The entrepreneurial ecosystem is currently emerging as a major topic for researchers. An important question in entrepreneurship research, about how ecosystems can contribute in creating entrepreneurs and the sustainability of their businesses in the future. This article was written using a systematic literature review method that analyzed 60 conceptual and empirical articles. Sequenced 1005 documents sourced from ScienceDirect to explore, analyze, and discuss the contribution of the entrepreneurial ecosystem in the literature on the topic of sustainable entrepreneurship. This literature review classifies six keyword clusters of entrepreneurship ecosystem: entrepreneurship and entrepreneurship ecosystem, entrepreneurship education ecosystem, entrepreneurial university, entrepreneurship learning innovation, digital entrepreneurship, and business ecosystem. Where the entrepreneurship education ecosystem and entrepreneurship university are important ecosystems in the beginning of entrepreneurial sustainability. We suggest the existence of learning innovations in entrepreneurship education to support the achievement of sustainable entrepreneurship and link it to the business ecosystem of service companies, trade, and industry.