Exposure and health risk assessment of applicators to DDT during indoor residual spraying in malaria vector control program

Wassie, Fantahun; Spanoghe, Pieter; Tessema, Dejene A.; Steurbaut, Walter

doi:10.1038/jes.2012.45

Cited by 15 publications

(7 citation statements)

References 29 publications

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“…Recent studies suggest elevated plasma levels of DDT and DDE among workers who apply DDT during indoor residual spraying (IRS), as well as among residents in areas where IRS takes place, compared with levels from the general population (Channa et al 2012; de Jager et al 2009; Ritter et al 2011; Wassie et al 2012). Despite evidence of potential harmful human health effects of DDT exposure, there remains a gap in knowledge regarding determinants and strategies for reduction of exposure, particularly among nonoccupationally exposed individuals (i.e., residents of IRS-treated homes).…”

Section: Introductionmentioning

confidence: 99%

Predictors of Plasma DDT and DDE Concentrations among Women Exposed to Indoor Residual Spraying for Malaria Control in the South African Study of Women and Babies (SOWB)

Whitworth

Bornman

Archer

et al. 2014

Environ Health Perspect

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Background: Few studies have examined predictors of DDT (dichlorodiphenyltrichloroethane) and DDE (dichlorodiphenyldichloroethylene) levels among residents in homes sprayed with DDT for malaria control with the aim of identifying exposure-reduction strategies.Methods: The present analysis included 381 women enrolled in the Study of Women and Babies (SOWB) during 2010–2011, from eight South African villages in the Limpopo Province, South Africa. Indoor residual spraying (IRS) occurred in half of the villages. Questionnaires regarding various demographic and medical factors were administered and blood samples were obtained. We classified the women into three exposure groups by type of residence: unsprayed village (n = 175), IRS village in household with a low likelihood of DDT use (non-DDT IRS household, n = 106), IRS village in household with a high likelihood of DDT use (DDT IRS household, n = 100). We used multivariable models of natural log-transformed DDT plasma levels (in micrograms per liter) and DDE (in micrograms per liter) to identify predictors for each group.Results: Median levels of DDT and DDE among women in unsprayed villages were 0.3 [interquartile range (IQR): 0.1–0.9] and 1.7 (IQR: 0.7–5.5), respectively. Median levels of DDT and DDE among women in DDT IRS households were 2.6 (IQR: 1.1–6.6) and 8.5 (IQR: 4.7–18.0), respectively. In unsprayed villages, women with water piped to the yard, rather than a public tap, had 73% lower DDT (95% CI: –83, –57%) and 61% lower DDE (95% CI: –74, –40%) levels. In DDT IRS households, women who reported taking more than six actions to prepare their home before IRS (e.g., covering water and food) had 40% lower DDT levels (95% CI: –63, –0.3%) than women who took fewer than four actions.Conclusion: The predictors of DDT and DDE plasma levels identified in the present study may inform interventions aimed at decreasing exposure. Among households where DDT is likely to be used for IRS, education regarding home preparations may provide an interventional target.Citation: Whitworth KW, Bornman RM, Archer JI, Kudumu MO, Travlos GS, Wilson RE, Longnecker MP. 2014. Predictors of plasma DDT and DDE concentrations among women exposed to indoor residual spraying for malaria control in the South African Study of Women and Babies (SOWB). Environ Health Perspect 122:545–552; http://dx.doi.org/10.1289/ehp.1307025

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Section: Introductionmentioning

confidence: 99%

Predictors of Plasma DDT and DDE Concentrations among Women Exposed to Indoor Residual Spraying for Malaria Control in the South African Study of Women and Babies (SOWB)

Whitworth

Bornman

Archer

et al. 2014

Environ Health Perspect

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“…The authors found that for shortterm exposures, the estimates were acceptable in comparison to the measurements; however, for long-term exposure the simulation tools were less accurate (Park et al 2018). Another study of the exposure to DDT from indoor residual spraying in a malaria vector control programme showed a large underestimation in the ConsExpo 5.1 b01 simulated exposure (Wassie, Spanoghe, Tessema, Steurbaut 2012). However, the specific parameters entered in the ConsExpo simulation tool was not described in detail.…”

