Experimental study and clinical application of polyglycolic acid sheet with fibrin glue for oral soft tissue surgery

Inokuchi, Satoshi; Rokutanda, Satoshi; Yanamoto, Souichi; Naruse, Tomofumi; Sakamoto, Yuki; Umeda, Masahiro

doi:10.1016/j.ajoms.2017.02.006

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…Importantly, Kibe et al [16] reported that there was little invasion of epithelial cells into PGA, whereas epithelial cells multiplied on the surface of granulation tissue in open wounds. In an animal experiment, Inokuchi et al [17] showed that the area of scar tissue in a group without any graft was deeper and narrower than that in a group with PGA-covered wounds. This finding indicates that a PGA covering is likely to induce scar formation with a wide surface area, which leads to moderate contracture.…”

Section: Discussionmentioning

confidence: 99%

Dental Rehabilitation for Free Fibula Flap-Reconstructed Mandible with Scar Contracture: A Technical Note

et al. 2019

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Dental rehabilitation with osseointegrated implants in reconstructed mandibles is a common procedure, but the technique still requires improvement, especially in its reliability and technical simplification. We herein report dental rehabilitation of a free fibula-reconstructed mandible with scar contracture. A vestibuloplasty technique with application of a polyglycolic acid (PGA) sheet is described. The implants were inserted into a viable fibula flap with severe scar contracture of the overlying epithelium resulting from vascular instability in skin paddle. Only the fibula periosteum was sutured after implant insertion; exposed surfaces were covered with a combination of PGA sheet and fibrin sealant. The area with PGA sheet coverage gradually healed with moderate contracture. The epithelium around the almost implants became immobilized. The implant-supported removable partial denture with custom titanium bar was acceptable. Dental rehabilitation is possible for reconstructed mandibles with severe scar contracture. Application of a PGA sheet may be useful for vestibuloplasty in patients with reconstructed mandibles.

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Section: Discussionmentioning

confidence: 99%

Dental Rehabilitation for Free Fibula Flap-Reconstructed Mandible with Scar Contracture: A Technical Note

et al. 2019

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“…[10][11][12][13][14] There were a few reports on the use of PGA sheets in the oral and maxillofacial region. [1][2][3][4]6,15 There are no selection criteria for covering oral mucosal open wounds. Split-thickness skin grafting (STSG) was reported as a beneficial surgical procedure if the defect size in the tongue was ≥12 cm 2 .…”

Section: Discussionmentioning

confidence: 99%

“…After resection, PGA sheets with a thickness of 0.15 mm were applied with fibrin glue. [6][7][8] After hemostasis of the raw surfaces, about 1 mL of solution A of the fibrin glue was rubbed on the raw surfaces with the surgeon's finger. Then a PGA sheet was cut to a size somewhat smaller than the wound, or it was cut into small pieces (5-7 mm square) and affixed to the wound, and a mixture of 4 mL of each of solution A and solution B of the fibrin glue was sprayed onto the sheets and the surrounding region using a specialized spray kit.…”

Section: Resection Pga Sheet Application and Follow-upmentioning

confidence: 99%

Clinical complications in the application of polyglycolic acid sheets with fibrin glue after resection of mucosal lesions in oral cavity

Okuyama

Yanamoto

Naruse

et al. 2018

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…Therefore, PGA and its derivatives have been employed in medical fields such as drug delivery and dental and orthopedic systems ( Takimoto et al, 2014 ; Sakaguchi et al, 2016 ; Sharma and Sharma 2018 ), and PGA sheets, as a form of tissue engineering scaffold, are widely used in gastrointestinal field. In Japan, PGA sheets have been used to promote wound healing after resection of oral tumors ( Inokuchi et al, 2017 ). In the recent decade, PGA sheets (Neoveil; Gunze Co., Kyoto, Japan) are applied in endoscopic technology for the closure of perforations and postoperative homeostasis.…”

Section: Biomedical Polymersmentioning

confidence: 99%

Recent Advances of Biomedical Materials for Prevention of Post-ESD Esophageal Stricture

Bao

et al. 2021

Front. Bioeng. Biotechnol.

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Esophageal stricture commonly occurs in patients that have suffered from endoscopic submucosal dissection (ESD), and it makes swallowing difficult for patients, significantly reducing their life qualities. So far, the prevention strategies applied in clinical practice for post-ESD esophageal stricture usually bring various inevitable complications, which drastically counteract their effectiveness. Nowadays, with the widespread investigation and application of biomedical materials, lots of novel approaches have been devised in terms of the prevention of esophageal stricture. Biomedical polymers and biomedical-derived materials are the most used biomedical materials to prevent esophageal stricture after ESD. Both of biomedical polymers and biomedical-derived materials possess great physicochemical properties such as biocompatibility and biodegradability. Moreover, some biomedical polymers can be used as scaffolds to promote cell growth, and biomedical-derived materials have biological functions similar to natural organisms, so they are important in tissue engineering. In this review, we have summarized the current approaches for preventing esophageal stricture and put emphasis on the discussion of the roles biomedical polymers and biomedical-derived materials acted in esophageal stricture prevention. Meanwhile, we proposed several potential methods that may be highly rational and feasible in esophageal stricture prevention based on other researches associated with biomedical materials. This review is expected to offer a significant inspiration from biomedical materials to explore more effective, safer, and more economical strategies to manage post-ESD esophageal stricture.

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Experimental study and clinical application of polyglycolic acid sheet with fibrin glue for oral soft tissue surgery

Cited by 6 publications

References 7 publications

Dental Rehabilitation for Free Fibula Flap-Reconstructed Mandible with Scar Contracture: A Technical Note

Dental Rehabilitation for Free Fibula Flap-Reconstructed Mandible with Scar Contracture: A Technical Note

Clinical complications in the application of polyglycolic acid sheets with fibrin glue after resection of mucosal lesions in oral cavity

Recent Advances of Biomedical Materials for Prevention of Post-ESD Esophageal Stricture

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