Experimentally validated vibro-acoustic modeling of 3D bio-printed grafts for potential use in human tympanic membrane regeneration

Tunable ciprofloxacin delivery through personalized electrospun patches for tympanic membrane perforations

“…However, with the growing prominence of tissue engineering, several biomaterial- and biofabrication-based strategies are being investigated for reconstructing the perforated TM with a superior biological and mechano-acoustical response [ [19] , [20] , [21] , [22] , [23] ]. A wide range of natural and synthetic polymers, spanning from silk fibroin [ 24 , 25 ], alginate [ 26 ], gelatin [ 27 , 28 ] to poly(ε-caprolactone) [ [29] , [30] , [31] , [32] ], and poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT) [ 19 , [33] , [34] , [35] , [36] ] have been studied for this purpose in combination with biofabrication techniques, such as electrospinning (ES) [ 19 , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] ] and additive manufacturing [ [19] , [20] , [21] , 28 , 29 , 33 , 41 , 42 ]. The ability to create nanofibrous electrospun patches with dimensions similar to those of native collagen fibrils in the extracellular matrix [ 43 ] supports as a promising approach for reconstructing CSOM-induced injuries using tissue-engineered scaffolds.…”