2022
DOI: 10.3389/fendo.2022.1067529
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Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders

Abstract: The development of autism spectrum disorders (ASDs) involves both environmental factors such as maternal diabetes and genetic factors such as neuroligins (NLGNs). NLGN2 and NLGN3 are two members of NLGNs with distinct distributions and functions in synapse development and plasticity. The relationship between maternal diabetes and NLGNs, and the distinct working mechanisms of different NLGNs currently remain unclear. Here, we first analyzed the expression levels of NLGN2 and NLGN3 in a streptozotocin-induced AS… Show more

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Cited by 5 publications
(2 citation statements)
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“…This is consistent with the findings of our gene GO analysis. Besides, abnormalities of key genes in the cell junction assembly pathway can cause the development of ASD ( Zhang et al., 2022 ). Through the action of bile acids and SCFAs, gut microbiota can also alter the energy metabolism of intestinal epithelial mitochondria, activate immune system cells, and modulate intestinal epithelial barrier function ( Dunislawska et al., 2023 ).…”
Section: Discussionmentioning
confidence: 99%
“…This is consistent with the findings of our gene GO analysis. Besides, abnormalities of key genes in the cell junction assembly pathway can cause the development of ASD ( Zhang et al., 2022 ). Through the action of bile acids and SCFAs, gut microbiota can also alter the energy metabolism of intestinal epithelial mitochondria, activate immune system cells, and modulate intestinal epithelial barrier function ( Dunislawska et al., 2023 ).…”
Section: Discussionmentioning
confidence: 99%
“…Neuroligin, a postsynaptic cell-adhesion molecule, interacts with presynaptic and intracellular partners, such as neurexins and postsynaptic scaffolding proteins, to facilitate synaptic maturation and transmission ( Krueger et al, 2012 ). Patients with ASD have been found to carry mutations in neuroligin-3 ( Nlgn3 ), resulting in an arginine-to-cysteine substitution at the 451st amino acid residue (R451C; Jamain et al, 2003 ; Hosie et al, 2019 ; Zhang et al, 2022 ). GI-related problems, such as diarrhea and chronic gut pain, have also been confirmed in patients with the NL3 R451C genetic mutation ( Hosie et al, 2019 ).…”
Section: Genetic Risk Factors Relevance To Gi Comorbidities In Asdmentioning
confidence: 99%