In Oil and gas productions, the severe slug is an undesired flow regime due to the negative impact on the production rate and facility safety. This study examines the severe riser-induced slugs’ influence on a typical separation process, consisting of a 3-phase gravity separator physically linked to a deoiling hydrocyclone. Four inflow scenarios are compared: Uncontrolled, open-loop, feasible, and infeasible closed-loop anti-slug control, respectively. Three PID controllers’ coefficients are kept constant for all the tests: The separator pressure, water level, and hydrocyclone pressure-drop-ratio (PDR) controllers. The simulation results show that the separation efficiency is significantly larger in the closed-loop configuration, probably due to the larger production rates which provide a preferable operation condition for the hydrocyclone. It is concluded that both slug elimination approaches improve the separation efficiency consistency, but that the closed-loop control provides the best overall separation performance.