Exploration of metabolite signatures using high-throughput mass spectrometry coupled with multivariate data analysis

Abstract

Disease impacts important metabolic pathways and the alteration of metabolites may serve as a potential biomarker for early-stage diagnosis.

Differential diagnosis of human lung tumors using surface desorption atmospheric pressure chemical ionization imaging mass spectrometry

“…[42][43][44][45][46]55,56 A signi-cant increase in multiple phosphatidylcholines (PCs) and a decrease in several specic sphingomyelins (SMs) were observed from tumor to adjacent normal tissue particularly, enhanced levels of choline (C 5 in the MALDI-Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR MS), the potassium or sodium adducts form mechanism of which is the same as the result of this study. 46,58 Different formations of these ions produced are contributed to the different main ionization mechanisms of ESI and DAPCI, which are complementary for compounds identi-cation and potential biomarkers discovery.…”

Characterization of chemical constituents and absorbed components, screening the active components of gelanxinning capsule and an evaluation of therapeutic effects by ultra‐high performance liquid chromatography with quadrupole time of flight mass spectrometry

“…Lipids metabolism makes metabolomics a more promising way to explore these types of diseases as the core issues in CVD. Application of metabolomics in clinical research has provided the chance to obtain new insights into metabolic change and mechanism [62][63][64]. A large amount of information bringing about by metabolomics indicated that these approaches will open a new perspective on disease processes and eventually transit from theory to clinical applications [65][66][67][68][69][70].…”

Metabolomics biotechnology, applications, and future trends: a systematic review

“…[126][127][128][129] Numerous studies have also been tested, including early disease detection, treatment prediction and prognosis, monitoring treatment and recurrence testing. [130][131][132][133][134][135][136][137][138][139] Given the extreme complexity of biological mixtures, most MS analytical methods involve the use of LC, GC or CE. However, rapidly growing applications using evolving separation methods and protocols offer opportunities and challenges.…”