Expression and function of miRNA in postoperative radiotherapy sensitive and resistant patients of non-small cell lung cancer

miRNAs as Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer: Current Perspectives

“…Wang et al [110] found 12 differently expressed miRNAs in radiotherapy-sensitive and radiotherapy-resistant NSCLC samples (n = 30). When comparing with resistant patients, five miRNAs (miR-126, miR-let-7a, miR-495, miR-451 and miR128b) were significantly upregulated and seven miRNAs (miR-130a, miR-106b, miR-19b, miR-22, miR-15b, miR-17-5p and miR-21) were downregulated in the radiotherapysensitive group.…”

MicroRNAs and Their Impact on Radiotherapy for Cancer

“…For example, using samples from patients with non-small cell lung cancer, Wang et al demonstrated that 5 miRNAs were significantly upregulated in radiosensitive tumors (let7a; miR-126, -128b, -451, -495) and 7 miRNAs were downregulated compared to controls (miR-15b; -17-5p, -19b, -21, -22, -106b, -130a) (22). In another study, higher miR18a expression levels were observed in tumors from patients who failed to respond to radiation treatment, compared to responders (P ¼ 0.019) (23).…”

“…Overexpression of miR-125b results in decreased ICAM-2 levels and proliferation rates (66). Induction of apoptosis, possibly mediated by inactivation of the PI3K-Akt pathway, can also be a result of miR-126 overexpression, and lead to enhanced radiosensitivity (22). In an irradiated non-Hodgkin's lymphoma cell line, miR-148b has been found to increase radiosensitivity of cells (67).…”

Different micro-RNA expression profiles distinguish subtypes of neuroendocrine tumors of the lung: results of a profiling study

“…2,43 miR-126 may promote lung cancer cells irradiation-induced apoptosis through the PI3K-AKT pathway. 2,44 However, data on the role of miRNA expression in neuroendocrine tumors of the lung are limited, and the function of several miRNAs, which are well-documented cancer-related miRNAs in other cancer types, has not been investigated in neuroendocrine lung tumors so far. 3,5 Furthermore, we hypothesized that specific 'biomarker miRNAs' might exist that could distinguish more accurately and reliably between subtypes of pulmonary neuroendocrine tumors.…”