Exploring urinary biomarkers to assess oxidative DNA damage resulting from BTEX exposure in street children

Rafiee, Ata; Delgado-Saborit, Juana María; Sly, Peter D.; Amiri, Hoda; Hoseini, Mohammad

doi:10.1016/j.envres.2021.111725

Cited by 16 publications

(3 citation statements)

References 96 publications

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“…We report that the detection level of different BTEX metabolites was different due to variations in the absorption, metabolism, and distribution of these compounds 42 . Our study results showed that the control group was exposed to higher concentrations of BTEX, contrasted with workers in past investigations in various occupational and environmental exposures 9 , 41 , 43 , 44 .…”

Section: Discussioncontrasting

confidence: 87%

Exposure assessment of wastewater treatment plant employees to BTEX: a biological monitoring approach

Dehghani

Abbasi

Taherzadeh

et al. 2022

Sci Rep

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To monitor employees' work safety and exposure against air contaminants, Trans, trans-muconic acid, Hippuric acid, Methyl hippuric acid, Mandelic acid and Phenylglyoxylic acid can be used as reliable biomarkers of exposure to benzene, toluene, ethylbenzene, and xylene (BTEX) compounds. This study aims to determine the level of urinary metabolites of BTEX compounds using biological monitoring in the employees of a wastewater treatment plant (WWTP) in the south of Iran. The study was performed on 56 employees of the WWTP of one of the southern cities of Iran in 2020. Urine samples (n total = 112) consisting of 60 samples of employees working in the operation section (exposed group) and 52 samples of employees working in the administrative section (control group) in the WWTP were collected before and at the end of their shift. The mean concentration of urinary metabolites of BTEX of both groups ranged from 546.43 (μg/g cr) for trans, trans-muconic acid to 0.006 (μg/g cr) for methyl hippuric acid, which indicates that most of the evaluated metabolites showed a higher concentration than their occupational threshold limit value urine (p < 0.05). Regression analysis results showed a significant correlation (p < 0.05) between age and utilization of flame heaters with changes in the measured BTEX metabolites in the urine. The results of this study illustrate that WWTPs should be considered as one of the workplaces with potential sources of BTEX exposure for employees. Future investigations are recommended to perform itemized appraisals of BTEX intake sources, particularly in employees of the operational sections of WWTP.

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Section: Discussioncontrasting

confidence: 87%

Exposure assessment of wastewater treatment plant employees to BTEX: a biological monitoring approach

Dehghani

Abbasi

Taherzadeh

et al. 2022

Sci Rep

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“…These results were in agreement with those of another study conducted on Korean adults and children (Yoon et al 2012 ). In one other research carried out in Tehran, the MDA concentrations in the exposed and non-exposed samples were respectively 1.87- and 2.58-folds lower compared to the children aged 7–13 years working as street flower sellers (Rafiee et al 2022 ). Moreover, the levels of MDA measured in the exposed and non-exposed groups were 17–80- and 23–108-folds lower than those measured in a group of children and their mothers living in Korea and China (Lee et al 2004 ).…”

Section: Discussionmentioning

confidence: 87%

Exposure assessment of children living in homes with hookah smoking parents to polycyclic aromatic hydrocarbons: urinary level, exposure predictors, and risk assessment

Tabatabaei

Shamsedini

Mohammadpour

et al. 2022

Environ Sci Pollut Res

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Children are extremely liable to indoor air pollutants as their physiology and a few metabolic pathways are different from those of adults. The present cross-sectional study aimed to assess exposure of children living with parents who use hookah tobacco smoke to polycyclic aromatic hydrocarbons (PAHs) using a biomonitoring approach. The study was conducted on 25 children (7–13 years of age) exposed to hookah smoke at home and 25 unexposed age-matched children. Urinary levels of five metabolites of PAHs were quantified via headspace gas chromatography-mass spectrometry (GC–MS). Urinary malondialdehyde (MDA) was measured, as well. Information regarding the sociodemographic and lifestyle conditions was collected through interviews using managed questionnaires. The urinary 1-OH-NaP and 9-OH-Phe concentrations were respectively 1.7- and 4.6-folds higher in the case samples compared to the control group ( p < 0.05). In addition, urinary MDA levels were 1.4 times higher in the exposed children than in the unexposed group, but the difference was not statistically significant ( p > 0.05). Increasing the consumption of grilled and meat food in the diet increased the participants’ urinary 2-OH-Flu and 1-OH-Pyr levels, respectively. Moreover, sleeping in the living room instead of the bedroom at night was a significant predictor of high 1-OH-NaP and 2-OH-NaP concentrations in the children’s urine. Overall, the findings confirmed that children living in their homes with hookah-smoking parents were significantly exposed to naphthalene and phenanthrene. Hence, implementing protective measures is critical to reduce the exposure of this group of children. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-022-20589-0.

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“…Children are highly susceptible to environmental contaminants as their physiology and some metabolic pathways differ from those of adults. Street children, working at busy intersections, are significantly exposed to chemical solvents that are associated with oxidative stress [1].…”

Section: Introductionmentioning

confidence: 99%

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2022

Journal of Pharmacology and Drug Metabolism

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It is very important to identify and control risk factors of Covid-19 in susceptible subjects for successful treatment and prevention. Both voluntary and involuntary toxic solvent inhalations are becoming an increasing concern in the Covid-19 pandemic, with possible interactions of toxic solvents exposure and covid-19 drugs treatment or synergic effects on oxidative damage parameters within tissues of young or adults vulnerable. These toxic chemicals induce oxidative stress in the skin and other tissues as well as DNA damage, inflammation, skin barrier dysfunction and immune dysregulation; thus, increasing the sensibility of this population.

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Exploring urinary biomarkers to assess oxidative DNA damage resulting from BTEX exposure in street children

Cited by 16 publications

References 96 publications

Exposure assessment of wastewater treatment plant employees to BTEX: a biological monitoring approach

Exposure assessment of wastewater treatment plant employees to BTEX: a biological monitoring approach

Exposure assessment of children living in homes with hookah smoking parents to polycyclic aromatic hydrocarbons: urinary level, exposure predictors, and risk assessment

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