Exposure to benzophenones, parabens and triclosan among pregnant women in different trimesters

Zhao, Hongzhi; Huo, Wenqian; Li, Jiufeng; Ma, Xiaofeng; Xia, Wei; Pang, Zhengji; Xie, Mingyi; Xu, Shunqing; Cai, Zongwei

doi:10.1016/j.scitotenv.2017.07.003

Cited by 35 publications

(14 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BP-3 with the highest concentration was predominant among other metabolites in the 1st and 3rd trimesters, which is in line with the findings of other studies (Gao et al 2015;Zhao et al 2017;Long et al 2019). This is reasonable because the study area is located in the center of Iran with a warm and desert climate and intense sunlight with a high Fig.…”

Section: Discussionsupporting

confidence: 91%

“…A high detection rate of the studied BP derivatives in the mothers' urine in this research was achieved, compared to other studies conducted in China (Jiang et al 2019;Chen et al 2021), which could be attributed to the high sensitivity of our analytical method and reaching very low LOD for these metabolites. Even in many studies of maternal exposure to BP derivatives, the concentration of BP-8 has not been evaluated, or its detection rate was very low, around 13% (Song et al 2020) and 2% (Zhao et al 2017). A high median concentration of BP-8 in the 1st and 3rd trimesters of pregnancy (1.1-1.9 µg/L) in the present study was detected compared to the concentration < 0.001 µg/L in the mentioned studies.…”

Section: Discussioncontrasting

confidence: 82%

See 1 more Smart Citation

The association of prenatal exposure to benzophenones with gestational age and offspring size at birth

Teiri

Samaei

Dehghani

et al. 2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

In recent decades, emerging environmental pollutants such as endocrine-disrupting chemicals (EDCs) have become a particular concern. This study examined the association of maternal exposure to benzophenones as one of the EDCs with gestational age and evaluated their effects on birth outcomes including birth weight, birth length, head circumference, and Ponderal Index. We assessed 166 pregnant mothers of the PERSIAN cohort population of Isfahan, Iran, in the 1st and 3rd trimesters of pregnancy and their infants at birth. Four common benzophenones (BPs) including 2,4-dihydroxy benzophenone (BP-1), 2-hydroxy-4-methoxy benzophenone (BP-3), 4-hydroxy benzophenone (4-OH-BP), and 2,2′-dihydroxy-4-methoxy benzophenone (BP-8) were measured in maternal urine samples. The median urinary concentrations of 4-OH-BP, BP-3, BP-1, and BP-8 in the 1st trimester were 6.62, 7.5, 4.39, and 1.32 µg/g creatinine and those in the 3rd trimester were 3.15, 16.98, 9.95, and 1.04 µg/g creatinine, respectively. BP-3 was the predominant metabolite in both trimesters. There was a significant correlation between BP-3, BP-1, and 4-OH-BP levels (p < 0.05) but not BP-8. BP-1 showed a significant positive association with gestational age (GA) in all infants in the 1st trimester, but a negative association was observed between BP-3 and BP-1 levels and GA in girls. Classification of infants' birth weight for different GAs represented that the majority of them were appropriate for GA. However, boys' weights were heavier than girls. Also, birth outcomes of preterm (< 37 weeks) infants were noticeably lower than term infants (37-42 weeks). This study demonstrated that benzophenone derivatives especially BP-3 can affect the duration of pregnancy and consequently fetal growth in the early and late stages of pregnancy. This is more pronounced in girls; however, more investigations in a different population are needed to prove the results. Therefore, the application of these compounds as a UV protector requires precise regulation to reduce exposure, especially in pregnant women.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 82%

The association of prenatal exposure to benzophenones with gestational age and offspring size at birth

Teiri

Samaei

Dehghani

et al. 2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…Concentrations in our cohort were low relative to those measured in other cohorts such as the PROTECT and LIFECODES studies (Meeker et al 2013; Ferguson et al 2017) (Table 3). However, the concentrations of benzophenone-3 were much higher compared with those measured in a Chinese cohort of pregnant women (Zhao et al 2017). It is possible that as the half-life of benzophenone-3 is only a few hours, and we collected urine on admission to delivery room, our benzophenone-3 results were affected by unique behavior of a select group of patients and do not represent the exposure in the general Israeli population.…”

