Exploring the unexplored avenues of surface charge in nano-medicine

Instigation of the epoch of nanovaccines in cancer immunotherapy

“…Liposomes are susceptible to enzymatic degradation in the liver which diminishes the sustained effect and therapeutic efficacy of nanovaccines (Mahjub et al, 2018). In such cases, employment of lipid polymer hybrids could impart stability, controlled release and sustained immunostimulation circumventing the drawbacks of conventional liposomes (Raemdonck et al, 2014; Shah et al, 2021). Recently, Su et al prepared cationic polymer–lipid hybrid liposomes as carriers for delivering anionic antigen epitopes such as toll‐like receptor‐9 agonist (TLR9), CpG (AE/CpG), indoleamine‐2,3‐dioxygenase (IDO) inhibitor, and 1‐methyl‐tryptophan (1‐MT), to enhance their immunogenicity potential.…”

“…render them suitable drug delivery agents. The predominant difference between inorganic nanoparticles and other delivery systems lies in the foundation of the protein corona around the nanoparticle interface (Shah et al, 2021). Fogli and colleagues employed the formation of cancer cell lysate corona over the nanoparticulate surface to boost the immunogenic potential.…”

Density functional theory computation of the intermolecular interactions of Al2@C24and Al2@Mg12O12semiconducting quantum dots conjugated with the glycine tripeptide

“…16 Similarly, they play a decisive role in the eld of pharmacology, ranging from drug discovery to the investigation of drug-receptor coupling. [17][18][19][20][21] The majority of scientists have paid a great deal of attention to the consequences of these classical intermolecular interactions. 7,8,11,12,[17][18][19]22,23 From the perspective of cellular level, several research groups have carried out their study with reference to the eld of nanomedicine, specically the interactions of nanostructures, or quantum dots, with cells, biomolecules, and proteins.…”

“…16 Similarly, they play a decisive role in the field of pharmacology, ranging from drug discovery to the investigation of drug-receptor coupling. 17–21 The majority of scientists have paid a great deal of attention to the consequences of these classical intermolecular interactions. 7,8,11,12,17–19,22,23…”

Synergistic size and charge conversions of functionalized PAMAM dendrimers under the acidic tumor microenvironment

“…16 It has been inferred that a neutral or negative surface of nano-therapeutic systems could prevent non-specific protein adsorption to prolong blood circulation, while a positively charged surface is beneficial to activating endocytosis. 17,18 Based on the slight acidity (pH ∼ 6.2-7.0) of the tumor microenvironment (TME) due to the Warburg effect, 19 several pH-responsive charge-reversal systems have been developed, such as cationic exposure via acid-cleavable units and the protonation of weak basic groups. 20,21 These systems require hydrophilic polymers, such as polyethylene glycol (PEG), to ensure their structural stability in circulation.…”