Experimenteller Hermaphroditismus

Sand, Knud

doi:10.1007/bf01722104

Cited by 21 publications

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“…It seems very likely that in all the phenomena concerning hypertrophy of the generative part of the sexual glands some factor is involved which has not yet been taken into consideration. Arguing from experiments with simultaneous transplantation of testicle and ovary in the*same animal and from experiments upon intra-testicular transplantation of the ovary, Sand (11) suggested that in every organism certain substances are to be found which are necessary for the development of the sexual glands. It is not impossible that such a factor might influence the result of partial castration.…”

Section: IVmentioning

confidence: 99%

Further experimental investigations on the hypertrophy of the sexual glands

1922

Proc. R. Soc. Lond. B.

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In reference to my recent paper,* in consequence of criticism received privately from Mr. Ritchie, I re-investigated the use of the manganese dioxide electrode, and discovered a fault in my technique which invalidates the con clusions drawn.This fault was that the electrode was not shielded so as to prevent the muscle from touching a portion of the electrode with which it was not in equilibrium When the tension of the muscle increased there was a tendency for the muscle to straighten between the two points of attachment, and this lifted it, slightly bringing it into contact with a fresh surface of the electrode.I wish, therefore, to acknowledge that the method of investigating living tissues by electrodes, described in my paper, is unsatisfactory, and the results obtained do not indicate the development of acid in the muscle. Further Experimental Investigations on the Hypertrophy of the Sexual Glands.By A lexander L ip s c iiu t z , M.D., Professor of Physiology, University of Dorpat (in collaboration with D r . Charles W a g n er , D r. R obert T amm and F e l ix B orm ann).

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Section: IVmentioning

confidence: 99%

Further experimental investigations on the hypertrophy of the sexual glands

1922

Proc. R. Soc. Lond. B.

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Studies on the physiology of lactation. I. The relation of lactation to the ovarian and hypophyseal hormones

Nelson

Pfiffner

1931

Anat. Rec.

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Studies on the anterior hypophysis. III. The anterior hypophysis in vitamine E‐deficient rats

Nelson

1933

Anat. Rec.

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The effects of castration upon the cytological picture of the rat hypophysis has been described by Addison ( '17). This author has shown that the basophiles enlarge markedly following gonadectomy, this enlargement finally attaining the so-called 'signet-ring' condition. Engle ( '29) and Evans and Simpson ( '29) consider this enlargement as indicating the storage of the gonad-stimulating hormone, because they were able to show that the hypophyses of gonadectomized rats are more potent than glands from normal animals in their capacity to stimulate the immature ovary. However, Emery's ('32) demonstration that the hormone occurs in the blood of castrated rats-a condition not present in normal animalsindicates that the gonad-stimulating factor is not confined to the hypophysis in castrated animals.These studies, as well as a number of others, especially those of Moore and Price ('32), are evidence for the existence of a reciprocal relationship between the gonads and the m t erior hypophysis. Thus the gonads are stimulated through the agency of the pituitary hormone, but the gonadal hormones exercise an inhibitory influence on the hypophysis. Removal of the pituitary causes gonadal regression, but gonadectomy permits abnormal pituitary activity.Inasmuch as gonadectomy in the male removes all of the testicular elements, it becomes of interest to inquire into the gonad-pituitary relations of animals in which only certain National Research Council Fellow 241

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Experimenteller Hermaphroditismus

Cited by 21 publications

References 0 publications

Further experimental investigations on the hypertrophy of the sexual glands

Further experimental investigations on the hypertrophy of the sexual glands

Studies on the physiology of lactation. I. The relation of lactation to the ovarian and hypophyseal hormones

Studies on the anterior hypophysis. III. The anterior hypophysis in vitamine E‐deficient rats

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