Section: Discussionmentioning

confidence: 55%

Urinary concentrations of phthalate metabolites, bisphenols and personal care product chemical biomarkers in pregnant women in Israel

Machtinger

Berman

Adir

et al. 2018

Environment International

View full text Add to dashboard Cite

Mounting evidence suggests possible adverse effects of intrauterine exposure to certain phenols and phthalates, two classes of endocrine disruptor chemicals, on the developing fetus, with consequences into later life. These findings have contributed to the replacement of some chemicals, such as di‑2‑ethylhexyl phthalate (DEHP) and bisphenol A (BPA), in consumer products. For the current study we quantified urinary concentrations of biomarkers of exposure among 50 pregnant women in Israel to several phthalates, bisphenols and personal care product chemicals, as well as DEHP and BPA alternatives. We detected 14 of the 31 biomarkers in more than 90% of the women. We detected biomarkers of 1,2‑cyclohexane dicarboxylic acid, diisononyl ester (DINCH), bisphenol S, and bisphenol F not as frequently (27-56%). This study is the first to evaluate exposure to triclosan, bisphenols, parabens, and phthalates and BPA alternatives among Israeli pregnant women.

show abstract

“…A number of emerging epidemiological studies in the human report paraben esters in pregnancy‐associated matrices such as amniotic fluid, maternal blood, fetal cord blood, and placental tissue, 32–34 suggesting the potential for transplacental transfer and prenatal exposure to parabens. Reports have also revealed the adverse impact on the programming of emotional neurobehavioral brain circuits due to early life exposure to environmental contaminants 35,36 .…”

Section: Introductionmentioning

confidence: 99%

Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae

Lite

Guru

Juliet

et al. 2022

Environmental Toxicology

View full text Add to dashboard Cite

Parabens are synthetic antimicrobial compounds used as a preservative for extending the shelf life of food, pharmaceutical and cosmetic products. The alkyl chain length of the paraben esters positively correlates with their antimicrobial property. Hence, long-chain paraben esters, namely butylparaben and propylparaben, are used in combination as they have better solubility and antimicrobial efficacy. Extensive use of parabens has now resulted in the ubiquitous presence of these compounds in various human and environmental matrices. During early life, exposure to environmental contaminants is known to cause oxidative-stress mediated apoptosis in developing organs. The brain being one of the high oxygen-consuming, metabolically active and lipid-rich organ, it is primarily susceptible to reactive oxygen species (ROS) and lipid peroxidation (LP) induced neuronal cell death. The primary cause for the impairment in cognitive and emotional neurobehvioural outcomes in neurodegenerative disease was found to be associated with neuronal apoptosis. The present study aimed to study butylparaben and propylparaben's effect on zebrafish during early embryonic stages. Besides this, the association between alteration in anxiety-like neurobehavioral response with oxidative stress and antioxidant status in head region was also studied. The study results showed variation in the toxic signature left by butylparaben and propylparaben on developmental parameters such as hatching rate, survival and non-lethal malformations in a time-dependent manner. Data from the light-dark preference test showed embryonic exposure to butylparaben and propylparaben to trigger anxiety-like behavior in zebrafish larvae. In addition, a significant increase in intracellular ROS and LP levels correlated with suppressed antioxidant enzymes: superoxide dismutases (SOD), catalases (CAT), Glutathione peroxidase (GPx), glutathione S-transferase (GST), and Glutathione (GSH) activity in the head region of the zebrafish larvae. Acetylcholinesterase (AChE) activity was also suppressed in the exposed groups, along with increased nitric oxide production. The overall observations show increased oxidative stress indices correlating with upregulated expression of apoptotic cells in a dose-dependent manner. Collectively, our findings reveal butylparaben and propylparaben as an anxiogenic neuroactive Christy Lite, Ajay Guru, and Melita Juliet contributed equally to this study.

show abstract

Exposure to benzophenones, parabens and triclosan among pregnant women in different trimesters

Cited by 35 publications

References 50 publications

The association of prenatal exposure to benzophenones with gestational age and offspring size at birth

The association of prenatal exposure to benzophenones with gestational age and offspring size at birth

Urinary concentrations of phthalate metabolites, bisphenols and personal care product chemical biomarkers in pregnant women in Israel

Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae

Contact Info

Product

Resources

About