Exploring the Reasons for Delay in Treatment of Oral Cancer

Peacock, Zachary S.; Pogrel, M. Anthony; Schmidt, Brian L.

doi:10.14219/jada.archive.2008.0046

Cited by 118 publications

(117 citation statements)

References 46 publications

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“…As per World Health Organization report oral cancer is having one of the highest mortality ratios amongst other malignancies with a death rate at 5 years from diagnosis at 45 % [11]. This high morbidity rate is attributed to the late diagnosis of the disease [12]. Because of lack in national screening programs together with a lack of definitive and satisfactory biological markers [13] for early oral cancer detection has resulted in late stage diagnosis of oral cancer.…”

Section: Discussionmentioning

confidence: 99%

Protein Thiols and Butryrylcholinestrase in Saliva of Oral Cancer Patients

et al. 2013

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Oral squamous cell carcinoma is one of the most common malignancies recognized. Biomarkers which can predict presence of cancer and its progression can help in better management of these disorders. Over production of lipid peroxidation byproducts and disturbances in antioxidant defense system have been implicated in the pathogenesis of several diseases including oral cancer. Studies have shown a correlation of butyrylcholinesterase (BChE), with tumourigenesis, cell proliferation and cell differentiation. Earlier we have observed a significant elevation in plasma BChE and protein thiols in oral cancer patients which correlated well with stages of cancer. As it was not clear whether the above markers will be altered in saliva of oral cancer patients this study was undertaken. Institutional Ethics Committee gave permission to carry out this study. Total of 55 subjects comprising healthy controls (n = 30) and biopsy proven oral cancer patients (n = 25) consented to participate in this study. Salivary samples from cases were taken before any definitive treatment. Protein thiols and BChE were estimated in salivary samples using validated assay methods. Oral cancer patients had a significant increase in pre-treatment salivary BChE levels (p B 0.001) and a significant decrease (p B 0.001) in salivary thiols as compared to respective values in controls. Salivary protein thiols and BChE may have a role in pathophysiology of oral cancer. Saliva can be used as a potential non-invasive screening tool in oral cancer patients.

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Section: Discussionmentioning

confidence: 99%

Protein Thiols and Butryrylcholinestrase in Saliva of Oral Cancer Patients

et al. 2013

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“…3 Studies have demonstrated that good positive predictive values can be achieved by oral cancer tissue staining with toluidine blue. 4,5 However, extensive experience is required in applying this technique and in interpreting its results. Exfoliative cytology may be a less invasive method for oral cancer detection 6 but exfoliated cancer cells tend to correlate with tumor burden and lower rates of detection are seen in those with minimal or early disease.…”

Section: Current Scenario In Oral Cancer Screeningmentioning

confidence: 99%

Utilization of Saliva as a Diagnostic Fluid in Determination of Oral Cancer

Vahanwala¹,

Mukherji²

2014

International Journal of Head and Neck Surgery

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Today's world technology has evolved and we have been able to evaluate certain phenomenon that occurs before manifestation of observable clinical symptoms. Every health care worker has a dream of a perfect diagnosis so that correct service whether medical or surgical, care can be facilitated to the patient. Cancer is one such disease where tracking the tell-tale signs is essential. The one factor behind oral cancer's high mortality is the challenge in its early detection. Despite the scepticism in the scientifi c community and the conservatism of the patients, saliva seems to emerge as a valuable tool in cancer diagnostics and mass screening of the population. An attempt to integrate the simultaneous testing of different salivary molecular markers in order to raise the possibility of an accurate diagnosis by simply using micro-and nanoelectricmechanical systems biosensors is on the way raising much hope in its future applications.

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“…Despite advances in diagnostic procedures in medical practice, mortality of OSCC has remained unchanged in the past 40 years and and a significant diagnostic delay (up to 8 months)has persisted over time. (Abdo et al 2007;Peacock, Pogrel, and Schmidt 2008) For example, the mortality rate for oral cancer is similar to that of colon cancer even though it is much easier to screen and detect oral cancers than it is for colon cancer. The most important factor in patient survival and prognosis is early diagnosis.…”

Section: Introductionmentioning

confidence: 99%