Experimentelle Untersuchung über den Zusammenhang zwischen Nierenerkrankung und Herzhypertrophie

Grawitz, Paul; Israel, Oscar

doi:10.1007/bf01929770

Cited by 30 publications

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“…According to Rambausek et al . [ 37 ], the first recorded increase in heart weight secondary to experimental renal failure was in 1879 [ 38 ]. However it was the study by Rambausek et al .…”

Section: Uraemic Cardiomyopathy: An Example Of Lessons Learnedmentioning

confidence: 99%

Experimental Models of Renal Disease and the Cardiovascular System

Grossman¹

2010

TOCMJ

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Cardiovascular disease is a leading cause of death among patients with end stage renal failure. Animal models have played a crucial role in teasing apart the complex pathological processes involved. This review discusses the principles of using animal models, the history of their use in the study of renal hypertension, the controversies arising from experimental models of non-hypertensive uraemic cardiomyopathy and the lessons learned from these models, and highlights important areas of future research in this field, including de novo cardiomyopathy secondary to renal transplantation.

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Section: Uraemic Cardiomyopathy: An Example Of Lessons Learnedmentioning

confidence: 99%

Experimental Models of Renal Disease and the Cardiovascular System

Grossman¹

2010

TOCMJ

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“…The earliest experimental approaches to hypertension were devoted primarily to determining the effect of ne phrectomy and other manipulations of the kidney on the blood pressure and renal excretory function. In 1879 Grawitz and Israel induced hypertrophy of the heart by par tial nephrectomy in rabbits, which they attributed to the development of hypertension [ 10]. Later, Passler and Heineke demonstrated an increase in blood pressure by the same procedure in dogs [11].…”

Section: Experimental Renal Hypertensionmentioning

confidence: 99%

Hypertension as Cause and Consequence of Renal Disease in the 19th Century

Harlos

Heidland²

1994

Am J Nephrol

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The pioneering work of Richard Bright, who introduced the concept of the renal origin of cardiovascular disease, initiated the continuous unfolding of knowledge on renal disease and its close interrelationship with arterial hypertension in the 19th century. Hypertension as a clinically and pathologically defined entity, however, was not established. The partial elucidation of the problem that the diseased kidney was sometimes the cause and sometimes the consequence of elevated blood pressure is not only fascinating but also remarkable, given the crude techniques available to physicians at that time. Subsequent workers came to regard ‘Bright’s disease’ as consisting of several conditions differing in clinical manifestation and pathology. In particular, Johnson and Gull and Sutton drew attention to the small blood vessels in renal disease. Only the invention of a clinically applicable method of measuring blood pressure indirectly allowed Mahomed and Allbutt to show that hypertension may occur in the absence of renal disease. They paved the way for a clear separation of hypertensive renal disease from other forms of ‘Bright’s disease’, culminating in the classification introduced by Fahr and Volhard.

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“…He also observed a considerable and itz and Israel occluded one renal artery of the rabbit for permanent increase in systolic blood pressure (to 171 short periods and directly measured blood pressure in mm Hg) and sclerotic changes in the aorta [46]. The the carotid artery using a newly constructed device [40].…”

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confidence: 99%

“…kidneys of his animals revealed a mixture of "regenera-Although Grawitz and Israel could not detect an increase tive and atrophic" processes with an increase in interstiin blood pressure, they found evidence of "compensatial connective tissue. tory" cardiac hypertrophy [40]. Lewinski constricted re-In 1911, Senator used direct liquid paraffin injections into the renal arteries of cats to induce a bilateral partial nal arteries of both kidneys in dogs using silk or catgut obstruction [47].…”

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confidence: 99%

Franz Volhard and his students' tortuous road to renovascular hypertension

Wolf¹

2000

Kidney International

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Franz Volhard and his students' tortuous road to renovascular hypertension. Harry Goldblatt's name is irrevocably linked to the phenomenon that renal artery constriction increases blood pressure via renin release, even in the absence of significantly decreased renal function. However, "getting there was more than half the fun." A lively competition took place earlier in this century elucidating the role of the kidney in hypertension, in which Franz Volhard and his disciples played a major role. I have reviewed the extensive German literature of the time, and observed that Franz Volhard and his young associates made major contributions investigating decreases in renal perfusion and resultant increases in blood pressure. Hessel, Hartwich, and Volhard made seminal observations in this regard that even preceded those of Goldblatt. A sojourn into this past history gives a revealing insight into our cumulative-albeit still incomplete-knowledge of the kidney, renin-angiotensin system, and blood pressure regulation. Franz Volhard was a colorful figure whose contributions extended far beyond classifying renal diseases.

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Experimentelle Untersuchung über den Zusammenhang zwischen Nierenerkrankung und Herzhypertrophie

Cited by 30 publications

References 0 publications

Experimental Models of Renal Disease and the Cardiovascular System

Experimental Models of Renal Disease and the Cardiovascular System

Hypertension as Cause and Consequence of Renal Disease in the 19th Century

Franz Volhard and his students' tortuous road to renovascular hypertension

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