strong fibrin membrane enriched with platelet and growth factors that accelerate periapical healing. Key words:Apexification, apical barrier, platelet rich fibrin (PRF), mineral trioxide (MTA).

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Experimental osteogenesis in periapical areas with decalcified allogeneic bone matrix

Cited by 28 publications

References 9 publications

Fate of mineralized and demineralized osseous implants in cranial defects

Fate of mineralized and demineralized osseous implants in cranial defects

The comparative efficacy of decalcified allogenic bone matrix and intra-oral free osseous autografts in the treatment of periodontal intrabony defects

Endodontic management of open apex using MTA and platelet - rich fibrin membrane barrier: A newer matrix concept

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