Exploratory, Phase II Controlled Trial of Shiunko Ointment Local Application Twice a Day for 4 Weeks in Ethiopian Patients with Localized Cutaneous Leishmaniasis

Na‐Bangchang, Kesara; Ahmed, O.H.; Hussein, Jemal; Hirayama, Kenji; Kongjam, Panida; Aseffa, Abraham; Karbwang, Juntra

doi:10.1155/2016/5984709

Cited by 9 publications

(13 citation statements)

References 17 publications

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“…Mechanism studies revealed that Shiunko promoted the epithelization, angiogenesis, and granulation tissue formation of wounds ( Huang et al, 2004 ; Lu et al, 2008 ; Chak et al, 2013 ). Recently, clinical trials proved that Shiunko might be also effective for radiation-induced dermatitis in patients with breast cancer and localized cutaneous leishmaniasis ( Na-Bangchang et al, 2016 ; Kim et al, 2021 ). NF3, a two-botanical drug formulation comprised Astragali radix and Rehmanniae radix, is another one which has been extensively investigated for the treatment of diabetic foot ulcer ( Lau et al, 2008 ; Lau et al, 2009a ; Zhang et al, 2011 ; Lau et al, 2012 ).…”

Section: Multiherbal Preparations With Wound Healing Propertiesmentioning

confidence: 99%

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

et al. 2022

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Chronic and unhealed wound is a serious public problem, which brings severe economic burdens and psychological pressure to patients. Various botanical drugs in traditional Chinese medicine have been used for the treatment of wounds since ancient time. Nowadays, multiple wound healing therapeutics derived from botanical drugs are commercially available worldwide. An increasing number of investigations have been conducted to elucidate the wound healing activities and the potential mechanisms of botanical drugs in recent years. The aim of this review is to summarize the botanical drugs in traditional Chinese medicine with wound healing properties and the underlying mechanisms of them, which can contribute to the research of wound healing and drug development. Taken together, five botanical drugs that have been developed into commercially available products, and 24 botanical drugs with excellent wound healing activities and several multiherbal preparations are reviewed in this article.

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Section: Multiherbal Preparations With Wound Healing Propertiesmentioning

confidence: 99%

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

et al. 2022

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“…Three small clinical trials have been done so far. The only placebo-controlled trial was done on LCL patients using a Chinese medical ointment called Shiunko [96], which was not better than placebo, with cure rates of 20% (4/20) and 25% (5/20) respectively. Two small clinical trials were done over 20 years ago, using rifampicine with amithiozone versus pentamidine (LCL only) [97] and itraconazole versus placebo (10 LCL and 4 DCL) [98], of which only all six patients treated with pentamidine and two treated with placebo clinically improved.…”

Section: Treatmentmentioning

confidence: 99%

Cutaneous Leishmaniasis Due to Leishmania aethiopica

et al. 2018

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Leishmania aethiopica is the main causative species for cutaneous leishmaniasis (CL) in Ethiopia. Despite its considerable burden, L. aethiopica has been one of the most neglected Leishmania species. In this review, published evidence on L. aethiopica history, geography, vector, reservoir, epidemiology, parasitology, and immunology is discussed and knowledge gaps are outlined. L. aethiopica endemic regions are limited to the highland areas, although nationwide studies on CL prevalence are lacking. Phlebotomus pedifer and P. longipes are the sandfly vectors and hyraxes are considered to be the main reservoir, but the role of other sandfly species and other potential reservoirs requires further investigation. Where and how transmission occurs exactly are also still unknown. Most CL patients in Ethiopia are children and young adults. Lesions are most commonly on the face, in contrast to CL caused by other Leishmania species which may more frequently affect other body parts. CL lesions caused by L. aethiopica seem atypical and more severe in their presentation as compared to other Leishmania species. Mucocutaneous leishmaniasis and diffuse cutaneous leishmaniasis are relatively common, and healing of lesions caused by L. aethiopica seems to take longer than that of other species. A thorough documentation of the natural evolution of L. aethiopica as well as in depth studies into the immunological and parasitological characteristics that underpin the atypical and severe clinical presentation are needed. Better understanding of CL caused by this parasite species will contribute to interventions related to transmission, prevention, and treatment.

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“…A total of 808 study subjects participated in the 22 studies [ 8 – 11 , 13 – 18 , 25 – 36 ]. Twelve studies (nine case series [ 8 , 9 , 25 – 27 , 29 , 30 , 32 , 33 ] and three case reports [ 10 , 11 , 35 ]) documented treatment outcomes as part of routine clinical practice.…”

Section: Resultsmentioning

confidence: 99%

Treatment outcomes of cutaneous leishmaniasis due to Leishmania aethiopica: A systematic review and meta-analysis

Alemu,

Derseh,

Kaba

et al. 2023

PLoS ONE

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Background Leishmania aethiopica is a unique species that causes cutaneous leishmaniasis (CL), and studies evaluating treatment outcomes for this condition reported inconsistent findings. This study aimed to summarize the evidence on treatment outcomes of CL caused by L. aethiopica to support decisions or propose further study. Methods We searched PubMed, Scopus, and ScienceDirect. In addition, we searched grey literature on Google Scholar and performed manual searching on the reference list of articles. Two authors did the screening, selection, critical appraisal, and data extraction. With the narrative synthesis of evidence, we performed a random effects model meta-analysis using the metaprop package in Stata 17. We did sensitivity and subgroup analyses after assessing heterogeneity using the I-squared test and forest plots. The funnel plot and Egger’s test were used to assess publication bias. Results The review included 22 studies with 808 participants, and the meta-analysis included seven studies with 677 participants. Most studies documented treatment outcomes with antimonial monotherapy, and only one study reported outcomes with combination therapy. The overall pooled proportion of cure was 63% (95% CI: 38–86%). In the subgroup analysis, systemic antimonial monotherapy showed a cure rate of 61%, and the proportion of cure was 87% with topical therapy. Topical therapy showed a better cure for the localized clinical phenotype. A cohort study documented a cure rate of 94.8% with combination therapy for the localized, mucocutaneous, and diffuse clinical phenotypes. The pooled proportion of unfavourable outcomes was partial response (19%), relapse (17%), discontinuation (19%), and unresponsiveness (6%). Conclusions The pooled proportion of cure is low with antimonial monotherapy. Despite limited evidence, combination therapies are a promising treatment option for all clinical phenotypes of CL caused by L. aethiopica. Future high-quality randomized control trials are needed to identify effective monotherapies and evaluate the effectiveness of combination therapies.

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Exploratory, Phase II Controlled Trial of Shiunko Ointment Local Application Twice a Day for 4 Weeks in Ethiopian Patients with Localized Cutaneous Leishmaniasis

Cited by 9 publications

References 17 publications

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

Cutaneous Leishmaniasis Due to Leishmania aethiopica

Treatment outcomes of cutaneous leishmaniasis due to Leishmania aethiopica: A systematic review and meta-analysis

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