Experimental study on the hemostatic effect of cyanoacrylate intended for catheter securement

Zhou, Sheng; Guido, Amanda; Jones, Richard G.; Curry, Benjamin J.; Burke, Angela S.; Blaisdell, Melanie E

doi:10.1177/1129729818779702

Cited by 9 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This indicates that CAG is a promising application at reducing bleeding after VAD insertion, but haemostasis must be in place prior to application. These properties have been observed in vitro and in vivo in pigs 18 at 3, 6, 9 and 12 min after treatment. It has also been seen with different VADs: PICCs, 7 , 14 , 30 CICCs 11 and arterial catheters.…”

Section: Discussionmentioning

confidence: 73%

“… 13 Their safe use has been verified in adults, 14 paediatric patients 15 and neonatal patients. 16 , 17 CAG has also been shown to have a strong haemostatic effect in the presence of blood, 18 and its long-term use does not damage polyurethane catheters. 19 On the negative side, it has been suggested that its use might not be suitable for patients with sensitive skin or cutaneous diseases, and healthcare personnel training has been recommended as cases have been reported of tissue damage due to incorrect removal of the product.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of cyanoacrylate glue in the fixation of midline catheters and peripherally inserted central catheters in hospitalised adult patients: Randomised clinical trial (CIANO-ETI)

et al. 2023

View full text Add to dashboard Cite

Objective: The objective of the study was to assess the efficacy of the use of cyanoacrylate glue (CAG) as a means of securing midline catheters and peripherally inserted central catheters with the modified micro-Seldinger technique in adult hospitalised patients. Methods: Randomised clinical trial with two groups (1:1): control and intervention. The control group received a securement method with a sutureless device plus transparent dressing and the intervention group received the same securement method plus the CAG. The study was approved by the Drug Research Ethics Committee of the Lleida Health Region. Results: A total of 216 patients were assessed. The two groups of the trial were homogenously distributed in terms of sociodemographic and clinical variables. The intervention group had a statistically significant lower incidence of peri-catheter bleeding and/or oozing during the 7-day study period (odds ratio (OR), 0.6; 95% confidence level (CI), 0.44–0.81; p < 0.001) and a statistically significant lower incidence of catheter dislodgements during the first 24 h (OR, 0.2; 95% CI, 0.04–0.91; p = 0.03). There were no statistically significant differences in the incidence of phlebitis (OR, 1.30; 95% CI, 0.60–2.83; p = 0.56) or catheter-related pain (OR, 0.88; 95% CI, 0.40–1.94; p = 0.84). Conclusion: Midline catheters and peripherally inserted central catheters secured with CAG had fewer complications than catheters not secured with this adhesive.

show abstract

Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Effectiveness of cyanoacrylate glue in the fixation of midline catheters and peripherally inserted central catheters in hospitalised adult patients: Randomised clinical trial (CIANO-ETI)

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Although cyanoacrylates have excellent mechanical hemostasis, they cannot promote blood coagulation 43 . SNPs can accelerate blood coagulation by promoting the aggregation of platelets and red blood cells 25,26 .…”

Section: Resultsmentioning

confidence: 99%

“…Although cyanoacrylates have excellent mechanical hemostasis, they cannot promote blood coagulation. 43 SNPs can accelerate blood coagulation by promoting the aggregation of platelets and red blood cells. 25,26 Recalcification clotting measurements were carried out to assess the coagulation efficiency of the samples.…”

Section: Coagulation Propertiesmentioning

confidence: 99%

Effects of methoxy polyethylene glycol‐polycaprolactone block copolymers and silica nanoparticles on the mechanical, tissue affinity and antibacterial properties of n‐butyl cyanoacrylate adhesive

Jin²,

2023

J of Applied Polymer Sci

View full text Add to dashboard Cite

Cyanoacrylates are widely used as surgical tissue adhesives because of their high biodegradability, but they are brittle and have poor tissue affinity. In this study, methoxy polyethylene glycol‐polycaprolactone block copolymers (MPEG‐co‐PCLs) with different PCL chain lengths were synthesized by ring‐opening polymerization. Then, a new tissue adhesive with excellent mechanical properties, tissue affinity, antibacterial properties, and coagulation performances was prepared by incorporating MPEG‐co‐PCL and silica nanoparticles (SNPs) into n‐butyl cyanoacrylate (BCA). The optimal MPEG: PCL ratio is 1:4 (MP‐3), and the optimal mass ratio of MPEG‐co‐PCL and SNPs (0.5SNPs/0.5MP‐3) is 0.5 wt.%. Compared to BCA, the adhesion strength and flexibility of 0.5SNPs/0.5MP‐3 are dramatically improved by 110% and 244%, respectively. MPEG‐co‐PCL can fully exploit the advantages of homopolymers, and therefore, improve the tissue affinity and adhesion strength of the adhesive and avoid BCA polymerization initiated by MPEG and poor compatibility of PCL with BCA. SNPs can also compensate for the lack of antibacterial properties of BCA against Gram‐negative bacteria. The E. coli inhibition circle of 0.5SNPs/0.5MP‐3 is twice as large as BCA. SNPs can also improve coagulation by promoting platelet aggregation. This work provides an effective strategy for developing adhesives with potential clinical applications.

show abstract

“…The third study reviewed measured the effect of hemostasis of one CSCA, SecurePortIV, through in vitro and in vivo testing methods 42. The data from the in vitro tests demonstrated that SecurePortIV achieved consistent inhibition of blood flow and rapidly modified activated clotting times.…”

Section: Discussionmentioning

confidence: 99%

A Revolutionary, Proven Solution to Vascular Access Concerns: A Review of the Advantageous Properties and Benefits of Catheter Securement Cyanoacrylate Adhesives

Zhang

Lingle

Phelps

2022

Journal of Infusion Nursing

Self Cite

View full text Add to dashboard Cite

Intravascular catheters are widely used among hospitals; however, their failure rates are high, up to 50%, when secured by traditional techniques, such as tape and gauze. The use of catheter securement cyanoacrylate adhesives provides a unique approach to the issues surrounding the use of traditional securement techniques for vascular access devices by providing significant securement strength, barrier properties, antibacterial properties, hemostatic properties, and flexibility. The purpose of this research was to perform a thorough and systematic review of the current literature existing regarding the use of cyanoacrylate adhesive for the care and maintenance of vascular access devices.

show abstract

Experimental study on the hemostatic effect of cyanoacrylate intended for catheter securement

Cited by 9 publications

References 19 publications

Effectiveness of cyanoacrylate glue in the fixation of midline catheters and peripherally inserted central catheters in hospitalised adult patients: Randomised clinical trial (CIANO-ETI)

Effectiveness of cyanoacrylate glue in the fixation of midline catheters and peripherally inserted central catheters in hospitalised adult patients: Randomised clinical trial (CIANO-ETI)

Effects of methoxy polyethylene glycol‐polycaprolactone block copolymers and silica nanoparticles on the mechanical, tissue affinity and antibacterial properties of n‐butyl cyanoacrylate adhesive

A Revolutionary, Proven Solution to Vascular Access Concerns: A Review of the Advantageous Properties and Benefits of Catheter Securement Cyanoacrylate Adhesives

Contact Info

Product

Resources

About