Experimental photodynamic therapy for malignant pleural mesothelioma with pegylated mTHPC

Abstract

PEG-mTHPC mediated PDT showed selective destruction of mesothelioma xenografts without causing damage to intrathoracic organs in pigs at similar treatment conditions. The light delivery system afforded regular light distribution to different parts of the chest cavity.

Combination effect of photodynamic therapy using NPe6 with pemetrexed for human malignant pleural mesothelioma cells

“…this treatment modality is used for many cancers and is widely used as a treatment option for solid cancers (16)(17)(18). the use of PDt as a treatment for MPM has been investigated under both clinical and experimental conditions (19)(20)(21). friedberg et al reported a phase Ⅰ clinical trial of foscan-mediated PDt and surgery in patients with MPM (20).…”

Preclinical Comparison of mTHPC and Verteporfin for Intracavitary Photodynamic Therapy of Malignant Pleural Mesothelioma

“…Its feasibility in association with cytoreductive surgery has been shown in several clinical studies in this respect. However, the efficiency and tumour selectivity of PDT for MPM depends on the choice of the sensitizer and on the treatment conditions applied [4][5][6][7][9][10][11][12][13] . Photofrin and mTHPC were the sensitizers used for intracavitary PDT after resection in patients with MPM [4][5][6][7] .…”

“…Most of these experiments were performed on nude mice bearing human mesothelioma xenografts [8][9][10]14] or on tumour-free minipigs [13] and canines [11] . However, none of these models allows the assessment of PDT on MPM growing within the pleural cavity in an experimental setting.…”

“…Results emerging from experimental studies have suggested that modulations of the treatment conditions will influence the PDT effect on MPM and normal tissues [7][8][9][10][11][12][13] . Most of these experiments were performed on nude mice bearing human mesothelioma xenografts [8][9][10]14] or on tumour-free minipigs [13] and canines [11] .…”

Correlation of photodynamic activity and fluorescence signaling for free and pegylated mTHPC in mesothelioma xenografts

“…This has led to relevant morbidity after PDT of the chest cavity after surgery for pleural mesothelioma [1][2][3][4][5][6], even in the presence of new second generation sensitizers [7][8][9][10][11][12][13]. Several experimental studies focusing on PDT for mesothelioma have shown that enhanced tumor selectivity may be obtained by modulating treatment conditions [14][15][16][17][18] and by pegylation of the sensitizer [19,20].…”