With the increase of the incidence rate of digestive system diseases, digestive endoscopy has become an essential measure. The nursing quality of digestive endoscopy room will have a direct impact on the examination results and treatment effect, so improving the nursing quality of digestive endoscopy room has always been the focus of attention. In this paper, the smart electronic medical blockchain technology and hospital standardized nursing management mode are combined to develop the smart medical standardized nursing management mode. Firstly, 88 patients with digestive endoscopy in a hospital from October 2018 to October 2019 were selected as the experimental subjects: 44 cases in the control group and 44 cases in the experimental group. The control group implemented the traditional management mode of digestive endoscopy room, and the experimental group implemented the standardized nursing management mode of smart medicine. The blood pressure level before and after nursing and the probability of adverse reactions in the process of nursing were counted. After nursing, the patients were asked to fill in the nursing satisfaction questionnaire, evaluate the nursing quality of nursing staff, and make statistics and comparison on the occurrence of safety events in digestive endoscopy room. After nursing, the systolic pressure drop of the experimental group was 125.36 ± 7.27 mmhg, diastolic pressure drop was 73.24 ± 4.21 mmhg, and the incidence of adverse reactions was 11.36%. The satisfaction rate of the experimental group was 15%, 29.55%, and 22.73% higher than that of the control group. The average scores of nursing skills, operation level, and examination results of nursing staff in the experimental group were 94.49, 95.12, and 95.89, respectively; the qualified rate of disinfection of digestive endoscopy room in the experimental group was 100%, the degree of cooperation between doctors and nurses was 100%, the timely rate of emergency measures was 95.45%, and the incidence of accidents was 0%. This shows that, under the standardized nursing of smart medicine, the blood pressure of patients is more stable, the incidence of adverse reactions is lower, the nursing satisfaction is higher, and the nursing quality of nursing staff and the safety of digestive endoscopy room are also improved.