Experimental Study on Alcoholic Pancreatitis

Maki, Tetsuo; Kakizaki, G; Sato, Toshio; Saito, Yoichi; Onuma, Toshiyuki; Noto, Noboru

doi:10.1620/tjem.92.415

Cited by 8 publications

(2 citation statements)

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“…Alcohol-related CP models. In 1967, Maki et al (106) studied the influence of the oral administration of alcohol on the rat pancreas and the interaction of alcohol with various dietary compositions. Alcohol with a concentration of 15% was added to the drinking water of the study animals for 2 mo.…”

Section: Animal Models Of Chronic Pancreatitismentioning

confidence: 99%

Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis

Zhan

Wang

et al. 2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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Animal models of pancreatitis are useful for elucidating the pathogenesis of pancreatitis and developing and testing novel interventions. In this review, we aim to summarize the most commonly used animal models, overview their pathophysiology, and discuss their strengths and limitations. We will also briefly describe common animal study procedures and refer readers to more detailed protocols in the literature. Although animal models include pigs, dogs, opossums, and other animals, we will mainly focus on rodent models because of their popularity. Autoimmune pancreatitis and genetically engineered animal models will be reviewed elsewhere.

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Section: Animal Models Of Chronic Pancreatitismentioning

confidence: 99%

Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis

Zhan

Wang

et al. 2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…D eclo itre et al [6] found a significant fall in the pancreatic content of total and inorganic phosphate, ester phosphate, total adenylate nucleotides and adenosine monophosphate, 1 h after a 3 g/kg dose of ethanol intraperitoneally. M a k i et al [11], giving 15% ethanol for 2 months to 6 groups of Wistar rats receiving different diets, observed pancreatic steatosis and oedema in the groups fed with high lipid and/or high protein diets. Sardesai et al [13], in Sprague-Dawley rats fed 20% ethanol and a commercial diet containing nearly 24% proteins for 48 weeks, found that, in the pancreas, the trypsinogen and ribonuclease levels, the incorporation of DL-leucine-l-14C into proteins and the oxygen uptake decreased progressively.…”

mentioning

confidence: 99%

The Interaction of Ethanol, Dietary Lipids, and Proteins on the Rat Pancreas

1971

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124 male Wistar rats weighing 80–120 g were randomized into 2 groups, one receiving ad libitum 20% ethanol, the other water as drinking fluid. Each group has been divided in series of 8 to 12 rats which received 4 different diets combining different ratios of casein and fats. The experiments lasted from 2 to 21 months. Trypsinogen, amylase, lipase, protein and DNA were measured at the end of the experiment. The action of ethanol is closely related to the dietary ratio of proteins and lipids: (1) With a 17–18.5% protein intake and a 10% lipid diet, amylase and chrymotrypsinogen are significantly reduced, but with a 35% fat diet, amylase, trypsinogen and chymotrypsinogen are increased as well as, very probably, the enzyme concentration in the zymogen granules. This increased concentration might explain the toxic action of ethanol in man, facilitating precipitation of protein plugs in the ducts, found in the first stage of chronic alcoholic calcifying pancreatitis. (2) With a 5–6% protein diet, ethanol lowers moderately the pancreaticconcentration of these enzymes. With increased lipid ratios of the diet, the level of thepancreatic enzymes is reduced.

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