Expression and clinical implications of P53, P63, and P73 protein in malignant tumor of the parotid gland

Mei, Yong; Yang, Lijun; Suyila, Qimuge; Han, Wenyan; Yuan, Hong-Wen; Zhao, Cheng; Su, Xiulan

doi:10.3906/sag-1304-136

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…Similarly, Liu et al [8] also reported that TP73 was overexpressed in cervical cancer tissues compared with normal cervical tissues. In addition, high expression of TP73 was suggested in several kinds of human tumors such as breast cancer [15,16], esophageal cancer [17], thymic carcinoma [18], extrahepatic bile duct carcinoma [19], cholangiocellular carcinoma [20], hepatocellular carcinoma [21,22], gastric cancer [23,24], colorectal cancer [25–27], ovarian cancer [28], laryngeal cancer [29], parotid gland carcinoma [30], cutaneous melanoma [31] and retinoblastoma [32]. However, low TP73 expression was observed in bladder cancer and head and neck squamous cell carcinoma, compared to corresponding normal tissues [33,34].…”

Section: Discussionmentioning

confidence: 99%

TP73 is a credible biomarker for predicting clinical progression and prognosis in cervical cancer patients

Guo²

2019

Bioscience Reports

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Tumor protein p73 (TP73) has been reported to be dysregulated in various types of human cancer and associated with clinical progression and outcome. Owing to the lack of reports on the correlation between TP73 protein expression and clinicopathologic features of cervical cancer, the aim of our research was to explore the clinical and prognostic significance of TP73 protein expression in cervical cancer patients. In our study, TP73 protein expression was detected by immunochemistry in 118 paraffin-embedded cervical cancer tissue specimens and 40 paraffin-embedded normal cervical epithelium tissue specimens. In the results, we found cervical cancer tissues exhibited high TP73 expression in comparison with normal cervical epithelium tissues, which was consistent with the expression status of TP73 in The Cancer Genome Atlas (TCGA) database. Furthermore, we analyzed the relationships between TP73 expression and clinicopathologic features through using the chi-square test or Fisher’s exact test, and found high expression of TP73 was markedly associated with early clinical stage, less lymph node metastasis, absent distant metastasis, squamous cell carcinoma and favorable histological grade. The Kaplan–Meier method and log-rank test were performed based on the expression level of TP73 in a cervical cancer cohort from the TCGA database, and showed that TP73 expression was positively correlated with overall survival time in cervical cancer patients. Moreover, univariate and multivariate Cox proportional hazards regression model indicated that high TP73 expression was identified as an independent factor for predicting favorable overall survival in cervical cancer patients. In conclusion, TP73 expression is increased in cervical cancer tissues and cells, and acts as a credible biomarker for predicting favorable overall survival in cervical cancer patients.

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Section: Discussionmentioning

confidence: 99%

TP73 is a credible biomarker for predicting clinical progression and prognosis in cervical cancer patients

Guo²

2019

Bioscience Reports

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“…In the present study, the study and control groups were not obviously different in the clinical general data, according to the comparison between the two groups (P>0.05), protecting this experiment from the interference by some basic clinical indicators. The analysis of the relationship between the expression level of p73 in the peripheral blood and the clinicopathological features of WT revealed the differences of the p73 expression levels among patients with different tumor sizes, pathological types, lymph node metastasis, and treatment outcomes (P<0.05), suggesting the important role of p73 in the occurrence and development of WT (28). This study found that the expression level of p73 in the peripheral blood of the study group (4.04±0.79) was much higher than that of the control group (1.57±1.12), indicating the high concentration of p73 in the patients serum.…”

Section: Discussionmentioning

confidence: 99%

Expression and clinical significance of p73 in Wilms' tumor in children

Ding

Liu

et al. 2019

Oncol Lett

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Expression and clinical significance of p73 in children with Wilms tumor (WT) were investigated. A retrospective analysis was carried out on 50 children diagnosed with WT in the People's Hospital of Rizhao, from July 2013 to January 2015 (study group), and 20 healthy children with similar age and sex who received health examinations in the same hospital during the same period (control group). The relative expression of p73 mRNA in the peripheral blood of each group was detected by reverse transcription-quantitative PCR (RT-qPCR) in order to study the association between p73 and the clinicopathological parameters of WT, as well as the impact of p73 on the patient prognosis. The two groups were not statistically different in respect to the clinical data of patients (P>0.05); the expression level of p73 in the blood samples of the study group was significantly higher than that of the control group (t=11.44, P<0.01); the expression of p73 in the study group was associated with factors, including tumor size, pathological type and lymphatic metastasis. Considering the mean value of the expression of p73 (3.32) as the boundary, the patients with expression value of p73 <3.32 were studied as the low-expression group, and patients with expression value of p73 >3.32 comprised the high-expression group. At the end of the follow-up, the median survival time and the survival rate of the patients in the high-expression group were significantly lower than those of the low-expression group (P<0.05). The high expression of p73 in the peripheral blood of children with WT was positively correlated with the clinical stage of the tumor, and was closely related with the low survival rate of patients.

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“…Each section was observed in 10 random fields under ×200 magnification (18). The score was calculated by adding the scores for intensity (weak=1, moderate=2, intense=3) and proportion (5%=1, 6–24%=2, 25–49%=3, 50–74%=4, ≥75%=5) of positively stained cells (19). Scores of ≥2 were considered positive.…”

Section: Methodsmentioning

confidence: 99%

Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma

Chang

et al. 2016

Oncology Letters

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The etiology of laryngeal squamous cell carcinoma (LSCC) has not yet been adequately examined. Therefore, the present study aimed to investigate the association between serum folate deficiency and abnormal expression of the cell adhesion molecule 1 (CADM1) protein in the progression of LSCC. Samples were collected from 60 patients with LSCC and 30 healthy people. Radioimmunoassays and immunohistochemical staining were performed to measure serum folate levels and CADM1 protein expression, respectively. The results demonstrated that CADM1 expression in LSCC specimens was significantly lower than in adjacent normal tissues (χ2=28.229, P<0.001), which was associated with histological differentiation and clinical stage (P=0.010 and 0.020, respectively). Levels of serum folate in patients with LSCC were significantly lower than those observed in healthy individuals (P=0.002). Furthermore, TSLCl expression and serum folate levels were positively correlated in LSCC (r=0.642, P=0.001). Thus, the present study determined that decreased CADM1 protein expression and low levels of serum folate were correlated with an increased severity of LSCC.

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Expression and clinical implications of P53, P63, and P73 protein in malignant tumor of the parotid gland

Cited by 6 publications

References 19 publications

TP73 is a credible biomarker for predicting clinical progression and prognosis in cervical cancer patients

TP73 is a credible biomarker for predicting clinical progression and prognosis in cervical cancer patients

Expression and clinical significance of p73 in Wilms' tumor in children

Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma

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