Explaining cyclodextrin–mycotoxin interactions using a ‘natural’ force field

Interactions of zearalenone with native and chemically modified cyclodextrins and their potential utilization

“…The most abundant cyclodextrins are a-, b-, and c-CDs (are built up from six, seven and eight glucopyranose unites, respectively). Previous studies highlighted that b-CDs are able to form stable complexes with different mycotoxins such as citrinin, aflatoxin B1, ochratoxin A and zearalenone [11][12][13][14][15]. The complex formation commonly results in the fluorescence enhancement of the fluorescent mycotoxins therefore some of these interactions are suitable to develop more sensitive fluorescent analytical methods [16].…”

Fabrication of modular multifunctional delivery for antitumor drugs based on host–guest recognition

“…With the increasing molar ratio of CD added to the quantitative Dex-BM solution, the fluorescence intensity significantly increased as shown in Fig. 2 because the fluorescent molecules would increase their fluorescence intensity as they were staying in the hydrophobic cavity, such as CD [28], indicating the successful association between BM and CD by host-guest recognition.…”

Use of cyclodextrins as modifiers of fluorescence in the detection of mycotoxins

“…This suggests that the dianion form of OTA interacts more strongly with -CD than the protonated form. Molecular modelling simulations have also suggested that the phenylalanine portion of OTA is involved in the inclusion complexation with -CD (Amadasi et al 2007). …”

“…When -CD is added the interactions of the carbonyls with the water may be decreased, increasing AFB 1 fluorescence (Ramírez-Galicia et al 2007). Based on models of the docking of AFB 1 with -and -CDs it has been suggested that inclusion of the fluorophore into the CD cavity may reduce the quenching effect of the solvent, thereby enhancing fluorescence (Amadasi et al 2007). The exact mechanism of interaction of the CDs with aflatoxins has not been reported, although formation of a 1 : 1 inclusion complex has been suggested (Dall'Asta et al 2003).…”

“…The exact mechanism of interaction of the CDs with aflatoxins has not been reported, although formation of a 1 : 1 inclusion complex has been suggested (Dall'Asta et al 2003). Recently modelling studies have also suggested the dihydrofuran portion of AFB 1 is inserted into -CD, with possible hydrogen bonding between the carbonyl groups of the toxin and the secondary hydroxyl groups of the CD (Amadasi et al 2007). It should be noted that significant enhancement of aflatoxin emission has generally required using high ratios of CD: aflatoxin, ranging from more than 10 3 : 1 to 10 5 : 1.…”