Section: Simulations Of Exposure Concentrations In Consexpo Web and Cmentioning

confidence: 99%

Biocidal spray product exposure: Measured gas, particle, and surface concentrations compared with spray model simulations

Clausen

Mørck

Jensen

et al. 2019

Journal of Occupational and Environmental Hygiene

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“…농작업자의 농약 사용 시 노출의 주요 경로는 피부노출과 호흡노출이다 (Fenske and Day JR, 2005;Hughes et al, 2008;Chester, 2010;Behroozy, 2013). 피부노출 측정은 주 로 패치법(patch)을 사용해 왔으며 (Chester, 1993;Fenske, 1993;Soutar et al, 2000;Chester, 2010;Farahat et al, 2010;Wassie et al, 2012;Behroozy, 2013;Abukari, 2015;An et al, 2015;Zhao et al, 2015) 대부분의 국내 노출 연 구 또한 패치법을 주로 이용하였다 (Liu, 2003;Kang et al, 2004;Choi et al, 2006; a ; Kim et al, 2012 a,b ;Choi and Moon, 2013;Kim et al, 2013;Choi, 2014). 패치법은 사용하기 편리하고 경제적 이지만 작은 면적의 패치를 실제 체표면적으로 외삽하는 과 정에서 과대, 과소평가되는 경향이 있고, 실제 작업복과 재 질 차이로 인하여 농약의 흡착 정도가 달라 정확한 노출량 을 측정하기 어려운 단점이 있다 (Franklin et al, 1981;Fenske, 1990;Niven et al, 1993;Tannahill et al, 1996;Cao et al, 2015).…”

Section: 서 론unclassified

Evaluation for Application of IOM Sampler for Agricultural Farmer's Inhalation Exposure to Kresoxim-methyl and Fenthion

Lee¹,

Kim²,

Lee³

et al. 2015

The Korean Journal of Pesticide Science

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An IOM sampler equipped with glass fiber filter has been recently utilized instead of solid adsorbent, which was used to measure the inhalation exposure of agricultural operator to pesticides. The aim of this study is to validate the efficacy of an IOM sampler by measuring the trapping efficiency and breakthrough using kresoxim-methyl water-dispersible granule and fenthion emulsifiable concentrate. On LC-MS/MS, minimum detection level was 12.5 pg and method limit of detection was 5.0 ng/mL. Good linearity (R 2 > 0.999) for matrix matched standards was obtained. Recoveries of pesticides from glass fiber filter were 102-109% (kresoxim-methyl) and 97-104% (fenthion) while those from XAD-2 resin were 94-98% (kresoxim methyl) and 93-100% (fenthion). Trapping efficiency test was performed with personal air pumps and IOM sampler (glass fiber filter) connected with solid adsorbent (XAD-2 resin) with two types of formulation (solid and liquid) which were diluted by standard rate and sprayed to IOM sampler. Those pesticides were trapped only in glass fiber filter without any breakthrough to solid adsorbent. After spiking of pesticides to glass fiber filter, breakthrough test was carried out with IOM sampler (glass fiber filter) which was connected with solid adsorbent. As a results, 87-101% of kresoxim-methyl and 96-105% of fenthion remained in spiked glass fiber filter, however, no pesticides were detected in second glass fiber filter and solid adsorbent. In conclusion, IOM sampler which equipped with glass fiber filter can be applied widely for pesticide inhalation exposure study since it has good trapping efficiency and adsorption capacity, regardless of the solid or liquid formulation.

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Exposure and health risk assessment of applicators to DDT during indoor residual spraying in malaria vector control program

Cited by 15 publications

References 29 publications

Predictors of Plasma DDT and DDE Concentrations among Women Exposed to Indoor Residual Spraying for Malaria Control in the South African Study of Women and Babies (SOWB)

Predictors of Plasma DDT and DDE Concentrations among Women Exposed to Indoor Residual Spraying for Malaria Control in the South African Study of Women and Babies (SOWB)

Biocidal spray product exposure: Measured gas, particle, and surface concentrations compared with spray model simulations

Evaluation for Application of IOM Sampler for Agricultural Farmer's Inhalation Exposure to Kresoxim-methyl and Fenthion

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