Exploration of the Relationship between Interleukins 17, 37 and 38 with Vitamin E in Iraqi Men with CHB.

Abstract

Hepatitis B is a possibly life-threatening liver contagion produced by the hepatitis B virus (HBV). It is a main worldwide health issue. It can cause chronic contagion & puts societies at great danger of death from cirrhosis & liver malignancy. The goal of the current research was to measure four important parameters in cases with chronic hepatitis B (CHB) (the amount of IL-17, IL-37, IL-38 & vitamin E). These factors were surveyed in CHB patients to compare with healthy controls & study the association among these markers with other parameters in the study. Population consists of 40 patients diagnosed with CHB & a healthy controls (HC) group of 39 person. IL-17, IL-37, IL-38 & vitamin E levels were assessed in all subjects by using available ELISA kits from Mybiosource company; USA. serum concentrations of IL-17 & IL-37 were importantly greater in HBV group compared to control group, while serum levels of IL-38 & vitamin E were importantly lesser in CHB cases compared to HC also vitamin E showed weakly negative correlation with IL-17 & weakly positive correlation with IL-37 & IL-38. The study recommends that IL-17 & IL-37 levels may be a useful indicator to identification HBV in primary phases so that we should monitor these markers concentrations in blood of constantly to sustain their health.

The emerging role of IL‐38 in diseases: A comprehensive review

“…Gao et al 49 revealed that the level of IL‐38 and IL‐36α was significantly elevated in patients with influenza and COVID‐19, in which IL‐38 level was negatively and IL‐36α was positively associated with infection severity. Wang et al 50 showed elevated level of IL‐38 in patients with chronic hepatitis B, suggesting that IL‐38 could be used as a biomarker for liver hepatitis infection and liver injury 51 . Fazeli et al 52 reported that the level of IL‐38 was higher in healthy subjects than treated HCV‐infected patients, and HCV‐infected patients with higher levels of IL‐38 indicated less liver damage.…”

“…Wang et al 50 showed elevated level of IL‐38 in patients with chronic hepatitis B, suggesting that IL‐38 could be used as a biomarker for liver hepatitis infection and liver injury. 51 Fazeli et al 52 reported that the level of IL‐38 was higher in healthy subjects than treated HCV‐infected patients, and HCV‐infected patients with higher levels of IL‐38 indicated less liver damage. In sepsis mice model, the level of IL‐38 increased and IL‐38 could prolong the survival of mice.…”

Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study

“…In another study, immunobiological factors such as vitamin E, IL-17, IL-37, and IL-38 were assessed in Iraqi male patients with chronic hepatitis B (CHB). Although they reported diminished expression levels of IL-38 and vitamin E in patient groups compared to the healthy controls, they did not recommend monitoring concentrations of IL-38 for the identification of patients with CHB and the assessment of risk stratification [205].…”

Studying Neudesin marker in Iraqi Thyroid Dysfunction Patients

“…However, hyperthyroidism may cause abnormally low cholesterol levels or an improvement in lipid profile for no apparent reason [12]. Many Iraqi studies have examined the relationship between inflammatory variables and various diseases [13,14], but this study is the first to study the relationship of neudesin to thyroid dysfunction.…”