Expression and mechanism of action of miR-196a in epithelial ovarian cancer

Abstract

The miR-196a might serve as a cancer-promoting gene to promote the migration and invasion of epithelial ovarian cancer by downstream target gene HOXA10.

MicroRNA-196a promotes cell proliferation and inhibits apoptosis in human ovarian cancer by directly targeting DDX3 and regulating the PTEN/PI3K/AKT signaling pathway

“…mir-196a is highly expressed in ovarian cancer and is associated with various other types of cancer; therefore, it could represent an important biomarker for cancer diagnosis and prognosis (12,13). in epithelial ovarian cancer progression, Yang et al (14) found that mir-196a promoted ovarian cancer cell migration and invasion through the downstream target gene HoXa10; however, these authors did not report the regulatory mechanisms of mir-196a and HoXa10. notably, there are few studies on the precise regulatory mechanisms of mir-196a in ovarian cancer progression.…”

“…Furthermore, high levels of mir-196a expression have been found to be related to poor survival in patients with ovarian cancer; thus, it is a potential biomarker for the clinical prognosis of ovarian carcinoma (12,13). a preliminarily evaluation of the regulatory mechanisms of mir-196a in ovarian cancer suggested that mir-196a may act as an oncogene to promote migration and invasion through the downstream target gene homeobox A10 (HOXA10) (14). Despite these findings, the regulatory mechanisms of mir-196a in ovarian cancer are yet to be fully elucidated.…”

Identification of miR-146a and miR-196a-2 single nucleotide polymorphisms at patients with high-grade serous ovarian cancer

“…The protein product of that is a nonhistone protein (high mobility AT-hook 2), and its function is permissive in those effects (some types of radiation, chemotherapy) causing double-stranded DNA fractures. Earlier studies analyzed the expression of miR-196-a in ovarian cancer cell lines [26]. Based on their results miR-196a was identified as a tumor promoter with the target HOXA 10 gene in downstream localization.…”

miR-196a Is Able to Restore the Aggressive Phenotype of Annexin A1 Knock-Out in Pancreatic Cancer Cells by CRISPR/Cas9 Genome Editing

“…Despite that miR-196a is not the more dysregulated miRNAs among the listed ones, we selected this sequence since it has been found playing a critical role in the pathogenesis of several cancer models [ 53 , 54 , 55 , 56 , 57 ], including the pancreatic one. Interestingly, in this system, it can be used as the discriminating factor of cancer lesions from normal tissues and chronic pancreatitis [ 26 , 27 , 28 ].…”