Expression of alpha 1 and beta 3 integrins subunits in the endometrium of patients with tubal phimosis or hydrosalpinx

Savaris, Ricardo Francalacci; Pedrini, José Luiz; Flores, Renato Bueno; Fabris, Gemir; Zettler, Cláudio Galleano

doi:10.1016/j.fertnstert.2005.06.039

Cited by 31 publications

(21 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Correctable causes of implantation failure have been identified that are associated with endometrial integrin deficiency, such as communicating hydrosalpinges (Meyer et al, 1997;Bildirici et al, 2001;Savaris et al, 2006) and endometriosis (Lessey et al, 1994a,b). In cases of unexplained IVF failure, low integrin expression has been described (Tei et al, 2003), while positive integrin expression is predictive of future IVF success (Thomas et al, 2003a, b).…”

Section: Introductionmentioning

confidence: 99%

Endometrial receptivity defects during IVF cycles with and without letrozole

et al. 2012

View full text Add to dashboard Cite

background: Our aim was to study ways to improve IVF success rates in women with suspected endometrial receptivity defects. methods: We conducted a retrospective cohort study examining the effect of letrozole (aromatase inhibitor) on integrin expression as a marker of endometrial receptivity. We compared IVF outcomes in 97 infertile women who had undergone anb3 integrin assessment by immunohistochemistry in mid-luteal endometrial biopsies. Of 79 women undergoing standard IVF, 29 (36.7%) lacked normal integrin expression. Eighteen other women with low integrin were studied after receiving letrozole during early IVF stimulation. An independent set of anb3 integrin-negative patients (n ¼ 15) who had undergone repeat endometrial biopsy for integrin testing while taking letrozole were re-evaluated.results: Clinical pregnancy and delivery rates were higher in women with normal anb3 integrin expression compared with those who were integrin negative [20/50 (40%) versus 4/29 (13.8%); P ¼ 0.02 and 19/50 (38%) versus 2/29 (7%); P , 0.01, respectively]. In 18 women who received letrozole early in IVF, 11 conceived (61.1%; P , 0.001) compared with integrin-negative patients who did not receive letrozole. In integrin-negative women who were rebiopsied on letrozole, 66.7% reverted to normal integrin expression. Positive endometrial aromatase immunostaining using a polyclonal antibody was a common finding in infertile patients compared with controls.conclusions: Lack of endometrial anb3 integrin expression is associated with a poor prognosis for IVF that might be improved with letrozole co-treatment. Prospective studies are needed to confirm and extend these findings but the data suggest that aromatase expression may contribute to implantation failure in some women.

show abstract

Section: Introductionmentioning

confidence: 99%

Endometrial receptivity defects during IVF cycles with and without letrozole

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Although the perfect protein marker would be functionally important to the process of implantation, consensus as to which biomarkers to use for endometrial receptivity has not been established. As recently reviewed (34), receptivity defects have been noted in a variety of clinical disorders, including tubal disease (50)(51)(52), endometriosis (53)(54)(55), and polycystic ovary syndrome (56)(57)(58)(59). With the number of potential candidates generated through molecular techniques growing steadily (7,38,40,41,60), the focus on one over another biomarker has become increasingly problematic.…”

mentioning

confidence: 99%

Assessment of endometrial receptivity

Lessey

2011

Fertility and Sterility

217

122

View full text Add to dashboard Cite

“…The hydrosalpinx fluid may contain microorganisms, endotoxins, cytokines, debris, and/or prostaglandins that can exert a direct adverse effect on the developing embryos and reduce endometrial receptivity by diminishing the expression of molecules such as HOXA10, b3 integrin, and vascular endothelial growth factor, consequently resulting in poor vascular development and decrease in endometrial blood flow (19)(20)(21). Little attention has been paid to the blood perfusion of the uterine helicine artery in women with hydrosalpinx, and published data in this field are very limited.…”

mentioning

confidence: 99%