Exploratory analysis of neuropsychological and neuroanatomical correlates of progressive mild cognitive impairment in Parkinson's disease

Lee, Ji E.; Cho, Kyoo Ho; Song, Sook Keun; Kim, Hee Jin; Lee, Hye Sun; Sohn, Young H.; Lee, Phil Hyu

doi:10.1136/jnnp-2013-305062

Cited by 127 publications

(119 citation statements)

References 53 publications

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“…30 A previous imaging study also showed atrophy of the caudate nucleus and frontal cortex in patients with PD-MCI who subsequently converted to PD with dementia compared with those without conversion to PD with dementia. 31 Furthermore, our results showed that frontostriatal RSFC had significant correlation with the duration of parkinsonism before MCI. In other words, patients with more disrupted RSFC among these areas had MCI with a shorter interval after the onset of motor symptoms.…”

Section: Discussionmentioning

confidence: 50%

Different Functional and Microstructural Changes Depending on Duration of Mild Cognitive Impairment in Parkinson Disease

Shin

Lee³

et al. 2015

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE:The higher cortical burden of Lewy body and Alzheimer disease-type pathology has been reported to be associated with a faster onset of cognitive impairment of Parkinson disease. So far, there has been a few studies only about the changes of gray matter volume depending on duration of cognitive impairment in Parkinson disease. Therefore, our aim was to evaluate the different patterns of structural and functional changes in Parkinson disease with mild cognitive impairment according to the duration of parkinsonism before mild cognitive impairment.

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Section: Discussionmentioning

confidence: 50%

Different Functional and Microstructural Changes Depending on Duration of Mild Cognitive Impairment in Parkinson Disease

Shin

Lee³

et al. 2015

American Journal of Neuroradiology

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“…left inferior frontal gyrus and anterior cingulate cortex) in activating conscious attention and mediating inhibitory control (Nee et al 2007). These brain areas have been found to be of particular interest by neuroimaging studies investigating cognitive impairment in PD-MCI (Lee et al, 2014). Moreover, significant correlations between scores obtained in Stroop Test and in some TOL DX sub-scores support that an underlying attention deficit is present in PD-MCI patients.…”

Section: Discussionmentioning

confidence: 87%

Conscious Attention Defect and Inhibitory Control Deficit in Parkinson’s Disease-Mild Cognitive Impairment: A Comparison Study With Amnestic Mild Cognitive Impairment Multiple Domain

Cammisuli

Sportiello²

2017

Psychiat Danub

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“…Several risk factors have previously been identified, including chronological age, akinetic-rigid motor features, rapid eye movement sleep behavior disorder, and orthostatic blood pressure [5,6,7]. There are also several features of cognitive impairment that predict future dementia progression in PD patients, including deficits in semantic fluency, visuospatial, executive, and memory function tests [7,8]. …”

Section: Introductionmentioning

confidence: 99%

Dementia-Predicting Cognitive Risk Score and Its Correlation with Cortical Thickness in Parkinson Disease

Jeon

Ham

et al. 2017

Dement Geriatr Cogn Disord

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Background: We developed a risk score system to predict risks of developing dementia in individual Parkinson disease (PD) patients using baseline neuropsychological tests. Methods: A total of 216 nondemented PD patients underwent a baseline neuropsychological evaluation and were followed up for a mean of 2.7 (±1.1) years. Univariate Cox regression models controlled for age, gender, and education selected neuropsychological tests individually predicting dementia risk. Then, a multivariate Cox regression model combined them into a cognitive risk score system. Cortical areas correlating with cognitive risk score were investigated using a separate MRI data set from 207 nondemented PD patients. Results: Fifty-two patients (23.9%) developed dementia. The univariate Cox regression analyses identified the confrontational naming and semantic fluency tests, frontal/executive function tests, immediate verbal memory test, and visuospatial function test as predicting dementia risk. The calculated cognitive risk score (range 53-188) predicted future dementia with moderate accuracy (integrated area under the curve = 0.79; 95% CI: 0.73-0.85). A higher cognitive risk score correlated with cortical thinning in the right anteromedial temporal cortex, bilateral posterior cingulate cortex, right anterior cingulate cortex, left parahippocampal gyrus, and right superior frontal cortex in a separate MRI data set. Conclusion: The cognitive risk score system is a useful approach to predict the dementia risk among PD patients.

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Exploratory analysis of neuropsychological and neuroanatomical correlates of progressive mild cognitive impairment in Parkinson's disease

Cited by 127 publications

References 53 publications

Different Functional and Microstructural Changes Depending on Duration of Mild Cognitive Impairment in Parkinson Disease

Different Functional and Microstructural Changes Depending on Duration of Mild Cognitive Impairment in Parkinson Disease

Conscious Attention Defect and Inhibitory Control Deficit in Parkinson’s Disease-Mild Cognitive Impairment: A Comparison Study With Amnestic Mild Cognitive Impairment Multiple Domain

Dementia-Predicting Cognitive Risk Score and Its Correlation with Cortical Thickness in Parkinson Disease

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