Expression of Adhesion Molecules and Cyclin D1 in Cells of Solid-Pseudopapillary Tumors of the Pancreas

Дубова, Е. А.; Podgornova, M. N.; Schegolev, Aleksandr

doi:10.1007/s10517-010-0849-8

Cited by 5 publications

(10 citation statements)

References 9 publications

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“…However, malignancy in SPNs does not correlate with tumor size [22]. Mean tumor size has ranged from 4.7 to 9.5 cm in various studies [5,8,9,12,14,16,18,23]. Tumor size in our resection specimens ranged from 3 to 14 cm with mean size of 9.5 cm.…”

Section: Introductionmentioning

confidence: 64%

“…Of the 19 resection specimens in our series, cut surface in most cases showed areas of hemorrhage, infarction, necrosis, cystic degeneration and cavitation (spongy appearance). In Dubova et al's series, hemorrhagic foci and bloodfilled cavities were seen in 40% cases [9]. Direct splenic invasion can occur in pancreatic tail SPNs [24].…”

Section: Discussionmentioning

confidence: 89%

“…SPNs are rare tumors comprising only 1 to 3% of all pancreatic tumors and show a marked female preponderance and excellent prognosis [5]. Various studies have reported mean age at diagnosis ranging from 24 to 39 years and age range of 7 to 83 years [6][7][8][9][10][11][12][13][14][15][16][17][18]. Cases in children, older patients and males have also been reported [19].…”

Section: Introductionmentioning

confidence: 99%

“…Owing to their often-silent nature, they may be quite bulky when first discovered [1,20]. SPNs do not show preference for any specific part of the pancreas [9]. In Wang et al's series, 38.1% cases were located in the head of pancreas while 49.5% were localized to the body and tail [8].…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and immunohistochemical study of 29 cases of solid-pseudopapillary neoplasms of the pancreas in patients under 20 years of age along with detailed review of literature

et al. 2020

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Background Pancreatic Solid Pseudopapillary Neoplasms (SPNs) are rare low-grade malignant tumors with a marked preponderance for young females. Objective was to describe the morphology, differential diagnosis, and prognosis of SPNs in patients under 20 years of age and present a detailed review of literature. Methods A total of 29 cases in patients under 20 years of age reported as SPN during the period January 2014 to December 2019, were included in the study. These included 19 resection specimens, 4 incision biopsies and 6 cases received as blocks for second opinion. Hematoxylin and eosin (H&E) slides as well as immunohistochemistry (IHC) slides of all cases were retrieved and reviewed by the authors. TFE3 and Progesterone Receptor were performed retrospectively. Results Twenty-eight of the 29 patients were females. Ages of patients ranged from 12 to 19 years. Nineteen cases were resections. Tail was the commonest location. Mean tumor size was 9.5 cm. In 89.5% cases, tumor was confined to the pancreas. In 2 cases, distant metastasis was present. In 2 cases, extension beyond pancreas was seen. Solid and pseudopapillary areas were seen in all cases while other features were variable. Beta catenin and Cyclin D1 were positive in most cases while TFE3 was positive in 57% cases. Progesterone Receptor (PR) was positive in all 13 cases in which it was performed. Follow up was available in 14 patients. Follow up period ranged from 3 to 70 months. Twelve were alive and well without recurrence or metastasis while 2 were alive with recurrence and metastasis to liver and omentum respectively. Conclusions Although many studies on SPNs have been published, surgeons, oncologists and even pathologists in this part of the world are often not aware of these rare tumors leading to inaccuracies and delays in diagnosis. In addition, this paper focusses on the interesting observation that the majority of SPNs diagnosed in our department during study period occurred in patients under 20 years of age (29 versus 21 in patients over 20). However, clinico-epidemiological, morphologic and prognostic features were similar in both age groups. Possibility of SPNs should always be considered in case of pancreatic neoplasms occurring in patients under 20 years of age as well. We believe that this is a very interesting and helpful study for the clinicians as well as the pathologists.

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Section: Introductionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and immunohistochemical study of 29 cases of solid-pseudopapillary neoplasms of the pancreas in patients under 20 years of age along with detailed review of literature

et al. 2020

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“…Cyclin D1, encoded by the CCND1 gene, is the first cyclin synthesized in G1 phase and function as an initiation factor in the cell cycle. CCND1 is regarded as an oncogene which accelerates G1/S transition, leading to uncontrolled cell proliferation and tumor progression 30 . High CCND1 expression is of great significance in tumors.…”

Section: Discussionmentioning

confidence: 99%

MiR‐129‐5p induces cell cycle arrest through modulating HOXC10/Cyclin D1 to inhibit gastric cancer progression

Lin

et al. 2020

FASEB j.

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MicroRNAs (miRNAs) play important roles in posttranscriptional regulation and may serve as targets for the diagnosis and treatment of cancers. Nevertheless, a comprehensive understanding of miRNAs profiles in gastric cancer progression is still lacking. Here, we report that miR‐129‐5p is downregulated in gastric cancer by analyzing TCGA database (n = 41) and clinical tumor samples (n = 60). MiR‐129‐5p transfection suppressed gastric cancer cell proliferation through inducing G1 phase arrest in vitro and inhibit xenograft tumor growth in vivo. MiR‐129‐5p directly targeted the 3′ untranslated regions (3′ UTR) of HOXC10 mRNA and downregulated its expression. Importantly, miR‐129‐5p could reverse the oncogenic effect induced by HOXC10. We systemically screened the downstream target of HOXC10 by ChIP sequencing, and found that HOXC10 could transcriptionally regulate the expression of Cyclin D1 and facilitate G1/S cell cycle transition. Notably, high levels of HOXC10 and Cyclin D1 were related with poor prognosis of gastric cancer patients (n = 90). These findings reveal a novel role of miR‐129‐5p/HOXC10/Cyclin D1 axis in modulating cell cycle and gastric tumorigenesis, which might provide potential prognostic biomarkers and therapeutic targets for gastric cancer patients.

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Vascular Malformations and Their Treatment in the Growing Patient

Kolokythas

2016

Oral and Maxillofacial Surgery Clinics of North America

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Expression of Adhesion Molecules and Cyclin D1 in Cells of Solid-Pseudopapillary Tumors of the Pancreas

Cited by 5 publications

References 9 publications

Clinicopathological and immunohistochemical study of 29 cases of solid-pseudopapillary neoplasms of the pancreas in patients under 20 years of age along with detailed review of literature

Clinicopathological and immunohistochemical study of 29 cases of solid-pseudopapillary neoplasms of the pancreas in patients under 20 years of age along with detailed review of literature

MiR‐129‐5p induces cell cycle arrest through modulating HOXC10/Cyclin D1 to inhibit gastric cancer progression

Vascular Malformations and Their Treatment in the Growing Patient

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