Experimental Studies of the Effect of Schisandrachinensis Extract on the State of Adaptive Capabilities of Rats under Chronic and General Exposure to Cold

Abstract

Currently, there is an objective need to create fortified food products that allow not only to provide the body with energy, but also to replenish the deficiency of essential nutrients. A generalization of the information published by Rospotrebnadzor and the Institute of Nutrition of the Russian Academy of Medical Sciences indicates a deficiency in the diet of Russians of vitamins C, group B and β-carotene and minerals, including calcium and iron, regardless of the season of the year. The identified deviations lead to a violation of the immune status, a decrease in the body’s resistance to infections, and other unfavorable environmental factors, leading to an increase in the level of morbidity and a decrease in working capacity. The main unfavorable climatic factor that the population of the Far Eastern region has to face is low freezing temperatures. Adaptation to cold exposure is a complex process that requires a long period and may be accompanied by functional disorders and morphological changes in body tissues. In connection with the above, the problem of increasing the adaptive capabilities of a person to unfavorable environmental factors by means of correcting daily nutrition, providing the body with essential macro- and micronutrients, which is important in the prevention of possible diseases, is of particular importance. This study is aimed at assessing the effect of Schisandrachinensis extract on the adaptive capacity of rats in conditions of chronic and general cold. It was found that the extracts obtained from the fruits of Schisandra chinensis are characterized by a high content of biologically active substances. In experiments with determining the duration of running on the treadmill, a distinct act-protective effect was observed with the introduction of Schisandra chinensis extracts at a dose of 150 mg/day, against the background of reduced resistance to physical activity due to cold exposure. It was found that exposure to cold significantly reduced the swimming resistance of rats on all days of the study. The introduction of Schisandra chinensis extract into the diet led to an increase in resistance to fatigue and an increase in the duration of swimming on all days of the experiment. Conclusions: in this experimental model, a gradually increasing effect of increasing the physical performance of rats was demonstrated with prolonged (28 days) intake of the developed drinks, which coincides with the literature data on a number of other adaptogens and indicates the presence of cumulative properties of biologically active substances of Schisandra extract.

The influence of the Ukrainian phytocomposition "Balm Truskavets'" on parameters of neuro-endocrine-immune complex and biophotonics in humans with maladaptation

“…Sergeeva I et al [56] give a different classification of phenols. In accordance with the pathways of biosynthesis in plants, phenolic compounds are subdivided into eight groups: compounds of the C6 series, or simple phenols; compounds of the C6-C1 series, or phenolic acids (derivatives of benzoic acid); C6-C2 compounds, or phenolic alcohols and phenylacetic acids; compounds of the C6-C3 series, or hydroxycinnamic acids, phenylpropenes, and coumarins; compounds of the C6-C4 series, or flavonoids or isoflavonoids, as well as lignins and polymeric phenolic compounds-lignin, tannins, and melanins.…”

Similarity of adaptogenic effects of bioactive naftussya water and phytocomposition “Balm Truskavets’”

“…The most investigated medicinal herbs for their adaptogenic activity are Panax ginseng, Eleutherococcus senticosus, Withania somnifera, Schisandra chinensis, Rhaponticum carthamoides, Lepidium meyenii, and Rhodiola spp. Phytochemicals that have been demonstrated adaptogenic properties mainly belong to polyphenolic compounds [14,36,42,52]. Currently, we do not have data on the chemical composition of the "Balm Truskavets'".…”